Fbxo11 F-box protein 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fbxo11provided by MGI
Official Full Name: F-box protein 11provided by MGI
Primary source: MGI:MGI:2147134
See related: Ensembl:ENSMUSG00000005371 AllianceGenome:MGI:2147134
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Jf
Summary: Enables ubiquitin-protein transferase activity. Involved in sensory perception of sound. Predicted to be located in cytoplasm; nucleolus; and nucleoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and respiratory system. Used to study otitis media. Human ortholog(s) of this gene implicated in breast carcinoma and lung non-small cell carcinoma. Orthologous to human FBXO11 (F-box protein 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E14 (RPKM 23.5), whole brain E14.5 (RPKM 20.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 E4; 17 57.87 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (88298287..88373473, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (87990859..88066045, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FBXO11 constitutes a major negative regulator of MHC class II through ubiquitin-dependent proteasomal degradation of CIITA.
Title: FBXO11 constitutes a major negative regulator of MHC class II through ubiquitin-dependent proteasomal degradation of CIITA.
FBXO11 regulates bone development.
Title: FBXO11 regulates bone development.
Frequent mutations of FBXO11 highlight BCL6 as a therapeutic target in Burkitt lymphoma.
Title: Frequent mutations of FBXO11 highlight BCL6 as a therapeutic target in Burkitt lymphoma.
a bulla cavitation defect initiates the pathogenesis of otitis media in the established mouse model Jeff (Fbxo11(Jf/+) ).
Title: Chronic otitis media is initiated by a bulla cavitation defect in the FBXO11 mouse model.
Through a loss-of-function screen authors found that a member of the E3 ubiquitin ligase complexes, FBXO11, specifically fuels tumor formation of a non-EMT-like clone by restraining the p53/p21 pathway. Interestingly, in the related EMT-like clone, FBXO11 operates through the BCL2 pathway with little or no impact on tumorigenesis.
Title: Aggressiveness of non-EMT breast cancer cells relies on FBXO11 activity.
FBXO11 inactivation was associated with the development of lymphoproliferative disorders in mice.
Title: FBXO11 inactivation leads to abnormal germinal-center formation and lymphoproliferative disease.
FBXO11 regulates the TGF-beta pathway in the embryonic lung via cross-talk with p53.
Title: Interactions between the otitis media gene, Fbxo11, and p53 in the mouse embryonic lung.
Relationship between dilation of endoplasmic reticulum and decreased levels of the FBXO11 gene in vitiligo melanocytes.
Title: VIT1/FBXO11 knockdown induces morphological alterations and apoptosis in B10BR mouse melanocytes.
FBXO11 is one of the first molecules to be identified, contributing to the genetic aetiology of otitis media
Title: A mutation in the F-box gene, Fbxo11, causes otitis media in the Jeff mouse.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH140511 (e-PCR)
- UniSTS:222581

NoName (e-PCR)
- UniSTS:237726

AU044881 (e-PCR)
- UniSTS:160706

RH126790 (e-PCR)
- UniSTS:209350

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-arginine N-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-arginine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-protein transferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial to mesenchymal transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein modification process	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: F-box only protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081034.3 → NP_001074503.1 F-box only protein 11 isoform 1

See identical proteins and their annotated locations for NP_001074503.1

Status: VALIDATED

Source sequence(s)

AC087233, AC154673, AI853268, BC055343, BY127063, CA557033, CA749247, CF169182, CF172333, CN533292, CN666984

Consensus CDS

CCDS37717.1

UniProtKB/Swiss-Prot

A1A595, E9QP06, Q08EB9, Q08EC0, Q7TPD1, Q80UP0

Related

ENSMUSP00000005504.9, ENSMUST00000005504.15

Conserved Domains (3) summary

pfam12937
Location:160 → 203

F-box-like; F-box-like

pfam13229
Location:667 → 812

Beta_helix; Right handed beta helix region

cl19744
Location:853 → 894

zf-UBR; Putative zinc finger in N-recognin (UBR box)
NM_001348248.1 → NP_001335177.1 F-box only protein 11 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AC087233, AC154673, BC055343, BY127063, CA557033, CA749247, CF169182, CF172333, CN533292, CN666984

UniProtKB/Swiss-Prot

Q7TPD1

Conserved Domains (3) summary

pfam12937
Location:73 → 116

F-box-like

pfam13229
Location:580 → 739

Beta_helix; Right handed beta helix region

cl19744
Location:766 → 807

zf-UBR; Putative zinc finger in N-recognin (UBR box)
NM_001379303.1 → NP_001366232.1 F-box only protein 11 isoform 3

Status: VALIDATED

Source sequence(s)

AC087233, AC154673

Conserved Domains (3) summary

pfam12937
Location:159 → 202

F-box-like

pfam13229
Location:666 → 825

Beta_helix; Right handed beta helix region

cl19744
Location:852 → 893

zf-UBR; Putative zinc finger in N-recognin (UBR box)
NM_001379304.1 → NP_001366233.1 F-box only protein 11 isoform 2

Status: VALIDATED

Source sequence(s)

AC087233, AC154673

Conserved Domains (3) summary

pfam12937
Location:73 → 116

F-box-like

pfam13229
Location:580 → 739

Beta_helix; Right handed beta helix region

cl19744
Location:766 → 807

zf-UBR; Putative zinc finger in N-recognin (UBR box)
NM_001379305.1 → NP_001366234.1 F-box only protein 11 isoform 4

Status: VALIDATED

Source sequence(s)

AC087233, AC154673

Related

ENSMUSP00000121206.3, ENSMUST00000130379.9

Conserved Domains (3) summary

pfam12937
Location:72 → 115

F-box-like

pfam13229
Location:579 → 738

Beta_helix; Right handed beta helix region

cl19744
Location:765 → 806

zf-UBR; Putative zinc finger in N-recognin (UBR box)
NM_001414440.1 → NP_001401369.1 F-box only protein 11 isoform 4

Status: VALIDATED

Source sequence(s)

AC087233, AC154673