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    Wiz widely-interspaced zinc finger motifs [ Mus musculus (house mouse) ]

    Gene ID: 22404, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wizprovided by MGI
    Official Full Name
    widely-interspaced zinc finger motifsprovided by MGI
    Primary source
    MGI:MGI:1332638
    See related
    Ensembl:ENSMUSG00000024050 AllianceGenome:MGI:1332638
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables SET domain binding activity and histone methyltransferase binding activity. Predicted to be involved in positive regulation of nuclear cell cycle DNA replication; protein stabilization; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; palatal shelf; and retina. Orthologous to human WIZ (WIZ zinc finger). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 12.4), CNS E14 (RPKM 11.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Wiz in Genome Data Viewer
    Location:
    17 B1; 17 17.52 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (32573021..32608463, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (32354047..32389501, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene A kinase anchor protein 8 Neighboring gene STARR-positive B cell enhancer ABC_E5590 Neighboring gene STARR-positive B cell enhancer ABC_E955 Neighboring gene A kinase anchor protein 8-like Neighboring gene STARR-positive B cell enhancer ABC_E1502 Neighboring gene STARR-positive B cell enhancer mm9_chr17:32506256-32506557 Neighboring gene STARR-positive B cell enhancer mm9_chr17:32508595-32508896 Neighboring gene STARR-positive B cell enhancer ABC_E4205 Neighboring gene predicted gene, 53995 Neighboring gene RAS protein activator like 3 Neighboring gene RIKEN cDNA A530088E08 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:32540440-32540643 Neighboring gene predicted gene, 41569 Neighboring gene peptidoglycan recognition protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and distinct developmental expression pattern of spliced forms of a novel zinc finger gene wiz in the mouse cerebellum. Matsumoto K, et al. Brain Res Mol Brain Res, 1998 Oct 30. PMID 9795207
    2. Insertional polymorphisms of ETn retrotransposons include a disruption of the wiz gene in C57BL/6 mice. Baust C, et al. Mamm Genome, 2002 Aug. PMID 12226707
    3. Isolation and characterization of a human gene containing a nuclear localization signal from the critical region for velo-cardio-facial syndrome on 22q11. Funke B, et al. Genomics, 1998 Oct 15. PMID 9790763
    4. Wiz binds active promoters and CTCF-binding sites and is required for normal behaviour in the mouse. Isbel L, et al. Elife, 2016 Jul 13. PMID 27410475, Free PMC Article
    5. Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP. Ueda J, et al. J Biol Chem, 2006 Jul 21. PMID 16702210

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chromatin immunoprecipitation-DNA sequence analysis was performed in adult cerebellum and Wiz peaks were found at promoters and transcription factor CTCF binding sites.
      Title: Wiz binds active promoters and CTCF-binding sites and is required for normal behaviour in the mouse.
    2. Wiz plays a major role in G9a/GLP heterodimer formation in cultured stem cells.
      Title: Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SET domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables histone methyltransferase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables histone methyltransferase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of nuclear cell cycle DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein Wiz
    Names
    widely-interspaced zinc finger-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001372219.1 → NP_001359148.1  protein Wiz isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT033751, CT485616

    2. NM_001372220.1 → NP_001359149.1  protein Wiz isoform 5

      Status: VALIDATED

      Source sequence(s)
      CT033751, CT485616

    3. NM_001372221.1 → NP_001359150.1  protein Wiz isoform 5

      Status: VALIDATED

      Source sequence(s)
      CT033751, CT485616

    4. NM_001372222.1 → NP_001359151.1  protein Wiz isoform 6

      Status: VALIDATED

      Source sequence(s)
      CT033751
      UniProtKB/TrEMBL
      F6ZBR8
      Related
      ENSMUSP00000126253.4, ENSMUST00000169488.10

    5. NM_001372223.1 → NP_001359152.1  protein Wiz isoform 7

      Status: VALIDATED

      Source sequence(s)
      CT033751

    6. NM_001372224.1 → NP_001359153.1  protein Wiz isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT033751, CT485616
      Consensus CDS
      CCDS28617.2
      Related
      ENSMUSP00000069443.8, ENSMUST00000064694.14

    7. NM_001372225.1 → NP_001359154.1  protein Wiz isoform 8

      Status: VALIDATED

      Source sequence(s)
      CT033751

    8. NM_001372226.1 → NP_001359155.1  protein Wiz isoform 9

      Status: VALIDATED

      Source sequence(s)
      CT033751

    9. NM_001372227.1 → NP_001359156.1  protein Wiz isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT033751, CT485616
      UniProtKB/Swiss-Prot
      O88286, O88287, Q1XG03, Q3UZX7, Q7TSJ4, Q9CT89
      UniProtKB/TrEMBL
      A0A494BAG6
      Related
      ENSMUSP00000158082.2, ENSMUST00000236409.2
      Conserved Domains (1) summary
      sd00017
      Location:310 → 330
      ZF_C2H2; C2H2 Zn finger [structural motif]

