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    Ilrun inflammation and lipid regulator with UBA-like and NBR1-like domains [ Mus musculus (house mouse) ]

    Gene ID: 224647, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ilrunprovided by MGI
    Official Full Name
    inflammation and lipid regulator with UBA-like and NBR1-like domainsprovided by MGI
    Primary source
    MGI:MGI:106281
    See related
    Ensembl:ENSMUSG00000056692 AllianceGenome:MGI:106281
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D17Wsu92e; C030010A15
    Summary
    Predicted to enable ubiquitin binding activity. Predicted to be involved in several processes, including negative regulation of cytokine production; negative regulation of defense response to virus; and negative regulation of protein localization to nucleus. Predicted to be located in centrosome; cytosol; and nuclear speck. Predicted to be active in phagophore assembly site. Is expressed in several structures, including alimentary system; eye; genitourinary system; integumental system; and nervous system. Orthologous to human ILRUN (inflammation and lipid regulator with UBA-like and NBR1-like domains). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 61.3), liver adult (RPKM 60.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ilrun in Genome Data Viewer
    Location:
    17 A3.3; 17 14.59 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (27970206..28039516, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (27751232..27820542, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene protein kinase C and casein kinase substrate in neurons 1 Neighboring gene STARR-seq mESC enhancer starr_42171 Neighboring gene SAM pointed domain containing ets transcription factor Neighboring gene ribosomal protein S2, pseudogene 9 Neighboring gene STARR-seq mESC enhancer starr_42174 Neighboring gene STARR-positive B cell enhancer ABC_E2475 Neighboring gene STARR-positive B cell enhancer ABC_E4198 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27976840-27977098 Neighboring gene U1 small nuclear ribonucleoprotein C Neighboring gene bridge-like lipid transfer protein family member 3A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel role for the immunomodulator ILRUN in the development of several T cell subsets in mice. Tribolet L, et al. Immunobiology, 2023 May. PMID 37031606
    2. ILRUN Promotes Atherosclerosis Through Lipid-Dependent and Lipid-Independent Factors. Bi X, et al. Arterioscler Thromb Vasc Biol, 2022 Sep. PMID 35861973, Free PMC Article
    3. ILRUN, a Human Plasma Lipid GWAS Locus, Regulates Lipoprotein Metabolism in Mice. Bi X, et al. Circ Res, 2020 Nov 6. PMID 32912065, Free PMC Article
    4. Genomic structure and chromosomal mapping of the mouse transcription factor TEF-5 (Tead3) gene. Jacquemin P, et al. Mamm Genome, 1999 Jun. PMID 10341100
    5. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ILRUN Promotes Atherosclerosis Through Lipid-Dependent and Lipid-Independent Factors.
      Title: ILRUN Promotes Atherosclerosis Through Lipid-Dependent and Lipid-Independent Factors.
    2. ILRUN, a Human Plasma Lipid GWAS Locus, Regulates Lipoprotein Metabolism in Mice.
      Title: ILRUN, a Human Plasma Lipid GWAS Locus, Regulates Lipoprotein Metabolism in Mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in macroautophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of defense response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein localization to nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of tumor necrosis factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of type I interferon production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein ILRUN
    Names
    uncharacterized protein C6orf106 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033279.3 → NP_001028451.2  protein ILRUN isoform 1

      See identical proteins and their annotated locations for NP_001028451.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC131799, AK161603
      Consensus CDS
      CCDS28569.1
      UniProtKB/Swiss-Prot
      A2RT11, Q3TT38
      UniProtKB/TrEMBL
      B2KF52
      Related
      ENSMUSP00000110513.3, ENSMUST00000114863.10
      Conserved Domains (2) summary
      cd14349
      Location:23 → 64
      UBA_CF106; UBA-like domain found in uncharacterized protein C6orf106 and similar proteins
      cd14947
      Location:71 → 180
      NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins

    2. NM_001044719.2 → NP_001038184.1  protein ILRUN isoform 2

      See identical proteins and their annotated locations for NP_001038184.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC131799, BC137573
      Consensus CDS
      CCDS37523.1
      UniProtKB/TrEMBL
      A0A3B2W3W9, B2KF54
      Related
      ENSMUSP00000110509.2, ENSMUST00000114859.9
      Conserved Domains (2) summary
      cd14349
      Location:23 → 64
      UBA_CF106; UBA-like domain found in uncharacterized protein C6orf106 and similar proteins
      cd14947
      Location:71 → 180
      NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins

    3. NM_001271511.1 → NP_001258440.1  protein ILRUN isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to variant 1.
      Source sequence(s)
      AC131799, AK161603, BY755073
      Consensus CDS
      CCDS89036.1
      UniProtKB/TrEMBL
      A0A3B2WCT9
      Related
      ENSMUSP00000156684.2, ENSMUST00000233508.2
      Conserved Domains (2) summary
      cd14349
      Location:23 → 64
      UBA_CF106; UBA-like domain found in uncharacterized protein C6orf106 and similar proteins
      cd14947
      Location:71 → 170
      NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      27970206..28039516 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TT38.2 GenPept UniProtKB/Swiss-Prot:Q3TT38

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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