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    HCF164 Thioredoxin superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829874, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HCF164
    Official Full Name
    Thioredoxin superfamily protein
    Primary source
    TAIR:AT4G37200
    Locus tag
    AT4G37200
    See related
    Araport:AT4G37200
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AP22.37; AP22_37; HIGH CHLOROPHYLL FLUORESCENCE 164
    Summary
    Encodes thioredoxin-like protein with disulfide reductase activity that is involved in the biogenesis of the plastid cytochrome b6f complex. Protein is located in the thylakoid membrane with the C-terminal hydrophilic portion, containing the thioredoxin like domain, extending into the thylakoid lumen.
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    Genomic context

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    See HCF164 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    4
    Sequence:
    Chromosome: 4; NC_003075.7 (17509621..17511364, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene tRNA-Glu Neighboring gene Homeodomain-like superfamily protein Neighboring gene plasma membrane, autoregulation-binding site, misato segment II, myosin-like, tubulin/FtsZ protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene Cold acclimation protein WCOR413 family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HCF164 receives reducing equivalents from stromal thioredoxin across the thylakoid membrane and mediates reduction of target proteins in the thylakoid lumen. Motohashi K, et al. J Biol Chem, 2006 Nov 17. PMID 16997915
    2. HCF164 encodes a thioredoxin-like protein involved in the biogenesis of the cytochrome b(6)f complex in Arabidopsis. Lennartz K, et al. Plant Cell, 2001 Nov. PMID 11701887, Free PMC Article
    3. Identification of potential targets for thylakoid oxidoreductase AtVKOR/LTO1 in chloroplasts. Lu Y, et al. Protein Pept Lett, 2014. PMID 25412899
    4. A novel extended family of stromal thioredoxins. Cain P, et al. Plant Mol Biol, 2009 Jun. PMID 19259774
    5. New functions of the thylakoid membrane proteome of Arabidopsis thaliana revealed by a simple, fast, and versatile fractionation strategy. Peltier JB, et al. J Biol Chem, 2004 Nov 19. PMID 15322131

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results identified HCF164 as a direct target of LTO1 interacting with its thioredoxin-like domain suggesting that VKOR may play an important role in regulating the redox state of proteins in the thylakoid lume.
      Title: Identification of potential targets for thylakoid oxidoreductase AtVKOR/LTO1 in chloroplasts.
    2. This study suggests that HCF164 serves as an important transducer of reducing equivalents to proteins in the thylakoid lumen.
      Title: HCF164 receives reducing equivalents from stromal thioredoxin across the thylakoid membrane and mediates reduction of target proteins in the thylakoid lumen.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_119883.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cytochrome b6f complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    NOT located_in chloroplast stroma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast thylakoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast thylakoid membrane HDA PubMed 
    located_in chloroplast thylakoid membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in thylakoid lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Thioredoxin superfamily protein
    NP_195437.1
    • HIGH CHLOROPHYLL FLUORESCENCE 164 (HCF164); FUNCTIONS IN: oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor; INVOLVED IN: cytochrome b6f complex assembly; LOCATED IN: chloroplast thylakoid membrane, chloroplast, chloroplast thylakoid; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Thioredoxin, core (InterPro:IPR015467), Thioredoxin-like (InterPro:IPR017936), Thioredoxin domain (InterPro:IPR013766), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: thioredoxin X (TAIR:AT1G50320.1); Has 12708 Blast hits to 12383 proteins in 2440 species: Archae - 136; Bacteria - 7708; Metazoa - 1002; Fungi - 428; Plants - 950; Viruses - 3; Other Eukaryotes - 2481 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      17509621..17511364 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119883.3 → NP_195437.1  Thioredoxin superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195437.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23166
      UniProtKB/TrEMBL
      A0A178V430, A0A5S9Y1L4
      Conserved Domains (1) summary
      cd02950
      Location:119 → 260
      TxlA; TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O23166.2

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