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    HB33 homeobox protein 33 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843861, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HB33
    Official Full Name
    homeobox protein 33
    Primary source
    TAIR:AT1G75240
    Locus tag
    AT1G75240
    See related
    Araport:AT1G75240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtHB33; F22H5.4; F22H5_4; homeobox protein 33; ZHD5; zinc-finger homeodomain 5
    Summary
    Encodes a zinc finger-homeodomain transcription factor ZHD5. Nuclear import and DNA binding of the ZHD5 transcription factor is modulated by a competitive peptide inhibitor MIF1 (AT1G74660).
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    Genomic context

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    See HB33 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    2
    Sequence:
    Chromosome: 1; NC_003070.9 (28241011..28242795)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase Neighboring gene Major facilitator superfamily protein Neighboring gene DNA glycosylase superfamily protein Neighboring gene RAD-like 6 Neighboring gene oxidoreductases, acting on NADH or NADPH

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Auxin Response Factor2 (ARF2) and its regulated homeodomain gene HB33 mediate abscisic acid response in Arabidopsis. Wang L, et al. PLoS Genet, 2011 Jul. PMID 21779177, Free PMC Article
    2. Nuclear import and DNA binding of the ZHD5 transcription factor is modulated by a competitive peptide inhibitor in Arabidopsis. Hong SY, et al. J Biol Chem, 2011 Jan 14. PMID 21059647, Free PMC Article
    3. The Arabidopsis zinc finger-homeodomain genes encode proteins with unique biochemical properties that are coordinately expressed during floral development. Tan QK, et al. Plant Physiol, 2006 Mar. PMID 16428600, Free PMC Article
    4. Promoter-based integration in plant defense regulation. Li B, et al. Plant Physiol, 2014 Dec. PMID 25352272, Free PMC Article
    5. A PXY-Mediated Transcriptional Network Integrates Signaling Mechanisms to Control Vascular Development in Arabidopsis. Smit ME, et al. Plant Cell, 2020 Feb. PMID 31806676, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ARF2 and HB33 are novel regulators in the abscissic acid signal pathway, which has crosstalk with auxin signal pathway in regulating plant growth.
      Title: Auxin Response Factor2 (ARF2) and its regulated homeodomain gene HB33 mediate abscisic acid response in Arabidopsis.
    2. observations indicate that MIF1 regulates the ZHD5 activities in a dual step manner: nuclear import and DNA binding. [ZHD5]
      Title: Nuclear import and DNA binding of the ZHD5 transcription factor is modulated by a competitive peptide inhibitor in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_106180.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    homeobox protein 33
    NP_565106.1
    • homeobox protein 33 (HB33); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription; LOCATED IN: cellular_component unknown; EXPRESSED IN: 16 plant structures; EXPRESSED DURING: 9 growth stages; CONTAINS InterPro DOMAIN/s: Homeobox domain, ZF-HD class (InterPro:IPR006455), ZF-HD homeobox protein, Cys/His-rich dimerisation domain (InterPro:IPR006456), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: homeobox protein 24 (TAIR:AT2G18350.1); Has 705 Blast hits to 675 proteins in 76 species: Archae - 0; Bacteria - 8; Metazoa - 117; Fungi - 10; Plants - 549; Viruses - 3; Other Eukaryotes - 18 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      28241011..28242795
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106180.4 → NP_565106.1  homeobox protein 33 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565106.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FRL5
      UniProtKB/TrEMBL
      A0A178WFZ4, A0A5S9WUI2
      Conserved Domains (2) summary
      TIGR01565
      Location:240 → 296
      homeo_ZF_HD; homeobox domain, ZF-HD class
      pfam04770
      Location:73 → 127
      ZF-HD_dimer; ZF-HD protein dimerization region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FRL5.1

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