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    Akap1 A kinase anchor protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 11640, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Akap1provided by MGI
    Official Full Name
    A kinase anchor protein 1provided by MGI
    Primary source
    MGI:MGI:104729
    See related
    Ensembl:ENSMUSG00000018428 AllianceGenome:MGI:104729
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Akap; AKAP84; DAKAP1; AKAP121; S-AKAP84
    Summary
    Predicted to enable several functions, including enzyme binding activity; protein kinase A regulatory subunit binding activity; and tubulin binding activity. Involved in apoptotic process. Located in mitochondrion. Is expressed in several structures, including brown fat; central nervous system; genitourinary system; gut; and sensory organ. Orthologous to human AKAP1 (A-kinase anchoring protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 171.5), heart adult (RPKM 26.9) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Akap1 in Genome Data Viewer
    Location:
    11 C; 11 54.34 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (88721618..88755426, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (88830792..88864596, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene musashi RNA-binding protein 2 Neighboring gene RIKEN cDNA 0610039H22 gene Neighboring gene STARR-seq mESC enhancer starr_30351 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:88488860-88488969 Neighboring gene STARR-seq mESC enhancer starr_30353 Neighboring gene STARR-seq mESC enhancer starr_30356 Neighboring gene STARR-seq mESC enhancer starr_30358 Neighboring gene RIKEN cDNA C030037D09 gene Neighboring gene STARR-seq mESC enhancer starr_30361 Neighboring gene STARR-positive B cell enhancer ABC_E5262 Neighboring gene STARR-seq mESC enhancer starr_30363 Neighboring gene RIKEN cDNA 4930556N13 gene Neighboring gene STARR-positive B cell enhancer ABC_E7042 Neighboring gene STARR-seq mESC enhancer starr_30370 Neighboring gene serine carboxypeptidase 1, opposite strand Neighboring gene predicted gene, 23507 Neighboring gene serine carboxypeptidase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cardiac ischemia-reperfusion injury induces ROS-dependent loss of PKA regulatory subunit RIα. Haushalter KJ, et al. Am J Physiol Heart Circ Physiol, 2019 Dec 1. PMID 31674811, Free PMC Article
    2. Assembly of AKAP82, a protein kinase A anchor protein, into the fibrous sheath of mouse sperm. Johnson LR, et al. Dev Biol, 1997 Dec 15. PMID 9441672
    3. Regulation, localization, and anchoring of protein kinase A subunits during mouse sperm capacitation. Visconti PE, et al. Dev Biol, 1997 Dec 15. PMID 9441673
    4. A 15-residue bifunctional element in D-AKAP1 is required for both endoplasmic reticulum and mitochondrial targeting. Ma Y, et al. J Biol Chem, 2002 Jul 26. PMID 11994283
    5. Akap1 genetic deletion increases the severity of hyperoxia-induced acute lung injury in mice. Narala VR, et al. Am J Physiol Lung Cell Mol Physiol, 2018 May 1. PMID 29388469, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AKAP1 in Renal Patients with AHF to Reduce Ferroptosis of Cardiomyocyte.
      Title: AKAP1 in Renal Patients with AHF to Reduce Ferroptosis of Cardiomyocyte.
    2. Akap1 deficiency exacerbates diabetic cardiomyopathy in mice by NDUFS1-mediated mitochondrial dysfunction and apoptosis.
      Title: Akap1 deficiency exacerbates diabetic cardiomyopathy in mice by NDUFS1-mediated mitochondrial dysfunction and apoptosis.
    3. Loss of AKAP1 triggers Drp1 dephosphorylation-mediated mitochondrial fission and loss in retinal ganglion cells.
      Title: Loss of AKAP1 triggers Drp1 dephosphorylation-mediated mitochondrial fission and loss in retinal ganglion cells.
    4. AKAP121/PKA confers neuroprotection in an in vitro model of oxidative stress induced by exposure to excess glutamate.
      Title: Neuroprotective Mitochondrial Remodeling by AKAP121/PKA Protects HT22 Cell from Glutamate-Induced Oxidative Stress.
    5. genetic disinhibition of Drp1 via knock-out of the mitochondrial protein kinase A (PKA) scaffold AKAP1 exacerbates stroke injury in mice. Mechanistically, we show that electron transport deficiency, increased superoxide production, and Ca(2+) overload result from genetic disinhibition of Drp1.
      Title: AKAP1 Protects from Cerebral Ischemic Stroke by Inhibiting Drp1-Dependent Mitochondrial Fission.
    6. Ring finger protein20 regulates hepatic lipid metabolism through protein kinase A-dependent sterol regulatory element binding protein1c degradation.
      Title: Ring finger protein20 regulates hepatic lipid metabolism through protein kinase A-dependent sterol regulatory element binding protein1c degradation.
    7. Loss of AKAP1 expression is associated with acute lung injury.
      Title: Akap1 genetic deletion increases the severity of hyperoxia-induced acute lung injury in mice.
    8. these results identify a novel AKAP-mediated biochemical mechanism that increases TRPA1 sensitivity in peripheral sensory neurons, and likely contributes to persistent mechanical hypersensitivity.
      Title: A-Kinase Anchoring Protein 79/150 Scaffolds Transient Receptor Potential A 1 Phosphorylation and Sensitization by Metabotropic Glutamate Receptor Activation.
    9. AKAP1 is a transcriptional target of Myc, and it supports mTOR pathway and the growth of cancer cells.
      Title: Mitochondrial AKAP1 supports mTOR pathway and tumor growth.
    10. Genetic ablation of AKAP7 specifically from dentate granule cells results in disruption of mossy fiber-CA3 pyramidal neuron long-term potentiation directly initiated by cAMP, and the AKAP7 mutant mice are selectively deficient in pattern separation behaviors. The results suggest that the AKAP7/PKA complex in the mossy fiber projections plays an essential role in synaptic plasticity and contextual memory formation.
      Title: Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables beta-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase A regulatory subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase A regulatory subunit binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase A regulatory subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase 2B binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in antiviral innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cardiac muscle hypertrophy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial crista ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic specialization, intracellular component ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    A-kinase anchor protein 1, mitochondrial
    Names
    A kinase (PRKA) anchor protein 1
    D-AKAP-1
    PRKA1
    S-AKAP
    a kinase anchor protein 1, mitochondrial
    dual specificity A-kinase-anchoring protein 1
    protein kinase A-anchoring protein 1
    spermatid A-kinase anchor protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042541.1 → NP_001036006.1  A-kinase anchor protein 1, mitochondrial

