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    RPP13 NB-ARC domain-containing disease resistance protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 823806, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RPP13
    Official Full Name
    NB-ARC domain-containing disease resistance protein
    Primary source
    TAIR:AT3G46530
    Locus tag
    AT3G46530
    See related
    Araport:AT3G46530
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    RECOGNITION OF PERONOSPORA PARASITICA 13
    Summary
    Confers resistance to the biotrophic oomycete, Peronospora parasitica. Encodes an NBS-LRR type R protein with a putative amino-terminal leucine zipper. Fungal protein ATR13 induces RPP13 gene expression and disease resistance.
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    Genomic context

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    See RPP13 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    1
    Sequence:
    Chromosome: 3; NC_003074.8 (17130300..17133462, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein Neighboring gene plant U-box 13 Neighboring gene actin-12 Neighboring gene ENTH/VHS family protein Neighboring gene ncRNA Neighboring gene Fasciclin-like arabinogalactan family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Natural variation reveals key amino acids in a downy mildew effector that alters recognition specificity by an Arabidopsis resistance gene. Allen RL, et al. Mol Plant Pathol, 2008 Jul. PMID 18705864, Free PMC Article
    2. Recognition of the Hyaloperonospora parasitica effector ATR13 triggers resistance against oomycete, bacterial, and viral pathogens. Rentel MC, et al. Proc Natl Acad Sci U S A, 2008 Jan 22. PMID 18198274, Free PMC Article
    3. RPP13 is a simple locus in Arabidopsis thaliana for alleles that specify downy mildew resistance to different avirulence determinants in Peronospora parasitica. Bittner-Eddy PD, et al. Plant J, 2000 Jan. PMID 10743658
    4. Interhomolog polymorphism shapes meiotic crossover within the Arabidopsis RAC1 and RPP13 disease resistance genes. Serra H, et al. PLoS Genet, 2018 Dec. PMID 30543623, Free PMC Article
    5. The downy mildew effector proteins ATR1 and ATR13 promote disease susceptibility in Arabidopsis thaliana. Sohn KH, et al. Plant Cell, 2007 Dec. PMID 18165328, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We mapped crossover hotspots located in the RAC1 and RPP13 disease resistance genes, using varying haplotypic combinations. We observed a negative non-linear relationship between interhomolog divergence and crossover frequency within the hotspots, consistent with polymorphism locally suppressing crossover repair of DSBs.
      Title: Interhomolog polymorphism shapes meiotic crossover within the Arabidopsis RAC1 and RPP13 disease resistance genes.
    2. Site-directed mutagenesis confirmed that a threonine residue is absolutely required for RPP13 recognition and that recognition can be modulated by the presence of either an arginine or glutamic acid at other sites.
      Title: Natural variation reveals key amino acids in a downy mildew effector that alters recognition specificity by an Arabidopsis resistance gene.
    3. Results conclude that ATR13 positively contribute to pathogen virulence inside host cells. [ATR13]
      Title: The downy mildew effector proteins ATR1 and ATR13 promote disease susceptibility in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_114520.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		  
    acts_upstream_of_or_within defense response to other organism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plant-type hypersensitive response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NB-ARC domain-containing disease resistance protein
    NP_190237.1
    • RECOGNITION OF PERONOSPORA PARASITICA 13 (RPP13); FUNCTIONS IN: ATP binding; INVOLVED IN: defense response, incompatible interaction, defense response, plant-type hypersensitive response; LOCATED IN: plasma membrane, cytoplasm; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: NB-ARC (InterPro:IPR002182), Disease resistance protein (InterPro:IPR000767); BEST Arabidopsis thaliana protein match is: NB-ARC domain-containing disease resistance protein (TAIR:AT3G46730.1); Has 13323 Blast hits to 13008 proteins in 390 species: Archae - 6; Bacteria - 196; Metazoa - 157; Fungi - 35; Plants - 12889; Viruses - 0; Other Eukaryotes - 40 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      17130300..17133462 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114520.3 → NP_190237.1  NB-ARC domain-containing disease resistance protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190237.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M667, Q9M668, Q9SNC5
      UniProtKB/TrEMBL
      A0A654FHF1, Q1KN28
      Conserved Domains (4) summary
      COG4886
      Location:561 → 722
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd14798
      Location:3 → 124
      RX-CC_like; Coiled-coil domain of the potato virux X resistance protein and similar proteins
      sd00033
      Location:587 → 611
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00931
      Location:166 → 398
      NB-ARC; NB-ARC domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M667.2

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