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    dok1a docking protein 1a [ Danio rerio (zebrafish) ]

    Gene ID: 559168, updated on 4-Jan-2025

    Summary

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    Official Symbol
    dok1aprovided by ZNC
    Official Full Name
    docking protein 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080721-2
    See related
    Ensembl:ENSDARG00000078108 AllianceGenome:ZFIN:ZDB-GENE-080721-2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to be involved in Ras protein signal transduction and cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be active in cytoplasm. Orthologous to human DOK1 (docking protein 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See dok1a in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (41478345..41485335)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (40775454..40782191)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene transfer RNA glutamic acid (anticodon CUC) Neighboring gene poly(A) binding protein interacting protein 2B Neighboring gene si:ch211-89o9.6 Neighboring gene transfer RNA lysine (anticodon CUU)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Comparative genomics of Lbx loci reveals conservation of identical Lbx ohnologs in bony vertebrates. Wotton KR, et al. BMC Evol Biol, 2008 Jun 9. PMID 18541024, Free PMC Article
    2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    docking protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      41478345..41485335
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_682484.9 → XP_687576.4  docking protein 2

      UniProtKB/TrEMBL
      A0A8N7USX8, F6P620
      Related
      ENSDARP00000113679.2, ENSDART00000134626.3
      Conserved Domains (2) summary
      pfam00169
      Location:6 → 114
      PH; PH domain
      cl17171
      Location:143 → 241
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

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