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    Hipk2 homeodomain interacting protein kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 15258, updated on 27-Nov-2024

    Summary

    Official Symbol
    Hipk2provided by MGI
    Official Full Name
    homeodomain interacting protein kinase 2provided by MGI
    Primary source
    MGI:MGI:1314872
    See related
    Ensembl:ENSMUSG00000061436 AllianceGenome:MGI:1314872
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Stank; 1110014O20Rik; B230339E18Rik
    Summary
    Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; protein serine/threonine kinase activity; and transcription corepressor activity. Contributes to transcription coactivator activity. Involved in several processes, including camera-type eye morphogenesis; protein phosphorylation; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including adult walking behavior; cell surface receptor signaling pathway; and intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Located in cytoplasm and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; metanephros; nervous system; paraxial mesenchyme; and sensory organ. Orthologous to human HIPK2 (homeodomain interacting protein kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 22.0), subcutaneous fat pad adult (RPKM 17.3) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Hipk2 in Genome Data Viewer
    Location:
    6 B1; 6 17.85 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (38664447..38853236, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (38687512..38876331, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene killer cell lectin-like receptor subfamily G, member 2 Neighboring gene Clec2l Hedgehog-responsive enhancer Neighboring gene C-type lectin domain family 2, member L Neighboring gene STARR-positive B cell enhancer mm9_chr6:38676623-38676923 Neighboring gene STARR-positive B cell enhancer mm9_chr6:38677325-38677625 Neighboring gene RIKEN cDNA 4930502C15 gene Neighboring gene predicted gene, 53285 Neighboring gene Hipk2R16 erythroid cis-regulatory module Neighboring gene thromboxane A synthase 1, platelet Neighboring gene predicted gene, 33767 Neighboring gene predicted gene, 57771

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    NOT enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables SMAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables SMAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables virion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables virion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response, signal transduction by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA damage response, signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in SMAD protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within adult walking behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within anterior/posterior pattern specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic camera-type eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic retina morphogenesis in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in iris morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lens induction in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lung morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of JNK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within respiratory system process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in retina layer formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in smoothened signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within smoothened signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within thyroid gland development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within voluntary musculoskeletal movement IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with PML body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with PML body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in PML body TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of RNA polymerase II transcription regulator complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic stress granule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    homeodomain-interacting protein kinase 2
    Names
    nuclear body-associated kinase 1
    sialophorin tail-associated nuclear serine/threonine-protein kinase
    NP_001129537.1
    NP_001281072.1
    NP_001281073.1
    NP_034563.2
    XP_006505665.1
    XP_006505666.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136065.3NP_001129537.1  homeodomain-interacting protein kinase 2 isoform 1

      See identical proteins and their annotated locations for NP_001129537.1

      Status: VALIDATED

      Source sequence(s)
      AC118613, AC161147
      Consensus CDS
      CCDS51752.1
      UniProtKB/TrEMBL
      A0A0R4J204
      Related
      ENSMUSP00000125572.2, ENSMUST00000160962.8
      Conserved Domains (2) summary
      smart00220
      Location:192520
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14227
      Location:176530
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
    2. NM_001294143.2NP_001281072.1  homeodomain-interacting protein kinase 2 isoform 3

      See identical proteins and their annotated locations for NP_001281072.1

      Status: VALIDATED

      Source sequence(s)
      AC118613, AC154016, AC161147
      Consensus CDS
      CCDS80527.1
      UniProtKB/TrEMBL
      Q5D0E9
      Related
      ENSMUSP00000125150.2, ENSMUST00000162359.8
      Conserved Domains (2) summary
      smart00220
      Location:199527
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14227
      Location:183537
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
    3. NM_001294144.2NP_001281073.1  homeodomain-interacting protein kinase 2 isoform 4

      See identical proteins and their annotated locations for NP_001281073.1

      Status: VALIDATED

      Source sequence(s)
      AC118613, AC154016, AC161147
      Consensus CDS
      CCDS80526.1
      UniProtKB/TrEMBL
      A0A0R4J202
      Related
      ENSMUSP00000125500.2, ENSMUST00000160360.2
      Conserved Domains (2) summary
      smart00220
      Location:199527
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14227
      Location:183537
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
    4. NM_010433.3NP_034563.2  homeodomain-interacting protein kinase 2 isoform 2

      See identical proteins and their annotated locations for NP_034563.2

      Status: VALIDATED

      Source sequence(s)
      AC118613, AC154016, AC161147
      Consensus CDS
      CCDS20017.2
      UniProtKB/Swiss-Prot
      O88905, Q99P45, Q99P46, Q9D2E6, Q9D474, Q9EQL2, Q9QZR4, Q9QZR5
      Related
      ENSMUSP00000124133.2, ENSMUST00000161779.8
      Conserved Domains (2) summary
      smart00220
      Location:199527
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14227
      Location:183537
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      38664447..38853236 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505602.5XP_006505665.1  homeodomain-interacting protein kinase 2 isoform X1

      Conserved Domains (1) summary
      cd14227
      Location:183537
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
    2. XM_006505603.4XP_006505666.1  homeodomain-interacting protein kinase 2 isoform X2

      Conserved Domains (1) summary
      cd14227
      Location:176530
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2