Cthrc1 collagen triple helix repeat containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cthrc1provided by MGI
Official Full Name: collagen triple helix repeat containing 1provided by MGI
Primary source: MGI:MGI:1915838
See related: Ensembl:ENSMUSG00000054196 AllianceGenome:MGI:1915838
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110014B07Rik
Summary: Enables Wnt-protein binding activity and frizzled binding activity. Acts upstream of or within several processes, including establishment of planar polarity involved in neural tube closure; inner ear development; and negative regulation of canonical Wnt signaling pathway. Located in sarcoplasm. Is expressed in several structures, including central nervous system; genitourinary system; heart; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in Barrett's esophagus. Orthologous to human CTHRC1 (collagen triple helix repeat containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in limb E14.5 (RPKM 91.9), CNS E14 (RPKM 19.0) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 B3.1; 15 15.35 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (38940327..38950516)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (39076932..39087121)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activated CTHRC1 promotes glycolysis in endothelial cells: Implications for metabolism and angiogenesis.
Title: Activated CTHRC1 promotes glycolysis in endothelial cells: Implications for metabolism and angiogenesis.
CTHRC1 promotes anaplastic thyroid cancer progression by upregulating the proliferation, migration, and invasion of tumor cells.
Title: CTHRC1 promotes anaplastic thyroid cancer progression by upregulating the proliferation, migration, and invasion of tumor cells.
Collagen Triple Helix Repeat Containing 1 Deficiency Protects Against Airway Remodeling and Inflammation in Asthma Models In Vivo and In Vitro.
Title: Collagen Triple Helix Repeat Containing 1 Deficiency Protects Against Airway Remodeling and Inflammation in Asthma Models In Vivo and In Vitro.
Cthrc1 deficiency aggravates wound healing and promotes cardiac rupture after myocardial infarction via non-canonical WNT5A signaling pathway.
Title: Cthrc1 deficiency aggravates wound healing and promotes cardiac rupture after myocardial infarction via non-canonical WNT5A signaling pathway.
GPR180 is a component of TGFbeta signalling that promotes thermogenic adipocyte function and mediates the metabolic effects of the adipocyte-secreted factor CTHRC1.
Title: GPR180 is a component of TGFβ signalling that promotes thermogenic adipocyte function and mediates the metabolic effects of the adipocyte-secreted factor CTHRC1.
The role of CTHRC1 in hair follicle regenerative capacity restored by plantar dermis homogenate.
Title: The role of CTHRC1 in hair follicle regenerative capacity restored by plantar dermis homogenate.
Single-Cell RNA Sequencing Analysis Reveals a Crucial Role for CTHRC1 (Collagen Triple Helix Repeat Containing 1) Cardiac Fibroblasts After Myocardial Infarction.
Title: Single-Cell RNA Sequencing Analysis Reveals a Crucial Role for CTHRC1 (Collagen Triple Helix Repeat Containing 1) Cardiac Fibroblasts After Myocardial Infarction.
Biochemical and structural cues of 3D-printed matrix synergistically direct MSC differentiation for functional sweat gland regeneration.
Title: Biochemical and structural cues of 3D-printed matrix synergistically direct MSC differentiation for functional sweat gland regeneration.
the binding of osteoclast-derived CTHRC1 to WAIF1 in stromal cells activates PKCdelta-ERK osteoblastogenic signaling.
Title: WAIF1 Is a Cell-Surface CTHRC1 Binding Protein Coupling Bone Resorption and Formation.
CTHRC1 secreted from osteocytes and osteoblasts functions as an inhibitor of osteoclast differentiation via inhibition of NFkappaB-dependent signaling.
Title: Inhibition of osteoclast differentiation and collagen antibody-induced arthritis by CTHRC1.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8) 1 citation
Targeted (6) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Wnt-protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables frizzled binding	IPI Inferred from Physical Interaction more info	PubMed
enables prostaglandin-endoperoxide synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cochlea morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cyclooxygenase pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within establishment of planar polarity involved in neural tube closure	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within inner ear receptor cell stereocilium organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within ossification involved in bone remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of osteoblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of osteoblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular space	HDA more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: collagen triple helix repeat-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001364812.1 → NP_001351741.1 collagen triple helix repeat-containing protein 1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC164883

Consensus CDS

CCDS88754.1

UniProtKB/TrEMBL

A0A2I3BPR1, B7ZMQ8

Related

ENSMUSP00000153886.2, ENSMUST00000226433.2
NM_001364813.1 → NP_001351742.1 collagen triple helix repeat-containing protein 1 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC164883

UniProtKB/TrEMBL

A2RRY6

Conserved Domains (1) summary

pfam01391
Location:59 → 91

Collagen; Collagen triple helix repeat (20 copies)
NM_026778.3 → NP_081054.1 collagen triple helix repeat-containing protein 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_081054.1

Status: VALIDATED

Source sequence(s)

AK151282, CD741549

Consensus CDS

CCDS27442.1

UniProtKB/Swiss-Prot

Q3UAP6, Q9D1D6

UniProtKB/TrEMBL

A2RRY6

Related

ENSMUSP00000070018.4, ENSMUST00000067072.5

Conserved Domains (1) summary

pfam01391
Location:59 → 91

Collagen; Collagen triple helix repeat (20 copies)