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    Henmt1 HEN1 methyltransferase homolog 1 (Arabidopsis) [ Mus musculus (house mouse) ]

    Gene ID: 66715, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Henmt1provided by MGI
    Official Full Name
    HEN1 methyltransferase homolog 1 (Arabidopsis)provided by MGI
    Primary source
    MGI:MGI:1913965
    See related
    Ensembl:ENSMUSG00000045662 AllianceGenome:MGI:1913965
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hen1; mHEN1; 4921515J06Rik
    Summary
    Enables O-methyltransferase activity and RNA methyltransferase activity. Involved in RNA methylation and piRNA processing. Predicted to be located in P granule. Predicted to be active in cytoplasm and nucleus. Orthologous to human HENMT1 (HEN methyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 4.7) and CNS E18 (RPKM 0.3) See more
    Orthologs
    human all
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    Genomic context

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    See Henmt1 in Genome Data Viewer
    Location:
    3 F3; 3 47.99 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (108846770..108887201)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (108939454..108979885)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene fibronectin type III domain containing 7 Neighboring gene STARR-positive B cell enhancer ABC_E3460 Neighboring gene STARR-positive B cell enhancer ABC_E4576 Neighboring gene PRP38 pre-mRNA processing factor 38 (yeast) domain containing B Neighboring gene EEIG family member 2 Neighboring gene predicted gene 43221 Neighboring gene STARR-positive B cell enhancer mm9_chr3:108830639-108830939 Neighboring gene STARR-positive B cell enhancer mm9_chr3:108865935-108866236 Neighboring gene predicted gene, 36778

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. HENMT1 is involved in the maintenance of normal female fertility in the mouse. Hutt KJ, et al. Mol Hum Reprod, 2021 Nov 2. PMID 34590701
    2. Identification of substrates of the small RNA methyltransferase Hen1 in mouse spermatogonial stem cells and analysis of its methyl-transfer domain. Peng L, et al. J Biol Chem, 2018 Jun 29. PMID 29703750, Free PMC Article
    3. HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse. Lim SL, et al. PLoS Genet, 2015 Oct. PMID 26496356, Free PMC Article
    4. 2'-O-methyl modification in mouse piRNAs and its methylase. Kirino Y, et al. Nucleic Acids Symp Ser (Oxf), 2007. PMID 18029764
    5. The mouse homolog of HEN1 is a potential methylase for Piwi-interacting RNAs. Kirino Y, et al. RNA, 2007 Sep. PMID 17652135, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HENMT1 is involved in the maintenance of normal female fertility in the mouse.
      Title: HENMT1 is involved in the maintenance of normal female fertility in the mouse.
    2. methylation substrates in mouse spermatogonial stem cells and the substrate-recognition mechanism of mammalian Hen1
      Title: Identification of substrates of the small RNA methyltransferase Hen1 in mouse spermatogonial stem cells and analysis of its methyl-transfer domain.
    3. DNA damage and a catastrophic deregulation of the haploid germ cell gene expression. Collectively these results define a critical role for HENMT1 and piRNAs in the maintenance of TE repression in adult germ cells and setting the spermatogenic program.
      Title: HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117573

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables O-methyltransferase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables O-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables O-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small RNA 2'-O-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small RNA 2'-O-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in RNA methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in piRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in piRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in siRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in P granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    small RNA 2'-O-methyltransferase
    NP_001072114.1
    NP_079999.2
    XP_006501961.1
    XP_036019121.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001078646.1 → NP_001072114.1  small RNA 2'-O-methyltransferase

      See identical proteins and their annotated locations for NP_001072114.1

      Status: VALIDATED

      Source sequence(s)
      AK038994, BC099408
      Consensus CDS
      CCDS38602.1
      UniProtKB/Swiss-Prot
      A2VCS5, Q8C3K8, Q8CAE2
      Related
      ENSMUSP00000102196.3, ENSMUST00000106586.7
      Conserved Domains (2) summary
      cl02755
      Location:341 → 380
      LAM; LA motif RNA-binding domain
      cl17173
      Location:34 → 168
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. NM_025723.2 → NP_079999.2  small RNA 2'-O-methyltransferase

      See identical proteins and their annotated locations for NP_079999.2

      Status: VALIDATED

      Source sequence(s)
      BC099408, DV650789
      Consensus CDS
      CCDS38602.1
      UniProtKB/Swiss-Prot
      A2VCS5, Q8C3K8, Q8CAE2
      Related
      ENSMUSP00000054829.5, ENSMUST00000059946.11
      Conserved Domains (2) summary
      cl02755
      Location:341 → 380
      LAM; LA motif RNA-binding domain
      cl17173
      Location:34 → 168
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      108846770..108887201
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501898.3 → XP_006501961.1  small RNA 2'-O-methyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q8CAE2
      Conserved Domains (2) summary
      COG2227
      Location:83 → 134
      UbiG; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]
      pfam13649
      Location:9 → 103
      Methyltransf_25; Methyltransferase domain

    2. XM_036163228.1 → XP_036019121.1  small RNA 2'-O-methyltransferase isoform X1

      Related
      ENSMUSP00000143574.2, ENSMUST00000196533.2
      Conserved Domains (2) summary
      COG2227
      Location:83 → 134
      UbiG; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]
      pfam13649
      Location:9 → 103
      Methyltransf_25; Methyltransferase domain

    RNA

    1. XR_003954369.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CAE2.1 GenPept UniProtKB/Swiss-Prot:Q8CAE2

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