Sox12 SRY (sex determining region Y)-box 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sox12provided by MGI
Official Full Name: SRY (sex determining region Y)-box 12provided by MGI
Primary source: MGI:MGI:98360
See related: Ensembl:ENSMUSG00000051817 AllianceGenome:MGI:98360
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2010205A02Rik
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Involved in positive regulation of regulatory T cell differentiation; positive regulation of transcription by RNA polymerase II; and spinal cord development. Part of protein-DNA complex. Is expressed in several structures, including alimentary system; genitourinary system; lung; nervous system; and sensory organ. Orthologous to human SOX12 (SRY-box transcription factor 12). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human all
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Genomic context

Location:: 2 G3; 2 74.94 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (152235531..152239966, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (152393611..152398046, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sox12 enhances Fbw7-mediated ubiquitination and degradation of GATA3 in Th2 cells.
Title: Sox12 enhances Fbw7-mediated ubiquitination and degradation of GATA3 in Th2 cells.
These results suggest that TCR-NFAT signaling induces the development of pT reg cells in colitic mice partly through Sox12 induction.
Title: Sox12 promotes T reg differentiation in the periphery during colitis.
SOXC proteins act cell- and non-cell-autonomously in perichondrocytes and chondrocytes to establish noncanonical WNT signaling crosstalk essential for growth plate induction and control
Title: SOXC Transcription Factors Induce Cartilage Growth Plate Formation in Mouse Embryos by Promoting Noncanonical WNT Signaling.
Study show that the survival of neural and mesenchymal progenitor cells critically relies on the redundantly acting SoxC transcription factors Sox4, Sox11 and Sox12.
Title: Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors.
Sox4 and Sox11 function redundantly with Sox12 and can compensate its loss during mouse development.
Title: Sox12 deletion in the mouse reveals nonreciprocal redundancy with the related Sox4 and Sox11 transcription factors.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in camera-type eye morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of regulatory T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in spinal cord development	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-DNA complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transcription factor SOX-12

Names: SRY-box containing gene 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011438.2 → NP_035568.1 transcription factor SOX-12

See identical proteins and their annotated locations for NP_035568.1

Status: VALIDATED

Source sequence(s)

AL928568, BG228657, BQ180104, CA749985, CB245116

Consensus CDS

CCDS38274.1

UniProtKB/Swiss-Prot

A2AS82, P70417, Q04890, Q6NXL2

Related

ENSMUSP00000138293.2, ENSMUST00000182625.2

Conserved Domains (1) summary

cd01388
Location:39 → 110

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...