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    PNG1 peptide-N-glycanase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835019, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PNG1
    Official Full Name
    peptide-N-glycanase 1
    Primary source
    TAIR:AT5G49570
    Locus tag
    AT5G49570
    See related
    Araport:AT5G49570
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtPNG1; K6M13.12; K6M13_12; peptide-N-glycanase 1
    Summary
    Encodes a protein that has peptide:N-glycanase activity in enzymatic assay in heterologous systems (although the activity was not detected in wild-type plants).
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    Genomic context

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    See PNG1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    17
    Sequence:
    Chromosome: 5; NC_003076.8 (20111859..20116269, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene FAD/NAD(P)-binding oxidoreductase family protein Neighboring gene Putative methyltransferase family protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Chaperone DnaJ-domain superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AtPng1 knockout mutant of Arabidopsis thaliana shows a juvenile phenotype, morpho-functional changes, altered stress response and cell wall modifications. Serafini-Fracassini D, et al. Plant Physiol Biochem, 2021 Oct. PMID 34325356
    2. A plant peptide: N-glycanase orthologue facilitates glycoprotein ER-associated degradation in yeast. Masahara-Negishi Y, et al. Biochim Biophys Acta, 2012 Oct. PMID 22659524
    3. Plant and animal transglutaminases: do similar functions imply similar structures? Serafini-Fracassini D, et al. Amino Acids, 2009 Apr. PMID 18622667
    4. The Arabidopsis AtPNG1 gene encodes a peptide: N-glycanase. Diepold A, et al. Plant J, 2007 Oct. PMID 17666024
    5. AtPng1p. The first plant transglutaminase. Della Mea M, et al. Plant Physiol, 2004 Aug. PMID 15299133, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtPng1 knockout mutant of Arabidopsis thaliana shows a juvenile phenotype, morpho-functional changes, altered stress response and cell wall modifications.
      Title: AtPng1 knockout mutant of Arabidopsis thaliana shows a juvenile phenotype, morpho-functional changes, altered stress response and cell wall modifications.
    2. The plant PNGase facilitates ERAD through its deglycosylation activity, while the catalytic mutant of AtPNG1 impair glycoprotein ERAD by binding to N-glycans on the ERAD substrates.
      Title: A plant peptide: N-glycanase orthologue facilitates glycoprotein ER-associated degradation in yeast.
    3. AtPng1p, the first plant transglutaminase sequenced shows undetectable sequence homology to the animal enzymes, except for the catalytic triad. It is, however, endowed with a calcium-dependent activity that allowed us to build a three-dimensional model.
      Title: Plant and animal transglutaminases: do similar functions imply similar structures?
    4. the AtPng1p gene product acts as a transglutaminase; the first reported plant protein, characterized at molecular level showing TGase activity. [AtPng1p]
      Title: AtPng1p. The first plant transglutaminase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_124335.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to microbial phytotoxin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to ozone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salicylic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peptide-N-glycanase 1
    NP_199768.1
    • peptide-N-glycanase 1 (PNG1); CONTAINS InterPro DOMAIN/s: Transglutaminase-like (InterPro:IPR002931), DNA repair protein Rad4, transglutaminase-like domain (InterPro:IPR018325), Galactose-binding domain-like (InterPro:IPR008979); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      20111859..20116269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124335.3 → NP_199768.1  peptide-N-glycanase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199768.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q84WJ1, Q9FGY9
      UniProtKB/TrEMBL
      A0A654G9R0, A5PHD1
      Conserved Domains (3) summary
      pfam01841
      Location:199 → 296
      Transglut_core; Transglutaminase-like superfamily
      cl10615
      Location:280 → 347
      sm_acid_XPC-like; small acidic domain of Xeroderma pigmentosum group C complementing protein and similar proteins
      cl28922
      Location:16 → 63
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FGY9.1

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