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    Zkscan14 zinc finger with KRAB and SCAN domains 14 [ Mus musculus (house mouse) ]

    Gene ID: 67235, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zkscan14provided by MGI
    Official Full Name
    zinc finger with KRAB and SCAN domains 14provided by MGI
    Primary source
    MGI:MGI:1914485
    See related
    Ensembl:ENSMUSG00000029627 AllianceGenome:MGI:1914485
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp99; Znf394; 2310046C23Rik; 2810437E14Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in central nervous system; early conceptus; and genitourinary system. Orthologous to human ZNF394 (zinc finger protein 394). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 2.2), cerebellum adult (RPKM 2.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zkscan14 in Genome Data Viewer
    Location:
    5 G2; 5 85.12 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (145131756..145140972, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (145194946..145204164, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6397 Neighboring gene cleavage and polyadenylation specific factor 4 Neighboring gene ATP synthase membrane subunit f Neighboring gene STARR-positive B cell enhancer ABC_E1316 Neighboring gene STARR-positive B cell enhancer ABC_E533 Neighboring gene zinc finger with KRAB and SCAN domains 5 Neighboring gene STARR-positive B cell enhancer ABC_E4805 Neighboring gene zinc finger protein 655

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ZNF384 Fusion Oncoproteins Drive Lineage Aberrancy in Acute Leukemia. Dickerson KM, et al. Blood Cancer Discov, 2022 May 5. PMID 35247902, Free PMC Article
    2. Three novel spermatogenesis-specific zinc finger genes. Weissig H, et al. FEBS Lett, 2003 Jul 17. PMID 12860387
    3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    4. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article
    5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF384 Fusion Oncoproteins Drive Lineage Aberrancy in Acute Leukemia.
      Title: ZNF384 Fusion Oncoproteins Drive Lineage Aberrancy in Acute Leukemia.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117641

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 394
    Names
    zfp-94
    zinc finger protein 94
    zinc finger protein 99
    zinc finger protein with KRAB and SCAN domains 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023322.2 → NP_075811.2  zinc finger protein 394

      See identical proteins and their annotated locations for NP_075811.2

      Status: VALIDATED

      Source sequence(s)
      AI195146, AK013258, CJ072232
      Consensus CDS
      CCDS19860.1
      UniProtKB/Swiss-Prot
      B9EIZ4, Q3U4Z1, Q9CYV9, Q9CZG8, Q9Z1D9
      Related
      ENSMUSP00000031632.9, ENSMUST00000031632.9
      Conserved Domains (8) summary
      smart00431
      Location:40 → 151
      SCAN; leucine rich region
      cd07765
      Location:135 → 173
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:135 → 193
      KRAB; krueppel associated box
      COG5048
      Location:303 → 484
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:329 → 349
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:438 → 460
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:40 → 128
      SCAN; SCAN domain
      pfam13465
      Location:341 → 366
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      145131756..145140972 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241012.4 → XP_011239314.1  zinc finger protein 394 isoform X1

      Conserved Domains (4) summary
      smart00349
      Location:1 → 59
      KRAB; krueppel associated box
      COG5048
      Location:169 → 350
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:195 → 215
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:347 → 371
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z1D9.3 GenPept UniProtKB/Swiss-Prot:Q9Z1D9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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