mu2 mutator 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: mu2provided by FlyBase
Official Full Name: mutator 2provided by FlyBase
Primary source: FLYBASE:FBgn0002872
Locus tag: Dmel_CG1960
See related: AllianceGenome:FB:FBgn0002872
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: cDNA D; CG1960; Dmel\CG1960; Mdc1; MDC1; mu-2; Mu2; MU2; mutator[2]
Summary: Enables transcription coactivator activity. Involved in double-strand break repair; positive regulation of transcription by RNA polymerase II; and regulation of pericentric heterochromatin formation. Located in chromosome, centromeric region and euchromatin. Is expressed in several structures, including eye disc morphogenetic furrow; germarium; imaginal disc; larval brain; and presumptive embryonic/larval central nervous system. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 62B11-62B11; 3-1.0 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (1942734..1947475, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (1942734..1947475, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

As compared to the MDC1 forkhead-associated FHA) domain, the MU2 FHA domain dimerizes using a different and more stable interface and contains a degenerate phosphothreonine-binding pocket.
Title: Dimerization, but not phosphothreonine binding, is conserved between the forkhead-associated domains of Drosophila MU2 and human MDC1.
The interplay between MU2 and HP1a is dynamic and may be different in euchromatin and heterochromatin during DNA break recognition and repair.
Title: MU2 and HP1a regulate the recognition of double strand breaks in Drosophila melanogaster.
MU2 participates at an early stage in the recognition of DNA damage at a step that is prerequisite for both DNA repair and cell cycle checkpoint control.
Title: Recognition of double strand breaks by a mutator protein (MU2) in Drosophila melanogaster.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables transcription coactivator activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of pericentric heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in euchromatin	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: mutator 2

Names: CG1960-PA; CG1960-PB; CG1960-PC; mu2-PA; mu2-PB; mu2-PC; mutator2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

1942734..1947475 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_167927.3 → NP_728695.1 mutator 2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728695.1

Status: REVIEWED

UniProtKB/TrEMBL

O96685, Q9W061

Related

FBpp0072736

Conserved Domains (1) summary

cl00038
Location:1058 → 1138

BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
NM_001169855.2 → NP_001163326.1 mutator 2, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163326.1

Status: REVIEWED

UniProtKB/TrEMBL

A2VEF9, O96685

Conserved Domains (1) summary

cl00038
Location:1073 → 1153

BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
NM_079163.4 → NP_523887.2 mutator 2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523887.2

Status: REVIEWED

UniProtKB/TrEMBL

O96685, Q95RC8

Related

FBpp0072735

Conserved Domains (1) summary

cl00038
Location:1079 → 1159

BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...