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    LOC677877 major allergen I, polypeptide chain 1 [ Felis catus (domestic cat) ]

    Gene ID: 677877, updated on 16-Nov-2023

    Summary

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    Gene symbol
    LOC677877
    Gene description
    major allergen I, polypeptide chain 1
    See related
    EnsemblRapid:ENSFCTG00005012137
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Felis catus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
    Also known as
    CH1
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    Genomic context

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    See LOC677877 in Genome Data Viewer
    Location:
    chromosome: E2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) E2 NC_058382.1 (18605598..18607565)

    Chromosome E2 - NC_058382.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC123382206 Neighboring gene zinc finger protein 181 Neighboring gene major allergen I, polypeptide chain 2 Neighboring gene beclin-1-like Neighboring gene WT1 interacting protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_058382.1 Chromosome E2 Reference F.catus_Fca126_mat1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Calcium Goes Meow: Effects of Ions and Glycosylation on Fel d 1, the Major Cat Allergen. Ligabue-Braun R, et al. PLoS One, 2015. PMID 26134118, Free PMC Article
    2. Distribution of core fragments from the major cat allergen Fel d 1 is maintained among the main anatomical sites of production. Bienboire-Frosini C, et al. Int Arch Allergy Immunol, 2010. PMID 20145408
    3. Crystallization and preliminary crystallographic data of a Fel d 1 (1+2) construct corresponding to the major allergen from cat. Kaiser L, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2005 Feb 1. PMID 16511003, Free PMC Article
    4. The crystal structure of the major cat allergen Fel d 1, a member of the secretoglobin family. Kaiser L, et al. J Biol Chem, 2003 Sep 26. PMID 12851385
    5. Cat allergen 1: Biochemical, antigenic, and allergenic properties. Leitermann K, et al. J Allergy Clin Immunol, 1984 Aug. PMID 6747135

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cat Fel d 1 is an ABP-like molecule in which monomeric chains 1 and 2 are the equivalent of the ABPA and ABPBG monomers, respectively. These findings suggest that the biological and molecular function of Fel d 1 is similar to that of ABP in chemical communication, possibly via pheromone and/or steroid binding.
      Title: Another cat and mouse game: Deciphering the evolution of the SCGB superfamily and exploring the molecular similarity of major cat allergen Fel d 1 and mouse ABP using computational approaches.
    2. Conformational effects brought upon by glycosylation were identified, potentially involved in cavity volume regulation. Only the central Ca2+ ion remains coordinated to Fel d 1 in biological solutions, impairing its role in modulating phospholipase A2.
      Title: The Calcium Goes Meow: Effects of Ions and Glycosylation on Fel d 1, the Major Cat Allergen.
    3. Truncated dimers of Fel d 1 were identified, probably resulting from proteolytic degradation of both chains and present in all cats. Core fragments are largely distributed among anatomical sites of production and especially well represented in anal sac.
      Title: Distribution of core fragments from the major cat allergen Fel d 1 is maintained among the main anatomical sites of production.
    4. Crystals of Fel d 1 (1+2) were obtained using the hanging-drop vapour-diffusion method.
      Title: Crystallization and preliminary crystallographic data of a Fel d 1 (1+2) construct corresponding to the major allergen from cat.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    major allergen I polypeptide chain 1
    Names
    AG4
    allergen Cat-1
    allergen FdI
    allergen Fel d I-A
    allergen Fel dI
    fel d I chain 1 precursor with leader A
    fel d I chain 1 precursor with leader B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048153.1 → NP_001041618.1  major allergen I polypeptide chain 1 precursor

      See identical proteins and their annotated locations for NP_001041618.1

      Status: PROVISIONAL

      Source sequence(s)
      M74953
      UniProtKB/Swiss-Prot
      P30438
      Related
      ENSFCTP00005023376.1, ENSFCTT00005034347.1
      Conserved Domains (1) summary
      cl11457
      Location:19 → 88
      Secretoglobin; Secretoglobins are relatively small, secreted, disulphide-bridged dimeric proteins with encoding genes sharing substantial sequence similarity. Their family subunits may be grouped into five subfamilies, A-E. Uteroglobin (subfamily A), which is identical ...

    RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference F.catus_Fca126_mat1.0 Primary Assembly

    Genomic

    1. NC_058382.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

      Range
      18605598..18607565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_045045418.1 → XP_044901353.1  major allergen I polypeptide chain 1 isoform X1

      UniProtKB/Swiss-Prot
      P30438, P30439
      Conserved Domains (1) summary
      smart00096
      Location:23 → 92
      UTG; Uteroglobin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30438.2 GenPept UniProtKB/Swiss-Prot:P30438

    Gene LinkOut

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