    10. NM_001410390.1 → NP_001397319.1  protein Wiz isoform 15

      Status: VALIDATED

      Source sequence(s)
      CT033751, CT485616

    11. NM_001410391.1 → NP_001397320.1  protein Wiz isoform 12

      Status: VALIDATED

      Source sequence(s)
      CT033751, CT485616

    12. NM_001410392.1 → NP_001397321.1  protein Wiz isoform 12

      Status: VALIDATED

      Source sequence(s)
      CT033751, CT485616

    13. NM_001410393.1 → NP_001397322.1  protein Wiz isoform 7

      Status: VALIDATED

      Source sequence(s)
      CT033751, CT485616

    14. NM_001410394.1 → NP_001397323.1  protein Wiz isoform 10

      Status: VALIDATED

      Source sequence(s)
      CT033751, CT485616

    15. NM_001410395.1 → NP_001397324.1  protein Wiz isoform 7

      Status: VALIDATED

      Source sequence(s)
      CT033751, CT485616

    16. NM_001410396.1 → NP_001397325.1  protein Wiz isoform 7

      Status: VALIDATED

      Source sequence(s)
      CT033751, CT485616

    17. NM_001410397.1 → NP_001397326.1  protein Wiz isoform 16

      Status: VALIDATED

      Source sequence(s)
      CT033751, CT485616

    18. NM_001410398.1 → NP_001397327.1  protein Wiz isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT033751, CT485616

    19. NM_001410399.1 → NP_001397328.1  protein Wiz isoform 8

      Status: VALIDATED

      Source sequence(s)
      CT033751, CT485616

    20. NM_001410400.1 → NP_001397329.1  protein Wiz isoform 13

      Status: VALIDATED

      Source sequence(s)
      CT033751, CT485616

    21. NM_001410401.1 → NP_001397330.1  protein Wiz isoform 13

      Status: VALIDATED

      Source sequence(s)
      CT033751, CT485616

    22. NM_001410402.1 → NP_001397331.1  protein Wiz isoform 19

      Status: VALIDATED

      Source sequence(s)
      CT033751, CT485616

    23. NM_001410403.1 → NP_001397332.1  protein Wiz isoform 14

      Status: VALIDATED

      Source sequence(s)
      CT033751, CT485616

    24. NM_001410404.1 → NP_001397333.1  protein Wiz isoform 11

      Status: VALIDATED

      Source sequence(s)
      CT033751, CT485616

    25. NM_001410405.1 → NP_001397334.1  protein Wiz isoform 20

      Status: VALIDATED

      Source sequence(s)
      CT033751

    26. NM_001410406.1 → NP_001397335.1  protein Wiz isoform 17

      Status: VALIDATED

      Source sequence(s)
      CT033751

    27. NM_001410407.1 → NP_001397336.1  protein Wiz isoform 11

      Status: VALIDATED

      Source sequence(s)
      CT033751

    28. NM_001410408.1 → NP_001397337.1  protein Wiz isoform 14

      Status: VALIDATED

      Source sequence(s)
      CT033751

    29. NM_001410409.1 → NP_001397338.1  protein Wiz isoform 21

      Status: VALIDATED

      Source sequence(s)
      CT033751

    30. NM_001410410.1 → NP_001397339.1  protein Wiz isoform 18

      Status: VALIDATED

      Source sequence(s)
      CT033751

    31. NM_001423683.1 → NP_001410612.1  protein Wiz isoform 22

      Status: VALIDATED

      Source sequence(s)
      CT033751, CT485616

    32. NM_011717.5 → NP_035847.2  protein Wiz isoform 2

      See identical proteins and their annotated locations for NP_035847.2

      Status: VALIDATED

      Source sequence(s)
      CT033751, CT485616
      Consensus CDS
      CCDS28616.1
      UniProtKB/TrEMBL
      G5E8J8
      Related
      ENSMUSP00000084993.6, ENSMUST00000087703.12

    33. NM_212438.4 → NP_997603.3  protein Wiz isoform 1

      See identical proteins and their annotated locations for NP_997603.3

      Status: VALIDATED

      Source sequence(s)
      CT033751, CT485616
      Consensus CDS
      CCDS28617.2
      UniProtKB/Swiss-Prot
      O88286

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      32573021..32608463 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317402.2 → XP_017172891.1  protein Wiz isoform X18

    2. XM_011246380.2 → XP_011244682.1  protein Wiz isoform X9

      See identical proteins and their annotated locations for XP_011244682.1

    3. XM_036160496.1 → XP_036016389.1  protein Wiz isoform X4

      UniProtKB/Swiss-Prot
      O88286, O88287, Q1XG03, Q3UZX7, Q7TSJ4, Q9CT89
      Conserved Domains (1) summary
      sd00017
      Location:188 → 208
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_036160489.1 → XP_036016382.1  protein Wiz isoform X1

      UniProtKB/Swiss-Prot
      O88286, O88287, Q1XG03, Q3UZX7, Q7TSJ4, Q9CT89
      Conserved Domains (1) summary
      sd00017
      Location:310 → 330
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_006524063.2 → XP_006524126.1  protein Wiz isoform X9

