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    KAT3 potassium channel protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829400, updated on 18-Sep-2024

    Summary

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    Official Symbol
    KAT3
    Official Full Name
    potassium channel protein
    Primary source
    TAIR:AT4G32650
    Locus tag
    AT4G32650
    See related
    Araport:AT4G32650
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    A. thaliana low-K+-tolerant 1; ARABIDOPSIS THALIANA K+ RECTIFYING CHANNEL 1; ATKC1; AtLKT1; F4D11.150; F4D11_150; K+ INWARD RECTIFYING CHANNEL PROTEIN; KC1; potassium channel in Arabidopsis thaliana 3
    Summary
    Encodes KAT3, a member of the Shaker family of voltage-gated potassium channel subunits. Does not form functional potassium channel on its own. Involved in down-regulating AKT1 and KAT1 channel activity by forming heteromers with AKT1 or KAT1. The Shaker family K+ ion channels include five groups based on phylogenetic analysis (FEBS Letters (2007) 581: 2357): I (inwardly rectifying conductance): AKT1 (AT2G26650), AKT5 (AT4G32500) and SPIK (also known as AKT6, AT2G25600); II (inward rectifying channel): KAT1 (AT5G46240) and KAT2 (AT4G18290); III (weakly inward rectifying channel): AKT2 (AT4G22200); IV (regulatory subunit involved in inwardly rectifying conductance formation): KAT3 (also known as AtKC1, AT4G32650); V (outward rectifying channel): SKOR (AT3G02850) and GORK (AT5G37500).
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    Genomic context

