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    UNK unk zinc finger [ Homo sapiens (human) ]

    Gene ID: 85451, updated on 10-Dec-2024

    Summary

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    Official Symbol
    UNKprovided by HGNC
    Official Full Name
    unk zinc fingerprovided by HGNC
    Primary source
    HGNC:HGNC:29369
    See related
    Ensembl:ENSG00000132478 MIM:616375; AllianceGenome:HGNC:29369
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZC3H5; UNKEMPT; ZC3HDC5
    Summary
    Enables mRNA CDS binding activity. Involved in cell morphogenesis involved in neuron differentiation and negative regulation of cytoplasmic translation. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 4.4), spleen (RPKM 4.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See UNK in Genome Data Viewer
    Location:
    17q25.1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (75784806..75825799)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (76678053..76718950)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73780887..73821880)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12776 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73774948-73775552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12777 Neighboring gene H3.3 histone B Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73780981-73781559 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73781560-73782137 Neighboring gene microRNA 4738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73810697-73811198 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73811199-73811698 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73812483-73812984 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73812985-73813484 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73825830-73826818 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73826819-73827806 Neighboring gene unc-13 homolog D Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73831316-73831816 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73832318-73833318 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73834667-73835166 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8986 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73840002-73840706 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12779 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12780 Neighboring gene WW domain binding protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12781 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8989 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:73852240-73853035

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Recognition of distinct RNA motifs by the clustered CCCH zinc fingers of neuronal protein Unkempt. Murn J, et al. Nat Struct Mol Biol, 2016 Jan. PMID 26641712, Free PMC Article
    2. Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling. Zuo Y, et al. Nat Commun, 2020 Mar 2. PMID 32123171, Free PMC Article
    3. Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation. Fan X, et al. Stem Cell Res Ther, 2021 Feb 4. PMID 33541421, Free PMC Article
    4. Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. Tao WA, et al. Nat Methods, 2005 Aug. PMID 16094384
    5. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2000 Dec 31. PMID 11214970

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1753

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables mRNA CDS binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA CDS binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell morphogenesis involved in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis involved in neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cytoplasmic translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RING finger protein unkempt homolog
    Names
    unk family zinc finger
    unkempt family zinc finger
    unkempt homolog
    zinc finger CCCH domain-containing protein 5
    zinc finger CCCH-type containing 5
    zinc finger CCCH-type domain containing 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080419.3 → NP_001073888.2  RING finger protein unkempt homolog

      See identical proteins and their annotated locations for NP_001073888.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the functional protein.
      Source sequence(s)
      AC087289, AK307289, BC053362
      Consensus CDS
      CCDS45778.2
      UniProtKB/Swiss-Prot
      Q9C0B0
      Related
      ENSP00000464893.1, ENST00000589666.6
      Conserved Domains (5) summary
      COG4372
      Location:653 → 758
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      COG5063
      Location:124 → 318
      CTH1; CCCH-type Zn-finger protein [General function prediction only]
      cd16614
      Location:768 → 801
      RING-HC_UNK_like; RING finger, HC subclass, found in RING finger protein unkempt (UNK), unkempt-like (UNKL), and similar proteins
      pfam00642
      Location:294 → 319
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam18384
      Location:34 → 69
      zf_CCCH_5; Unkempt Zinc finger domain 1 (Znf1)

    RNA

    1. NR_038131.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC087289, BC064927
      Related
      ENST00000586527.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      75784806..75825799
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436965.1 → XP_047292921.1  RING finger protein unkempt homolog isoform X4

    2. XM_011525400.2 → XP_011523702.1  RING finger protein unkempt homolog isoform X5

      See identical proteins and their annotated locations for XP_011523702.1

      Conserved Domains (4) summary
      smart00356
      Location:47 → 71
      ZnF_C3H1; zinc finger
      pfam00642
      Location:126 → 152
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam13863
      Location:478 → 554
      DUF4200; Domain of unknown function (DUF4200)
      pfam13920
      Location:597 → 633
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    3. XM_047436964.1 → XP_047292920.1  RING finger protein unkempt homolog isoform X3

    4. XM_047436962.1 → XP_047292918.1  RING finger protein unkempt homolog isoform X1

    5. XM_017025248.2 → XP_016880737.1  RING finger protein unkempt homolog isoform X1

      Conserved Domains (4) summary
      COG5063
      Location:153 → 347
      CTH1; CCCH-type Zn-finger protein [General function prediction only]
      pfam00642
      Location:323 → 349
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam13920
      Location:794 → 830
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
      cl21478
      Location:659 → 757
      ATP-synt_B; ATP synthase B/B' CF(0)

    6. XM_017025249.2 → XP_016880738.1  RING finger protein unkempt homolog isoform X4

    7. XM_047436963.1 → XP_047292919.1  RING finger protein unkempt homolog isoform X2

    8. XM_047436966.1 → XP_047292922.1  RING finger protein unkempt homolog isoform X5

    9. XM_006722148.3 → XP_006722211.1  RING finger protein unkempt homolog isoform X5

      See identical proteins and their annotated locations for XP_006722211.1

      Conserved Domains (4) summary
      smart00356
      Location:47 → 71
      ZnF_C3H1; zinc finger
      pfam00642
      Location:126 → 152
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam13863
      Location:478 → 554
      DUF4200; Domain of unknown function (DUF4200)
      pfam13920
      Location:597 → 633
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    10. XM_011525401.3 → XP_011523703.1  RING finger protein unkempt homolog isoform X6

      Conserved Domains (3) summary
      pfam00642
      Location:4 → 30
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam13863
      Location:356 → 432
      DUF4200; Domain of unknown function (DUF4200)
      pfam13920
      Location:475 → 511
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      76678053..76718950
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317617.1 → XP_054173592.1  RING finger protein unkempt homolog isoform X5

    2. XM_054317613.1 → XP_054173588.1  RING finger protein unkempt homolog isoform X3

    3. XM_054317615.1 → XP_054173590.1  RING finger protein unkempt homolog isoform X4

    4. XM_054317611.1 → XP_054173586.1  RING finger protein unkempt homolog isoform X1

    5. XM_054317614.1 → XP_054173589.1  RING finger protein unkempt homolog isoform X4

    6. XM_054317612.1 → XP_054173587.1  RING finger protein unkempt homolog isoform X2

    7. XM_054317616.1 → XP_054173591.1  RING finger protein unkempt homolog isoform X5

    8. XM_054317618.1 → XP_054173593.1  RING finger protein unkempt homolog isoform X5

    9. XM_054317619.1 → XP_054173594.1  RING finger protein unkempt homolog isoform X6

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C0B0.2 GenPept UniProtKB/Swiss-Prot:Q9C0B0

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