      See identical proteins and their annotated locations for XP_006524126.1

    6. XM_030249670.2 → XP_030105530.1  protein Wiz isoform X19

    7. XM_030249660.2 → XP_030105520.1  protein Wiz isoform X12

    8. XM_006524053.3 → XP_006524116.1  protein Wiz isoform X6

      See identical proteins and their annotated locations for XP_006524116.1

    9. XM_006524057.3 → XP_006524120.1  protein Wiz isoform X7

      See identical proteins and their annotated locations for XP_006524120.1

    10. XM_036160493.1 → XP_036016386.1  protein Wiz isoform X3

      UniProtKB/Swiss-Prot
      O88286, O88287, Q1XG03, Q3UZX7, Q7TSJ4, Q9CT89
      Conserved Domains (1) summary
      sd00017
      Location:310 → 330
      ZF_C2H2; C2H2 Zn finger [structural motif]

    11. XM_036160498.1 → XP_036016391.1  protein Wiz isoform X5

      UniProtKB/Swiss-Prot
      O88286, O88287, Q1XG03, Q3UZX7, Q7TSJ4, Q9CT89
      Conserved Domains (1) summary
      sd00017
      Location:310 → 330
      ZF_C2H2; C2H2 Zn finger [structural motif]

    12. XM_036160492.1 → XP_036016385.1  protein Wiz isoform X2

      UniProtKB/Swiss-Prot
      O88286, O88287, Q1XG03, Q3UZX7, Q7TSJ4, Q9CT89
      Conserved Domains (1) summary
      sd00017
      Location:310 → 330
      ZF_C2H2; C2H2 Zn finger [structural motif]

    13. XM_036160488.1 → XP_036016381.1  protein Wiz isoform X1

      UniProtKB/Swiss-Prot
      O88286, O88287, Q1XG03, Q3UZX7, Q7TSJ4, Q9CT89
      Conserved Domains (1) summary
      sd00017
      Location:310 → 330
      ZF_C2H2; C2H2 Zn finger [structural motif]

    14. XM_006524055.2 → XP_006524118.1  protein Wiz isoform X6

      See identical proteins and their annotated locations for XP_006524118.1

    15. XM_036160491.1 → XP_036016384.1  protein Wiz isoform X1

      UniProtKB/Swiss-Prot
      O88286, O88287, Q1XG03, Q3UZX7, Q7TSJ4, Q9CT89
      Conserved Domains (1) summary
      sd00017
      Location:310 → 330
      ZF_C2H2; C2H2 Zn finger [structural motif]

    16. XM_036160497.1 → XP_036016390.1  protein Wiz isoform X4

      UniProtKB/Swiss-Prot
      O88286, O88287, Q1XG03, Q3UZX7, Q7TSJ4, Q9CT89
      Conserved Domains (1) summary
      sd00017
      Location:188 → 208
      ZF_C2H2; C2H2 Zn finger [structural motif]

    17. XM_030249659.1 → XP_030105519.1  protein Wiz isoform X11

    18. XM_030249657.1 → XP_030105517.1  protein Wiz isoform X11

    19. XM_011246379.1 → XP_011244681.1  protein Wiz isoform X9

      See identical proteins and their annotated locations for XP_011244681.1

    20. XM_036160494.1 → XP_036016387.1  protein Wiz isoform X4

      UniProtKB/Swiss-Prot
      O88286, O88287, Q1XG03, Q3UZX7, Q7TSJ4, Q9CT89
      Conserved Domains (1) summary
      sd00017
      Location:188 → 208
      ZF_C2H2; C2H2 Zn finger [structural motif]

    21. XM_036160500.1 → XP_036016393.1  protein Wiz isoform X11

    22. XM_030249654.1 → XP_030105514.1  protein Wiz isoform X9

    23. XM_036160495.1 → XP_036016388.1  protein Wiz isoform X4

      UniProtKB/Swiss-Prot
      O88286, O88287, Q1XG03, Q3UZX7, Q7TSJ4, Q9CT89
      Conserved Domains (1) summary
      sd00017
      Location:188 → 208
      ZF_C2H2; C2H2 Zn finger [structural motif]

    24. XM_006524062.2 → XP_006524125.1  protein Wiz isoform X8

      See identical proteins and their annotated locations for XP_006524125.1

    25. XM_036160490.1 → XP_036016383.1  protein Wiz isoform X1

      UniProtKB/Swiss-Prot
      O88286, O88287, Q1XG03, Q3UZX7, Q7TSJ4, Q9CT89
      Conserved Domains (1) summary
      sd00017
      Location:310 → 330
      ZF_C2H2; C2H2 Zn finger [structural motif]

    26. XM_006524056.3 → XP_006524119.1  protein Wiz isoform X6

      See identical proteins and their annotated locations for XP_006524119.1

    27. XM_030249655.2 → XP_030105515.2  protein Wiz isoform X4

      UniProtKB/Swiss-Prot
      O88286, O88287, Q1XG03, Q3UZX7, Q7TSJ4, Q9CT89
      Conserved Domains (1) summary
      sd00017
      Location:188 → 208
      ZF_C2H2; C2H2 Zn finger [structural motif]

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_212437.1: Suppressed sequence

      Description
      NM_212437.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88286.2 GenPept UniProtKB/Swiss-Prot:O88286

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