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    Rab3-GEF Rab3 GDP-GTP exchange factor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32442, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Rab3-GEFprovided by FlyBase
    Official Full Name
    Rab3 GDP-GTP exchange factorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030613
    Locus tag
    Dmel_CG5627
    See related
    AllianceGenome:FB:FBgn0030613
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey246; BEST:GH21304; CG5627; Dmel\CG5627; rab3-gef; rab3-GEF
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Involved in cytoskeletal matrix organization at active zone. Located in neuromuscular junction of somatic muscle; neuronal cell body; and terminal bouton. Is expressed in adult head; larval brain; and larval ventral nerve cord. Orthologous to human MADD (MAP kinase activating death domain). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rab3-GEF in Genome Data Viewer
    Location:
    13A10-13A12; 1-49 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15089682..15113762)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14983715..15007777)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Dihydrolipoamide branched chain transacylase E2 Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 4s3 Neighboring gene drop dead Neighboring gene Ribosomal protein L37-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. uDENN, DENN, and dDENN: indissociable domains in Rab and MAP kinases signaling pathways. Levivier E, et al. Biochem Biophys Res Commun, 2001 Sep 28. PMID 11563850
    2. Rab3-GEF Controls Active Zone Development at the Drosophila Neuromuscular Junction. Bae H, et al. eNeuro, 2016 Mar-Apr. PMID 27022630, Free PMC Article
    3. Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology. Dourlen P, et al. Mol Psychiatry, 2017 Jun. PMID 27113998, Free PMC Article
    4. Using High-Throughput Animal or Cell-Based Models to Functionally Characterize GWAS Signals. Dourlen P, et al. Curr Genet Med Rep, 2018. PMID 30147999, Free PMC Article
    5. Tip60's Novel RNA-Binding Function Modulates Alternative Splicing of Pre-mRNA Targets Implicated in Alzheimer's Disease. Bhatnagar A, et al. J Neurosci, 2023 Mar 29. PMID 36849418, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeletal matrix organization at active zone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neurotransmitter secretion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of Rab protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of Rab protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of extrinsic apoptotic signaling pathway via death domain receptors ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in neuromuscular junction of somatic muscle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in terminal bouton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rab3 GDP-GTP exchange factor
    Names
    CG5627-PC
    CG5627-PD
    CG5627-PE
    CG5627-PF
    CG5627-PG
    CG5627-PH
    CG5627-PI
    CG5627-PJ
    CG5627-PK
    CG5627-PL
    Rab3-GEF-PC
    Rab3-GEF-PD
    Rab3-GEF-PE
    Rab3-GEF-PF
    Rab3-GEF-PG
    Rab3-GEF-PH
    Rab3-GEF-PI
    Rab3-GEF-PJ
    Rab3-GEF-PK
    Rab3-GEF-PL
    rab3-GEF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15089682..15113762
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001347810.1 → NP_001334680.1  Rab3 GDP-GTP exchange factor, isoform K [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1Z1CSK9, A0A3G1DKV1

    2. NM_001347809.1 → NP_001334679.1  Rab3 GDP-GTP exchange factor, isoform J [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1Z1CGX2, A0A3G1DKV1

    3. NM_001103513.3 → NP_001096983.2  Rab3 GDP-GTP exchange factor, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096983.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3G1DKV1, A8JUX2
      Conserved Domains (3) summary
      smart00801
      Location:610 → 678
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:268 → 494
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:10 → 111
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    4. NM_001272631.1 → NP_001259560.1  Rab3 GDP-GTP exchange factor, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259560.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3G1DKV1, M9PEM6
      Conserved Domains (3) summary
      smart00801
      Location:613 → 681
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:260 → 486
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:10 → 111
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    5. NM_001316635.1 → NP_001303564.1  Rab3 GDP-GTP exchange factor, isoform I [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0S0X7U5, A0A3G1DKV1
      Conserved Domains (3) summary
      smart00801
      Location:613 → 681
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:260 → 486
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:10 → 111
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    6. NM_001272630.1 → NP_001259559.1  Rab3 GDP-GTP exchange factor, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259559.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3G1DKV1, M9PJN3
      Conserved Domains (3) summary
      smart00801
      Location:602 → 670
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:260 → 486
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:10 → 111
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    7. NM_132773.3 → NP_573001.2  Rab3 GDP-GTP exchange factor, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573001.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MSD8, Q9VXY2
      UniProtKB/TrEMBL
      A0A3G1DKV1
      Conserved Domains (3) summary
      smart00801
      Location:602 → 670
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:260 → 486
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:10 → 111
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    8. NM_001258746.2 → NP_001245675.1  Rab3 GDP-GTP exchange factor, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245675.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3G1DKV1, M9NGF2
      Conserved Domains (3) summary
      smart00801
      Location:599 → 667
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:257 → 483
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:10 → 111
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    9. NM_001347811.1 → NP_001334681.1  Rab3 GDP-GTP exchange factor, isoform L [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1Z1CGY3, A0A3G1DKV1

    10. NM_001258747.1 → NP_001245676.1  Rab3 GDP-GTP exchange factor, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245676.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A3G1DKV1, M9NEH3
      Conserved Domains (3) summary
      smart00801
      Location:602 → 670
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:260 → 486
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:10 → 111
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0S0X7U5 A0A0S0X7U5
    A0A1Z1CGX2 A0A1Z1CGX2
    A0A1Z1CGY3 A0A1Z1CGY3
    A0A1Z1CSK9 A0A1Z1CSK9
    A8JUX2 A8JUX2
    M9NEH3 M9NEH3
    M9NGF2 M9NGF2
    M9PEM6 M9PEM6
    M9PJN3 M9PJN3
    Q9VXY2.2 Q9VXY2

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