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    FRA3 Endonuclease/exonuclease/phosphatase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842869, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FRA3
    Official Full Name
    Endonuclease/exonuclease/phosphatase family protein
    Primary source
    TAIR:AT1G65580
    Locus tag
    AT1G65580
    See related
    Araport:AT1G65580
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F5I14.11; F5I14_11; FRAGILE FIBER3
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    Genomic context

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    See FRA3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    11
    Sequence:
    Chromosome: 1; NC_003070.9 (24377263..24384086, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Pectin lyase-like superfamily protein Neighboring gene ncRNA Neighboring gene miscRNA Neighboring gene beta-hexosaminidase 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FRAGILE FIBER3, an Arabidopsis gene encoding a type II inositol polyphosphate 5-phosphatase, is required for secondary wall synthesis and actin organization in fiber cells. Zhong R, et al. Plant Cell, 2004 Dec. PMID 15539468, Free PMC Article
    2. MAPK target networks in Arabidopsis thaliana revealed using functional protein microarrays. Popescu SC, et al. Genes Dev, 2009 Jan 1. PMID 19095804, Free PMC Article
    3. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FRA3 type II 5PTase is involved in phosphoinositide metabolism and influences secondary wall synthesis and actin organization.[FRA3] [FRAGILE FIBER3]
      Title: FRAGILE FIBER3, an Arabidopsis gene encoding a type II inositol polyphosphate 5-phosphatase, is required for secondary wall synthesis and actin organization in fiber cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001334216.1
    NM_105232.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylinositol dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Endonuclease/exonuclease/phosphatase family protein
    NP_176736.2
    • FRAGILE FIBER3 (FRA3); FUNCTIONS IN: inositol or phosphatidylinositol phosphatase activity; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Inositol polyphosphate related phosphatase (InterPro:IPR000300), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat (InterPro:IPR001680), Endonuclease/exonuclease/phosphatase (InterPro:IPR005135); BEST Arabidopsis thaliana protein match is: Endonuclease/exonuclease/phosphatase family protein (TAIR:AT2G43900.1); Has 2602 Blast hits to 2499 proteins in 289 species: Archae - 0; Bacteria - 180; Metazoa - 887; Fungi - 607; Plants - 609; Viruses - 0; Other Eukaryotes - 319 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      24377263..24384086 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105232.3 → NP_176736.2  Endonuclease/exonuclease/phosphatase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176736.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04475, Q5MK18, Q84W55, Q9XFT1
      UniProtKB/TrEMBL
      A0A178WER9, A0A5S9WPM5, A0A654EMQ5
      Conserved Domains (4) summary
      cd09074
      Location:538 → 884
      INPP5c; Catalytic domain of inositol polyphosphate 5-phosphatases
      sd00039
      Location:413 → 442
      7WD40; WD40 repeat [structural motif]
      cl27657
      Location:919 → 1043
      Motile_Sperm; MSP (Major sperm protein) domain
      cl29593
      Location:182 → 510
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001334216.1 → NP_001321558.1  Endonuclease/exonuclease/phosphatase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AR99
      Conserved Domains (4) summary
      cd09074
      Location:272 → 618
      INPP5c; Catalytic domain of inositol polyphosphate 5-phosphatases
      sd00039
      Location:147 → 176
      7WD40; WD40 repeat [structural motif]
      cl27657
      Location:653 → 777
      Motile_Sperm; MSP (Major sperm protein) domain
      cl29593
      Location:155 → 244
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84W55.2

    Gene LinkOut

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