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    URE urease [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843076, updated on 18-Sep-2024

    Summary

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    Official Symbol
    URE
    Official Full Name
    urease
    Primary source
    TAIR:AT1G67550
    Locus tag
    AT1G67550
    See related
    Araport:AT1G67550
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F12B7.10; F12B7_10; urease
    Summary
    Encodes a nickel-containing urea hydrolase involved in nitrogen recycling. It requires three urease accessory proteins for its activation.
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    Genomic context

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    See URE in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    18
    Sequence:
    Chromosome: 1; NC_003070.9 (25312660..25317495)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene lectin protein kinase family protein Neighboring gene ARM repeat superfamily protein Neighboring gene uncharacterized protein Neighboring gene PLAT/LH2 domain-containing lipoxygenase family protein Neighboring gene zinc finger CONSTANS-like protein (DUF3537) Neighboring gene Protein kinase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Adverse effect of urease on salt stress during seed germination in Arabidopsis thaliana. Bu Y, et al. FEBS Lett, 2015 May 22. PMID 25907538
    2. The assembly of the plant urease activation complex and the essential role of the urease accessory protein G (UreG) in delivery of nickel to urease. Myrach T, et al. J Biol Chem, 2017 Sep 1. PMID 28710280, Free PMC Article
    3. Identification of three urease accessory proteins that are required for urease activation in Arabidopsis. Witte CP, et al. Plant Physiol, 2005 Nov. PMID 16244137, Free PMC Article
    4. The ureide-degrading reactions of purine ring catabolism employ three amidohydrolases and one aminohydrolase in Arabidopsis, soybean, and rice. Werner AK, et al. Plant Physiol, 2013 Oct. PMID 23940254, Free PMC Article
    5. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data (including data from studies using transgenic plants or cells from transgenic plants) suggest crucial role for UreG in nickel delivery for urease multimerization/activation. These studies were conducted using recombinant Arabidopsis thaliana proteins expressed in transgenic Nicotiana benthamiana cloned cells or hydroponic plants. (UreG = urease accessory protein UreG)
      Title: The assembly of the plant urease activation complex and the essential role of the urease accessory protein G (UreG) in delivery of nickel to urease.
    2. Data (including data from genetically modified plants) suggest that the level of urease activity plays important role during seed germination and salt-tolerance.
      Title: Adverse effect of urease on salt stress during seed germination in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_105422.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables nickel cation binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables urease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables urease activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in urea catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    part_of urease complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    urease
    NP_176922.1
    • urease (URE); CONTAINS InterPro DOMAIN/s: Urease, alpha subunit (InterPro:IPR005848), Urease, alpha subunit, conserved site (InterPro:IPR017950), Amidohydrolase 1 (InterPro:IPR006680), Urease, alpha/gamma subunit (InterPro:IPR002026), Urease, alpha subunit, core (InterPro:IPR017952), Metal-dependent hydrolase, composite domain (InterPro:IPR011059), Urease, beta subunit (InterPro:IPR002019), Urease (InterPro:IPR008221), Urease, alpha subunit, C-terminal (InterPro:IPR017951), Urease alpha-subunit, N-terminal (InterPro:IPR011612); Has 10097 Blast hits to 10094 proteins in 1139 species: Archae - 93; Bacteria - 7117; Metazoa - 16; Fungi - 228; Plants - 47; Viruses - 0; Other Eukaryotes - 2596 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      25312660..25317495
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105422.4 → NP_176922.1  urease [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176922.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SR52
      UniProtKB/TrEMBL
      A0A178WBS1, A0A5S9WQL7, A0A654EM62
      Conserved Domains (1) summary
      PLN02303
      Location:1 → 838
      PLN02303; urease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SR52.1

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