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    IRX9 Nucleotide-diphospho-sugar transferases superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818285, updated on 18-Sep-2024

    Summary

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    Official Symbol
    IRX9
    Official Full Name
    Nucleotide-diphospho-sugar transferases superfamily protein
    Primary source
    TAIR:AT2G37090
    Locus tag
    AT2G37090
    See related
    Araport:AT2G37090
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    IRREGULAR XYLEM 9; T2N18.15; T2N18_15
    Summary
    The IRX9 gene encodes a putative family 43 glycosyl transferase. It was coordinately expressed with the cellulose synthase subunits during secondary cell wall formation. Cell wall analysis revealed a decrease in the abundance of xylan in the irx9 mutant, indicating that IRX9 is required for xylan synthesis. Mutants have irregular xylem phenotype suggesting a role in secondary cell wall biosynthesis.
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    Genomic context

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    See IRX9 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    3
    Sequence:
    Chromosome: 2; NC_003071.7 (15587394..15589369, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene TRIO/F-actin-binding protein Neighboring gene ROP interactive partner 3 Neighboring gene protamine P1 family protein Neighboring gene PLAC8 family protein Neighboring gene S1FA-like DNA-binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Organization of Xylan Production in the Golgi During Secondary Cell Wall Biosynthesis. Meents MJ, et al. Plant Physiol, 2019 Oct. PMID 31431513, Free PMC Article
    2. KNAT7 positively regulates xylan biosynthesis by directly activating IRX9 expression in Arabidopsis. He JB, et al. J Integr Plant Biol, 2018 Jun. PMID 29393579
    3. Arabidopsis family GT43 members are xylan xylosyltransferases required for the elongation of the xylan backbone. Lee C, et al. Plant Cell Physiol, 2012 Jan. PMID 22080591
    4. Molecular characterization of PoGT8D and PoGT43B, two secondary wall-associated glycosyltransferases in poplar. Zhou GK, et al. Plant Cell Physiol, 2007 May. PMID 17379696
    5. Arabidopsis irregular xylem8 and irregular xylem9: implications for the complexity of glucuronoxylan biosynthesis. Peña MJ, et al. Plant Cell, 2007 Feb. PMID 17322407, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Organization of Xylan Production in the Golgi During Secondary Cell Wall Biosynthesis.
      Title: Organization of Xylan Production in the Golgi During Secondary Cell Wall Biosynthesis.
    2. KNAT7 activates the promoters of the xylan biosynthetic genes, IRREGULAR XYLEM 9 (IRX9), IRX10, IRREGULAR XYLEM 14-LIKE (IRX14L), and FRAGILE FIBER 8 (FRA8).
      Title: KNAT7 positively regulates xylan biosynthesis by directly activating IRX9 expression in Arabidopsis.
    3. The putative glycosyltransferases IRX9, IRX14, and IRX10 (or the paralogs IRX9L, IRX14L, and IRX10L) are required for xylan backbone synthesis in Arabidopsis.
      Title: Site-directed mutagenesis of IRX9, IRX9L and IRX14 proteins involved in xylan biosynthesis: glycosyltransferase activity is not required for IRX9 function in Arabidopsis.
    4. The enzymatic activities of two Arabidopsis thaliana GT43 members, IRX9 (Irregular Xylem9) and IRX14, were investigated.
      Title: Arabidopsis family GT43 members are xylan xylosyltransferases required for the elongation of the xylan backbone.
    5. Double mutations of IRX9 and IRX14 were shown to cause a loss of secondary wall thickening in fibers and a much more severe reduction in glucuronoxylan synthesis.
      Title: The Arabidopsis family GT43 glycosyltransferases form two functionally nonredundant groups essential for the elongation of glucuronoxylan backbone.
    6. Results suggest that IRREGULAR XYLEM9 (IRX9) is required for normal glucuronoxylan (GX)elongation and indicate roles for IRX8 and FRA8 in the synthesis of the glycosyl sequence at the GX reducing end.
      Title: Arabidopsis irregular xylem8 and irregular xylem9: implications for the complexity of glucuronoxylan biosynthesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_129265.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 1,4-beta-D-xylan synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables xylosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within glucuronoxylan biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within glucuronoxylan metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plant-type secondary cell wall biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within xylan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Nucleotide-diphospho-sugar transferases superfamily protein
    NP_181246.1
    • IRREGULAR XYLEM 9 (IRX9); CONTAINS InterPro DOMAIN/s: Glycosyl transferase, family 43 (InterPro:IPR005027); BEST Arabidopsis thaliana protein match is: Nucleotide-diphospho-sugar transferases superfamily protein (TAIR:AT1G27600.2); Has 591 Blast hits to 584 proteins in 85 species: Archae - 0; Bacteria - 0; Metazoa - 323; Fungi - 0; Plants - 254; Viruses - 0; Other Eukaryotes - 14 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      15587394..15589369 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129265.3 → NP_181246.1  Nucleotide-diphospho-sugar transferases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181246.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9ZQC6
      UniProtKB/TrEMBL
      A0A178VRM9, A0A654F4V5, W8QNT8
      Conserved Domains (1) summary
      PLN02458
      Location:1 → 350
      PLN02458; transferase, transferring glycosyl groups
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZQC6.1

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