Ebag9 estrogen receptor-binding fragment-associated gene 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ebag9provided by MGI
Official Full Name: estrogen receptor-binding fragment-associated gene 9provided by MGI
Primary source: MGI:MGI:1859920
See related: Ensembl:ENSMUSG00000022339 AllianceGenome:MGI:1859920
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rcas1
Summary: Acts upstream of or within T cell mediated cytotoxicity and adaptive immune memory response involving T cells and B cells. Located in Golgi apparatus. Is expressed in several structures, including central nervous system; genitourinary system; retina; spleen; and submandibular gland primordium epithelium. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human EBAG9 (estrogen receptor binding site associated antigen 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 3.4), bladder adult (RPKM 3.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 B3.2; 15 16.91 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (44482574..44504916)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (44619227..44641538)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RCAS1 increases cell morphological changes in murine fibroblasts by reducing p38 phosphorylation.
Title: RCAS1 increases cell morphological changes in murine fibroblasts by reducing p38 phosphorylation.
EBAG9 overexpression can be causative in enhancing the malignant properties of tumor cells.
Title: Intracellular estrogen receptor-binding fragment-associated antigen 9 exerts in vivo tumor-promoting effects via its coiled-coil region.
In the RCAS1 siRNA group, blood pressure was raised whereas urine albumin/creatinine ratio was increased. Our results suggest the importance of RCAS1 protein in the pathophysiologic condition of preeclampsia
Title: The effect of tumor-associated protein RCAS1 gene silencing on blood pressure and urinary protein excretion in pregnant mouse: a pilot study.
findings show RCAS1 induced cytochrome c release & activation of caspase-3 for apoptosis; cyclin D3 decreased significantly; results suggest cyclin D3 is one of key target molecules in RCAS1-RCAS1-R signaling pathway
Title: Analysis of cell cycle arrest and apoptosis induced by RCAS1.
In normal pregnant mice, RCAS1 protein mRNA was significantly increased on day 7.5 p.c. Antigen localization was detected in the placenta, decidua, and fetus.
Title: Temporal and spatial expression of tumor-associated antigen RCAS1 in pregnant mouse uterus.
EBAG9 is a tunable inhibitor of CTL-mediated adaptive immune response functions.
Title: The tumor-associated antigen EBAG9 negatively regulates the cytolytic capacity of mouse CD8+ T cells.
EBAG9 promoted primary 4T1 mammary carcinoma growth and distant metastasis, and EBAG9 small interfering RNA exerted overt regression of tumor growth and metastasis
Title: EBAG9 inducing hyporesponsiveness of T cells promotes tumor growth and metastasis in 4T1 murine mammary carcinoma.
EBAG9 may have a role in promoting progression of bladder cancer
Title: EBAG9 is a tumor-promoting and prognostic factor for bladder cancer.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI835379 (e-PCR)
- UniSTS:165923

RH137875 (e-PCR)
- UniSTS:219962

NoName (e-PCR)
- UniSTS:491417

Ebag9 (e-PCR), detects polymorphism
- UniSTS:532422

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell mediated cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adaptive immune memory response involving T cells and B cells	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within granzyme A production	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: receptor-binding cancer antigen expressed on SiSo cells

Names: cancer-associated surface antigen RCAS1; estrogen receptor-binding fragment-associated gene 9 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357690.2 → NP_001344619.1 receptor-binding cancer antigen expressed on SiSo cells

Status: VALIDATED

Source sequence(s)

AC128736

Consensus CDS

CCDS27457.1

UniProtKB/Swiss-Prot

Q0VET4, Q3TVG2, Q3TWY4, Q9D0V7, Q9QYD0

Related

ENSMUSP00000154361.2, ENSMUST00000227691.2

Conserved Domains (1) summary

pfam07946
Location:160 → 203

DUF1682; Protein of unknown function (DUF1682)
NM_001357691.2 → NP_001344620.1 receptor-binding cancer antigen expressed on SiSo cells

Status: VALIDATED

Source sequence(s)

AC128736

Consensus CDS

CCDS27457.1

UniProtKB/Swiss-Prot

Q0VET4, Q3TVG2, Q3TWY4, Q9D0V7, Q9QYD0

Related

ENSMUSP00000153791.2, ENSMUST00000226165.2

Conserved Domains (1) summary

pfam07946
Location:160 → 203

DUF1682; Protein of unknown function (DUF1682)
NM_001411929.1 → NP_001398858.1 receptor-binding cancer antigen expressed on SiSo cells

Status: VALIDATED

Source sequence(s)

AC128736

UniProtKB/Swiss-Prot

Q0VET4, Q3TVG2, Q3TWY4, Q9D0V7, Q9QYD0
NM_019480.6 → NP_062353.3 receptor-binding cancer antigen expressed on SiSo cells

See identical proteins and their annotated locations for NP_062353.3

Status: VALIDATED

Source sequence(s)

AC128736

Consensus CDS

CCDS27457.1

UniProtKB/Swiss-Prot

Q0VET4, Q3TVG2, Q3TWY4, Q9D0V7, Q9QYD0

Related

ENSMUSP00000022964.8, ENSMUST00000022964.9

Conserved Domains (1) summary

pfam07946
Location:160 → 203

DUF1682; Protein of unknown function (DUF1682)