Clps colipase, pancreatic [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Clpsprovided by MGI
Official Full Name: colipase, pancreaticprovided by MGI
Primary source: MGI:MGI:88421
See related: Ensembl:ENSMUSG00000024225 AllianceGenome:MGI:88421
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2200003J09Rik
Summary: This gene encodes a member of the colipase family of coenzymes that is required for the optimal activity of pancreatic lipase. The encoded protein undergoes proteolytic processing to generate a mature polypeptide that binds to the lipase and prevents inhibition by bile acids. Over half of the mice lacking the encoded protein die within two weeks of birth while the remaining ones exhibit fat malabsorption and altered body weight regulation. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Nov 2015]
Expression: Restricted expression toward stomach adult (RPKM 112946.0) See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 14.76 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (28777184..28779740, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (28558210..28560766, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that the conditional expression of mPlrp2 and mClps is involved in the hydrolysis of retinyl esters in the mouse liver.
Title: The mPlrp2 and mClps genes are involved in the hydrolysis of retinyl esters in the mouse liver.
colipase (-/-)mice develop diet-induced obesity, as do colipase (+/+) mice, and have normal responses to a two-macronutrient choice diet and to a switch from a high-fat to a low-fat diet
Title: Enterostatin deficiency increases serum cholesterol but does not influence growth and food intake in mice.
We conclude that, in addition to its critical role in fat digestion, procolipase has essential functions in postnatal development and in regulating body weight set point.
Title: Decreased postnatal survival and altered body weight regulation in procolipase-deficient mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (5) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme activator activity	IEA Inferred from Electronic Annotation more info
enables enzyme activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables enzyme activator activity	ISO Inferred from Sequence Orthology more info
enables lipase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in digestion	IEA Inferred from Electronic Annotation more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to food	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinoid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: colipase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001317065.1 → NP_001303994.1 colipase isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1. This isoform (2) may undergo proteolytic processing similar to isoform 1.

Source sequence(s)

AK008815, BM570078, BQ126290

Consensus CDS

CCDS84287.1

UniProtKB/TrEMBL

B2KF29

Related

ENSMUSP00000110433.2, ENSMUST00000114785.3

Conserved Domains (2) summary

smart00023
Location:19 → 72

COLIPASE; Colipase

cl24053
Location:30 → 67

COLIPASE; Colipase; a stoichiometric cofactor for pancreatic lipase, allowing the enzyme to anchor itself to the water-lipid interface and stabilizing the active enzyme conformation
NM_025469.3 → NP_079745.1 colipase isoform 1 preproprotein

See identical proteins and their annotated locations for NP_079745.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK008815, BM570078, BQ126290

Consensus CDS

CCDS28581.1

UniProtKB/Swiss-Prot

Q8VHR2, Q8VHR3, Q9CQC2

UniProtKB/TrEMBL

Q9D2R7

Related

ENSMUSP00000025062.4, ENSMUST00000025062.5

Conserved Domains (2) summary

cd00039
Location:19 → 108

COLIPASE; Colipase; a stoichiometric cofactor for pancreatic lipase, allowing the enzyme to anchor itself to the water-lipid interface and stabilizing the active enzyme conformation

smart00023
Location:19 → 113

COLIPASE; Colipase