tnfsf10l TNF superfamily member 10, like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tnfsf10lprovided by ZNC
Official Full Name: TNF superfamily member 10, likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-010801-1
See related: Ensembl:ENSDARG00000004196 AllianceGenome:ZFIN:ZDB-GENE-010801-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dl1a; wu:fc12f06
Summary: Predicted to enable cytokine activity. Acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in several structures, including adaxial cell; central nervous system; endoderm; germ ring; and head. Human ortholog(s) of this gene implicated in arteriosclerosis and small cell carcinoma. Orthologous to human TNFSF10 (TNF superfamily member 10). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (22914861..22956907, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (22643698..22685821, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc12f06.x1 (e-PCR)
- UniSTS:203794

AI626285 (e-PCR)
- UniSTS:206141

fa14c03.s1 (e-PCR)
- UniSTS:202378

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables tumor necrosis factor receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immune response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: TNF superfamily member 10, like

Names: TNFSF10-2; TRAIL-like; death ligand 1a; tumor necrosis factor (ligand) superfamily, member 10 like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131843.2 → NP_571918.2 TNF superfamily member 10, like

See identical proteins and their annotated locations for NP_571918.2

Status: PROVISIONAL

Source sequence(s)

BC044336

UniProtKB/TrEMBL

Q7ZYX9

Related

ENSDARP00000092221.4, ENSDART00000101447.7

Conserved Domains (1) summary

pfam00229
Location:189 → 315

TNF; TNF(Tumour Necrosis Factor) family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

22914861..22956907 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005172247.5 → XP_005172304.1 TNF superfamily member 10, like isoform X1

UniProtKB/TrEMBL

A0A8M2BK35

Conserved Domains (1) summary

pfam00229
Location:188 → 314

TNF; TNF(Tumour Necrosis Factor) family