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    FGA fibrinogen alpha chain [ Bos indicus (zebu cattle) ]

    Gene ID: 109571095, updated on 14-Mar-2024

    Summary

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    Gene symbol
    FGA
    Gene description
    fibrinogen alpha chain
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos indicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See FGA in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    100 current Bos_indicus_1.0 (GCF_000247795.1) 17 NC_032666.1 (3086899..3095040)

    Chromosome 17 - NC_032666.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC109571495 Neighboring gene fibrinogen gamma chain Neighboring gene fibrinogen beta chain Neighboring gene pleiotropic regulator 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_032666.1 Chromosome 17 Reference Bos_indicus_1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in blood coagulation, common pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in fibrinolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of endothelial cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in platelet activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in platelet aggregation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of heterotypic cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of peptide hormone secretion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein polymerization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of fibrinogen complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fibrinogen alpha chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Bos indicus Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Bos_indicus_1.0 Primary Assembly

    Genomic

    1. NC_032666.1 Reference Bos_indicus_1.0 Primary Assembly

      Range
      3086899..3095040
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_019977302.1 → XP_019832861.1  fibrinogen alpha chain

      UniProtKB/TrEMBL
      A0A6P5D3L3
      Conserved Domains (4) summary
      cd00087
      Location:627 → 860
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      pfam06346
      Location:301 → 402
      Drf_FH1; Formin Homology Region 1
      pfam08702
      Location:79 → 218
      Fib_alpha; Fibrinogen alpha/beta chain family
      pfam12160
      Location:466 → 531
      Fibrinogen_aC; Fibrinogen alpha C domain
    Nucleotide Protein
    Heading Accession and Version

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