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    Wars2 tryptophanyl tRNA synthetase 2 (mitochondrial) [ Mus musculus (house mouse) ]

    Gene ID: 70560, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wars2provided by MGI
    Official Full Name
    tryptophanyl tRNA synthetase 2 (mitochondrial)provided by MGI
    Primary source
    MGI:MGI:1917810
    See related
    Ensembl:ENSMUSG00000004233 AllianceGenome:MGI:1917810
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TrpRS; 5730427B17Rik; 9430020O07Rik
    Summary
    Predicted to enable tryptophan-tRNA ligase activity. Acts upstream of or within vasculogenesis. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; ear; genitourinary system; and skeleton. Orthologous to human WARS2 (tryptophanyl tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 1.9), CNS E11.5 (RPKM 1.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Wars2 in Genome Data Viewer
    Location:
    3 F2.2; 3 43.03 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (99047423..99128546)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (99140107..99221230)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40105 Neighboring gene predicted gene, 22341 Neighboring gene predicted gene, 24216 Neighboring gene STARR-positive B cell enhancer ABC_E2089 Neighboring gene STARR-seq mESC enhancer starr_08484 Neighboring gene S-adenosylmethionine decarboxylase, pseudogene 3 pseudogene Neighboring gene microRNA 6481 Neighboring gene predicted gene, 38468 Neighboring gene predicted gene, 46817 Neighboring gene T-box 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A Wars2 mutant mouse shows a sex and diet specific change in fat distribution, reduced food intake and depot-specific upregulation of WAT browning. Mušo M, et al. Front Physiol, 2022. PMID 36091365, Free PMC Article
    2. A Wars2 Mutant Mouse Model Displays OXPHOS Deficiencies and Activation of Tissue-Specific Stress Response Pathways. Agnew T, et al. Cell Rep, 2018 Dec 18. PMID 30566859, Free PMC Article
    3. T2-TrpRS inhibits preretinal neovascularization and enhances physiological vascular regrowth in OIR as assessed by a new method of quantification. Banin E, et al. Invest Ophthalmol Vis Sci, 2006 May. PMID 16639024
    4. Species-specific differences in the regulation of the aminoacylation activity of mammalian tryptophanyl-tRNA synthetases. Wakasugi K. FEBS Lett, 2010 Jan 4. PMID 19941862
    5. Novel gene function revealed by mouse mutagenesis screens for models of age-related disease. Potter PK, et al. Nat Commun, 2016 Aug 18. PMID 27534441, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tryptophan-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tryptophan-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tryptophan-tRNA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial tryptophanyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tryptophanyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vasculogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tryptophan--tRNA ligase, mitochondrial
    Names
    (Mt)TrpRS
    tryptophanyl-tRNA synthetase, mitochondrial
    NP_001405926.1
    NP_081738.2
    XP_006502116.1
    XP_017175206.1
    XP_030108675.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418997.1 → NP_001405926.1  tryptophan--tRNA ligase, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC080018

    2. NM_027462.5 → NP_081738.2  tryptophan--tRNA ligase, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_081738.2

      Status: VALIDATED

      Source sequence(s)
      AC080018
      Consensus CDS
      CCDS17672.1
      UniProtKB/Swiss-Prot
      Q8BFV8, Q9CYK1
      Related
      ENSMUSP00000004343.3, ENSMUST00000004343.7
      Conserved Domains (2) summary
      cd00806
      Location:36 → 312
      TrpRS_core; catalytic core domain of tryptophanyl-tRNA synthetase
      PRK00927
      Location:35 → 360
      PRK00927; tryptophanyl-tRNA synthetase; Reviewed

    RNA

    1. NR_185000.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC080018

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      99047423..99128546
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502053.5 → XP_006502116.1  tryptophan--tRNA ligase, mitochondrial isoform X4

      UniProtKB/TrEMBL
      A0A0G2JDR5
      Conserved Domains (1) summary
      PRK00927
      Location:58 → 195
      PRK00927; tryptophanyl-tRNA synthetase; Reviewed

    2. XM_017319717.3 → XP_017175206.1  tryptophan--tRNA ligase, mitochondrial isoform X1

      Conserved Domains (1) summary
      PRK00927
      Location:58 → 235
      PRK00927; tryptophanyl-tRNA synthetase; Reviewed

    3. XM_030252815.1 → XP_030108675.1  tryptophan--tRNA ligase, mitochondrial isoform X3

      Conserved Domains (1) summary
      PRK00927
      Location:1 → 231
      PRK00927; tryptophanyl-tRNA synthetase; Reviewed

    RNA

    1. XR_001783742.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CYK1.2 GenPept UniProtKB/Swiss-Prot:Q9CYK1

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