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    IBTK inhibitor of Bruton tyrosine kinase [ Numida meleagris (helmeted guineafowl) ]

    Gene ID: 110395801, updated on 15-Mar-2024

    Summary

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    Gene symbol
    IBTK
    Gene description
    inhibitor of Bruton tyrosine kinase
    See related
    Ensembl:ENSNMEG00000011558
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Numida meleagris
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Numididae; Numida
    Orthologs
    human mouse all
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    Genomic context

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    See IBTK in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    100 current NumMel1.0 (GCF_002078875.1) 3 NC_034411.1 (78367832..78426406)

    Chromosome 3 - NC_034411.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110396528 Neighboring gene uncharacterized LOC110396527 Neighboring gene trophoblast glycoprotein Neighboring gene uncharacterized LOC110395534 Neighboring gene uncharacterized LOC110395533 Neighboring gene uncharacterized LOC110395535

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_034411.1 Chromosome 3 Reference NumMel1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein tyrosine kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inhibitor of Bruton tyrosine kinase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Numida meleagris Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NumMel1.0 Primary Assembly

    Genomic

    1. NC_034411.1 Reference NumMel1.0 Primary Assembly

      Range
      78367832..78426406
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021390673.1 → XP_021246348.1  inhibitor of Bruton tyrosine kinase

      Related
      ENSNMEP00000012487.1, ENSNMET00000019335.1
      Conserved Domains (5) summary
      cd00204
      Location:47 → 136
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14821
      Location:870 → 915
      SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
      sd00045
      Location:51 → 83
      ANK; ANK repeat [structural motif]
      pfam00651
      Location:759 → 870
      BTB; BTB/POZ domain
      cl27697
      Location:145 → 317
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    2. XM_021390674.1 → XP_021246349.1  inhibitor of Bruton tyrosine kinase

      Related
      ENSNMEP00000012486.1, ENSNMET00000019334.1
      Conserved Domains (5) summary
      cd00204
      Location:47 → 136
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14821
      Location:870 → 915
      SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
      sd00045
      Location:51 → 83
      ANK; ANK repeat [structural motif]
      pfam00651
      Location:759 → 870
      BTB; BTB/POZ domain
      cl27697
      Location:145 → 317
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    RNA

    1. XR_002436633.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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