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    Socs4 suppressor of cytokine signaling 4 [ Mus musculus (house mouse) ]

    Gene ID: 67296, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Socs4provided by MGI
    Official Full Name
    suppressor of cytokine signaling 4provided by MGI
    Primary source
    MGI:MGI:1914546
    See related
    Ensembl:ENSMUSG00000048379 AllianceGenome:MGI:1914546
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Socs7; 3110032M18Rik; A730004F22Rik
    Summary
    Predicted to be involved in cytokine-mediated signaling pathway; negative regulation of epidermal growth factor-activated receptor activity; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Is expressed in ganglia; sensory organ; thymus primordium; and ventricular layer. Orthologous to human SOCS4 (suppressor of cytokine signaling 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 5.2), CNS E11.5 (RPKM 4.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Socs4 in Genome Data Viewer
    Location:
    14 C1; 14 24.6 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (47514377..47533559)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (47276920..47296102)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene GTP cyclohydrolase 1 Neighboring gene poly(A) binding protein, cytoplasmic 2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:47842732-47842946 Neighboring gene STARR-seq mESC enhancer starr_36567 Neighboring gene WD repeat and HMG-box DNA binding protein 1 Neighboring gene predicted gene, 24378 Neighboring gene STARR-seq mESC enhancer starr_36570 Neighboring gene mitogen-activated protein kinase 1 interacting protein 1-like Neighboring gene predicted gene, 35078 Neighboring gene STARR-seq mESC enhancer starr_36571 Neighboring gene STARR-seq mESC enhancer starr_36572 Neighboring gene predicted gene, 41147

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. In Semliki Forest virus encephalitis, suppressor of cytokine signaling 4 (SOCS4) is an essential modulator of immune responses that mediates the balance between immunopathology and virus clearance. Kedzierski L, et al. Immunol Cell Biol, 2023 Apr. PMID 36702633
    2. Suppressor of cytokine signaling 4 (SOCS4): moderator of ovarian primordial follicle activation. Sutherland JM, et al. J Cell Physiol, 2012 Mar. PMID 21604262
    3. SOCS4 is dispensable for an efficient recall response to influenza despite being required for primary immunity. Kedzierski L, et al. Immunol Cell Biol, 2015 Nov. PMID 26077508
    4. Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection. Kedzierski L, et al. PLoS Pathog, 2014 May. PMID 24809749, Free PMC Article
    5. Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling. Kedzierski L, et al. Elife, 2017 Feb 14. PMID 28195529, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In Semliki Forest virus encephalitis, suppressor of cytokine signaling 4 (SOCS4) is an essential modulator of immune responses that mediates the balance between immunopathology and virus clearance.
      Title: In Semliki Forest virus encephalitis, suppressor of cytokine signaling 4 (SOCS4) is an essential modulator of immune responses that mediates the balance between immunopathology and virus clearance.
    2. dispensable for immunological memory response to influenza virus infection
      Title: SOCS4 is dispensable for an efficient recall response to influenza despite being required for primary immunity.
    3. SOCS4 is a critical regulator of anti-viral immunity.
      Title: Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection.
    4. Identified is a conserved region of about 70 residues in the N-terminal domains of Socs4 and 5 that is predicted to be more ordered than the surrounding sequence.
      Title: The N-terminal domains of SOCS proteins: a conserved region in the disordered N-termini of SOCS4 and 5.
    5. Negative regulation of the JAK/STAT pathway is controlled by SOCS4, which target members of negative feedback loops, to suppress follicle growth and development.
      Title: Suppressor of cytokine signaling 4 (SOCS4): moderator of ovarian primordial follicle activation.
    6. Socs4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism.
      Title: ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC143730, MGC143731

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of epidermal growth factor-activated receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of epidermal growth factor-activated receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    suppressor of cytokine signaling 4
    Names
    SOCS-4
    SOCS-7
    suppressor of cytokine signaling 7
    suppressor of cytokine signalling 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080843.3 → NP_543119.2  suppressor of cytokine signaling 4

      See identical proteins and their annotated locations for NP_543119.2

      Status: VALIDATED

      Source sequence(s)
      AC156016, AK014115, AW046781, BG083279, CJ121925
      Consensus CDS
      CCDS26985.1
      UniProtKB/Swiss-Prot
      Q149F7, Q149F8, Q91ZA6
      Related
      ENSMUSP00000066031.5, ENSMUST00000065562.6
      Conserved Domains (3) summary
      cd10385
      Location:272 → 372
      SH2_SOCS4; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03738
      Location:381 → 436
      SOCS_SOCS4; SOCS (suppressors of cytokine signaling) box of SOCS4-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...
      pfam12610
      Location:58 → 106
      SOCS; Suppressor of cytokine signalling

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      47514377..47533559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91ZA6.2 GenPept UniProtKB/Swiss-Prot:Q91ZA6

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