Ric1 RAB6A GEF complex partner 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ric1provided by MGI
Official Full Name: RAB6A GEF complex partner 1provided by MGI
Primary source: MGI:MGI:1924893
See related: Ensembl:ENSMUSG00000038658 AllianceGenome:MGI:1924893
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Kiaa1432; C030046E11Rik; C130057E09Rik
Summary: Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in several processes, including positive regulation of GTPase activity; regulation of extracellular matrix constituent secretion; and retrograde transport, endosome to Golgi. Predicted to be located in membrane. Predicted to be part of Ric1-Rgp1 guanyl-nucleotide exchange factor complex. Predicted to be active in Golgi membrane and cytosol. Orthologous to human RIC1 (RIC1 homolog, RAB6A GEF complex partner 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 7.7), subcutaneous fat pad adult (RPKM 5.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C1; 19 24.07 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (29499637..29583909)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (29522216..29605921)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB284739 (e-PCR)
- UniSTS:209453

NoName (e-PCR)
- UniSTS:237918

NoName (e-PCR)
- UniSTS:237920

NoName (e-PCR)
- UniSTS:488409

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cranial skeletal system development	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of extracellular matrix constituent secretion	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, endosome to Golgi	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of Ric1-Rgp1 guanyl-nucleotide exchange factor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Ric1-Rgp1 guanyl-nucleotide exchange factor complex	ISO Inferred from Sequence Orthology more info
part_of Ric1-Rgp1 guanyl-nucleotide exchange factor complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: guanine nucleotide exchange factor subunit RIC1

Names: RAB6A-GEF complex partner protein 1; protein RIC1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081319.1 → NP_001074788.1 guanine nucleotide exchange factor subunit RIC1

Status: PROVISIONAL

Source sequence(s)

AC093339, AC114578

Consensus CDS

CCDS37951.1

UniProtKB/Swiss-Prot

A4GZ02, Q3U0Q6, Q3UWK1, Q69ZJ7

UniProtKB/TrEMBL

E9QPA1

Related

ENSMUSP00000043437.7, ENSMUST00000043610.13

Conserved Domains (2) summary

pfam07064
Location:732 → 989

RIC1; RIC1

sd00039
Location:254 → 304

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

29499637..29583909

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250892.2 → XP_030106752.1 guanine nucleotide exchange factor subunit RIC1 isoform X2

UniProtKB/TrEMBL

F6S7U1

Conserved Domains (2) summary

sd00039
Location:167 → 217

7WD40; WD40 repeat [structural motif]

pfam07064
Location:645 → 902

RIC1
XM_036161563.1 → XP_036017456.1 guanine nucleotide exchange factor subunit RIC1 isoform X1

UniProtKB/Swiss-Prot

A4GZ02, Q3U0Q6, Q3UWK1, Q69ZJ7

Conserved Domains (2) summary

sd00039
Location:254 → 304

7WD40; WD40 repeat [structural motif]

pfam07064
Location:719 → 976

RIC1

RNA

XR_386464.5 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_177641.2: Suppressed sequence

Description

NM_177641.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.