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    See KAT3 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    13
    Sequence:
    Chromosome: 4; NC_003075.7 (15751271..15755047, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ArfGap/RecO-like zinc finger domain-containing protein Neighboring gene Sec23/Sec24 protein transport family protein Neighboring gene ncRNA Neighboring gene Protein kinase superfamily protein Neighboring gene RING/FYVE/PHD zinc finger superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AtKC1, a conditionally targeted Shaker-type subunit, regulates the activity of plant K+ channels. Duby G, et al. Plant J, 2008 Jan. PMID 17976154
    2. AtKC1 is a general modulator of Arabidopsis inward Shaker channel activity. Jeanguenin L, et al. Plant J, 2011 Aug. PMID 21518051
    3. A novel motif essential for SNARE interaction with the K(+) channel KC1 and channel gating in Arabidopsis. Grefen C, et al. Plant Cell, 2010 Sep. PMID 20884800, Free PMC Article
    4. Potassium channel alpha-subunit AtKC1 negatively regulates AKT1-mediated K(+) uptake in Arabidopsis roots under low-K(+) stress. Wang Y, et al. Cell Res, 2010 Jul. PMID 20514083
    5. A tripartite SNARE-K+ channel complex mediates in channel-dependent K+ nutrition in Arabidopsis. Honsbein A, et al. Plant Cell, 2009 Sep. PMID 19794113, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CIPK23 and AtKC1 exhibit distinct effects; however, they act synergistically and balance K(+) uptake/leakage to modulate AKT1-mediated low potassium responses in Arabidopsis.
      Title: AtKC1 and CIPK23 Synergistically Modulate AKT1-Mediated Low-Potassium Stress Responses in Arabidopsis.
    2. AtKC1-mediated channel activity regulation is required for normal plant growth.
      Title: AtKC1 is a general modulator of Arabidopsis inward Shaker channel activity.
    3. SNARE interaction with the KC1 K+ channel depends on the presence of the N terminus of SYP121.
      Title: A novel motif essential for SNARE interaction with the K(+) channel KC1 and channel gating in Arabidopsis.
    4. Electrophysiological results showed that AtKC1 inhibited the AKT1-mediated inward K(+) currents and negatively shifted the voltage dependence of AKT1 channels.
      Title: Potassium channel alpha-subunit AtKC1 negatively regulates AKT1-mediated K(+) uptake in Arabidopsis roots under low-K(+) stress.
    5. SYP121-KC1 interaction promotes K+ channel gating and activates K+ channel current and K+ uptake.
      Title: A tripartite SNARE-K+ channel complex mediates in channel-dependent K+ nutrition in Arabidopsis.
    6. AtKC1-AKT1 channels in Arabidopsis roots facilitate growth under K+-limiting conditions
      Title: Heteromeric AtKC1{middle dot}AKT1 channels in Arabidopsis roots facilitate growth under K+-limiting conditions.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001036696.1
    NM_119417.4
    NM_202936.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables inward rectifier potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within potassium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to nematode HEP PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    potassium channel protein
    NP_001031773.1
    • ARABIDOPSIS THALIANA K+ RECTIFYING CHANNEL 1 (ATKC1); CONTAINS InterPro DOMAIN/s: Cyclic nucleotide-binding (InterPro:IPR000595), Potassium channel, voltage-dependent, EAG/ELK/ERG (InterPro:IPR003938), Ion transport (InterPro:IPR005821), Cyclic nucleotide-binding-like (InterPro:IPR018490), RmlC-like jelly roll fold (InterPro:IPR014710), Protein of unknown function DUF3354 (InterPro:IPR021789); BEST Arabidopsis thaliana protein match is: K+ transporter 1 (TAIR:AT2G26650.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_194991.1
    • potassium channel in Arabidopsis thaliana 3 (KAT3); CONTAINS InterPro DOMAIN/s: Cyclic nucleotide-binding (InterPro:IPR000595), Potassium channel, voltage-dependent, EAG/ELK/ERG (InterPro:IPR003938), Cyclic nucleotide-binding-like (InterPro:IPR018490), Ion transport (InterPro:IPR005821), RmlC-like jelly roll fold (InterPro:IPR014710), Protein of unknown function DUF3354 (InterPro:IPR021789); BEST Arabidopsis thaliana protein match is: K+ transporter 1 (TAIR:AT2G26650.1); Has 6655 Blast hits to 6394 proteins in 956 species: Archae - 41; Bacteria - 1615; Metazoa - 2020; Fungi - 86; Plants - 876; Viruses - 0; Other Eukaryotes - 2017 (source: NCBI BLink).
    NP_974665.1
    • ARABIDOPSIS THALIANA K+ RECTIFYING CHANNEL 1 (ATKC1); CONTAINS InterPro DOMAIN/s: Cyclic nucleotide-binding (InterPro:IPR000595), Potassium channel, voltage-dependent, EAG/ELK/ERG (InterPro:IPR003938), Ion transport (InterPro:IPR005821), Cyclic nucleotide-binding-like (InterPro:IPR018490), RmlC-like jelly roll fold (InterPro:IPR014710); BEST Arabidopsis thaliana protein match is: K+ transporter 1 (TAIR:AT2G26650.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      15751271..15755047 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119417.4 → NP_194991.1  potassium channel protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194991.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P92960
      UniProtKB/TrEMBL
      A0A178UVX9, A0A5S9XYW1, A0A7G2F9A5
      Conserved Domains (2) summary
      PLN03192
      Location:51 → 532
      PLN03192; Voltage-dependent potassium channel; Provisional
      pfam11834
      Location:590 → 661
      KHA; dimerization domain of potassium ion channel

    2. NM_001036696.1 → NP_001031773.1  potassium channel protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031773.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2F9A5, F4JV33
      Conserved Domains (5) summary
      COG0664
      Location:400 → 511
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:406 → 519
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00520
      Location:111 → 335
      Ion_trans; Ion transport protein
      pfam07885
      Location:279 → 330
      Ion_trans_2; Ion channel
      pfam11834
      Location:589 → 660
      KHA; KHA, dimerization domain of potassium ion channel

    3. NM_202936.1 → NP_974665.1  potassium channel protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974665.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2F9A5, F4JV35
      Conserved Domains (4) summary
      COG0664
      Location:400 → 511
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:406 → 519
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00520
      Location:111 → 335
      Ion_trans; Ion transport protein
      pfam07885
      Location:279 → 330
      Ion_trans_2; Ion channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P92960.1

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