      See identical proteins and their annotated locations for NP_001036006.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR exon, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK020371, AK132749, AL596180, CJ167452
      Consensus CDS
      CCDS25229.1
      UniProtKB/Swiss-Prot
      B1AR25, O08714, O08715, P97488
      Related
      ENSMUSP00000018572.5, ENSMUST00000018572.11
      Conserved Domains (3) summary
      smart00333
      Location:710 → 768
      TUDOR; Tudor domain
      cd00105
      Location:565 → 625
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00567
      Location:658 → 780
      TUDOR; Tudor domain

    2. NM_009648.2 → NP_033778.2  A-kinase anchor protein 1, mitochondrial

      See identical proteins and their annotated locations for NP_033778.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) and variant 2 encode the same protein.
      Source sequence(s)
      AK020371, AK132749, AL596180
      Consensus CDS
      CCDS25229.1
      UniProtKB/Swiss-Prot
      B1AR25, O08714, O08715, P97488
      Related
      ENSMUSP00000103536.2, ENSMUST00000107903.8
      Conserved Domains (3) summary
      smart00333
      Location:710 → 768
      TUDOR; Tudor domain
      cd00105
      Location:565 → 625
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00567
      Location:658 → 780
      TUDOR; Tudor domain

    RNA

    1. NR_104310.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an additional exon in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK132749, AK186415, AW985969, BC065135
      Related
      ENSMUST00000143720.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      88721618..88755426 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245481.2 → XP_030101341.1  A-kinase anchor protein 1, mitochondrial isoform X1

    RNA

    1. XR_388330.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08715.4 GenPept UniProtKB/Swiss-Prot:O08715

    Gene LinkOut

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