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    ablim3 actin binding LIM protein family, member 3 [ Danio rerio (zebrafish) ]

    Gene ID: 566821, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ablim3provided by ZNC
    Official Full Name
    actin binding LIM protein family, member 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070112-1122
    See related
    Ensembl:ENSDARG00000088168 AllianceGenome:ZFIN:ZDB-GENE-070112-1122
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb51g06; im:7152284; wu:fb51g06; zgc:158673; zgc:198293; si:dkey-23o10.3
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in cilium assembly and lamellipodium assembly. Predicted to act upstream of or within cytoskeleton organization. Predicted to be located in cytoplasm. Predicted to be active in stress fiber. Is expressed in notochord and somite. Orthologous to human ABLIM3 (actin binding LIM protein family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ablim3 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (34634140..34771916, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (34295075..34431624, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene actin filament associated protein 1-like 1a Neighboring gene PTTG1 regulator of sister chromatid separation, securin Neighboring gene uncharacterized LOC137487531 Neighboring gene SH3 domain and tetratricopeptide repeats 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics. Cao J, et al. Nat Cell Biol, 2012 Jun 10. PMID 22684256
    2. Evolution and expression of the phosphodiesterase 6 genes unveils vertebrate novelty to control photosensitivity. Lagman D, et al. BMC Evol Biol, 2016 Jun 13. PMID 27296292, Free PMC Article
    3. A novel inducible mutagenesis screen enables to isolate and clone both embryonic and adult zebrafish mutants. Ma Z, et al. Sci Rep, 2017 Sep 4. PMID 28871129, Free PMC Article
    4. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC198293

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    actin-binding LIM protein 3
    Names
    actin-binding LIM protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080598.1 → NP_001074067.1  actin-binding LIM protein 3

      See identical proteins and their annotated locations for NP_001074067.1

      Status: PROVISIONAL

      Source sequence(s)
      BC129372
      UniProtKB/TrEMBL
      A0A8M9QB40, A0A8N7UYL2, A1L269, F1R1G1
      Related
      ENSDARP00000116596.2, ENSDART00000141157.5
      Conserved Domains (6) summary
      smart00153
      Location:648 → 683
      VHP; Villin headpiece domain
      cd09327
      Location:23 → 74
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79 → 134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:152 → 203
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:211 → 266
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:294 → 647
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      34634140..34771916 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005173321.5 → XP_005173378.1  actin-binding LIM protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A0R4IXJ5, A0A8M2BL22, A0A8M9QB40
      Related
      ENSDARP00000140642.2, ENSDART00000160598.2
      Conserved Domains (6) summary
      smart00153
      Location:649 → 684
      VHP; Villin headpiece domain
      cd09327
      Location:24 → 75
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:80 → 135
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:153 → 204
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:212 → 267
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:295 → 648
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    RNA

    1. XR_011006101.1 RNA Sequence

    2. XR_011006098.1 RNA Sequence

    3. XR_011006102.1 RNA Sequence

    4. XR_011006100.1 RNA Sequence

    5. XR_011006099.1 RNA Sequence

    6. XR_011006097.1 RNA Sequence

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394919.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      136208..267253 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395317.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      138254..269168 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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