Ctrl chymotrypsin-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ctrlprovided by MGI
Official Full Name: chymotrypsin-likeprovided by MGI
Primary source: MGI:MGI:88558
See related: Ensembl:ENSMUSG00000031896 AllianceGenome:MGI:88558
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ctra1; Ctra-1; mFLJ00366; chymopasin; 0910001G08Rik; 1810004D15Rik
Summary: Enables peptidase activity. Acts upstream of or within proteolysis. Is expressed in brain; embryo; pancreas; and pancreas tip epithelium. Orthologous to human CTRL (chymotrypsin like). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in small intestine adult (RPKM 3550.0), spleen adult (RPKM 1859.9) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 D3; 8 53.06 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (106658626..106660494, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (105931994..105933862, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Secretagogue-induced pancreatitis in mice devoid of chymotrypsin.
Title: Secretagogue-induced pancreatitis in mice devoid of chymotrypsin.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

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Markers

AV005227 (e-PCR)
- UniSTS:164387

Ctrl (e-PCR), detects polymorphism
- UniSTS:531086

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type peptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: chymotrypsin-like protease CTRL-1

Names: chymotrypsin A CTRA-1

NP_075671.1

EC 3.4.21.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023182.2 → NP_075671.1 chymotrypsin-like protease CTRL-1 precursor

See identical proteins and their annotated locations for NP_075671.1

Status: VALIDATED

Source sequence(s)

AB016228, CF582693

Consensus CDS

CCDS22620.1

UniProtKB/TrEMBL

Q9D7P8, Q9D960, Q9ER05

Related

ENSMUSP00000034368.7, ENSMUST00000034368.8

Conserved Domains (2) summary

smart00020
Location:33 → 257

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:34 → 260

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...