tmem237a transmembrane protein 237a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tmem237aprovided by ZNC
Official Full Name: transmembrane protein 237aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070402-3
See related: Ensembl:ENSDARG00000041735 AllianceGenome:ZFIN:ZDB-GENE-070402-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: als2cr4; als2cr4a; si:dkey-33m14.6
Summary: Acts upstream of or within convergent extension involved in gastrulation. Predicted to be located in ciliary transition zone. Is expressed in nervous system; pectoral fin; pectoral fin bud; and pharyngeal arch 3-7. Human ortholog(s) of this gene implicated in Joubert syndrome and Joubert syndrome 14. Orthologous to human TMEM237 (transmembrane protein 237). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (13714383..13728937)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (13743193..13757734)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within convergent extension involved in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in ciliary transition zone	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary transition zone	ISS Inferred from Sequence or Structural Similarity more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transmembrane protein 237A

Names: amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 4; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 4a; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001319136.1 → NP_001306065.1 transmembrane protein 237A

Status: VALIDATED

Source sequence(s)

BX571704, EH453111, EH461056

UniProtKB/Swiss-Prot

F1Q930

Related

ENSDARP00000007797.6, ENSDART00000017593.8

Conserved Domains (1) summary

pfam15383
Location:116 → 353

TMEM237; Transmembrane protein 237

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007120.7 Reference GRCz11 Primary Assembly

Range

13714383..13728937

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068223389.1 → XP_068079490.1 transmembrane protein 237A isoform X1
XM_021478686.2 → XP_021334361.1 transmembrane protein 237A isoform X3

UniProtKB/TrEMBL

A0A8M9QFF9

Conserved Domains (1) summary

pfam15383
Location:121 → 358

TMEM237; Transmembrane protein 237
XM_068223390.1 → XP_068079491.1 transmembrane protein 237A isoform X2