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    her8a hairy-related 8a [ Danio rerio (zebrafish) ]

    Gene ID: 323656, updated on 9-Dec-2024

    Summary

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    Official Symbol
    her8aprovided by ZNC
    Official Full Name
    hairy-related 8aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2376
    See related
    Ensembl:ENSDARG00000016363 AllianceGenome:ZFIN:ZDB-GENE-030131-2376
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    her8b; her-8a; her-8b; zgc:85712; wu:fb75f05; wu:fc06c04
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within glial cell differentiation; negative regulation of neurogenesis; and neuron differentiation. Is active in chromatin. Is expressed in several structures, including anterior neural keel; anterior neural rod; central nervous system; neural tube; and posterior neural keel. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See her8a in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (26429941..26436482, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (26160554..26165379, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex subunit 14 Neighboring gene galactose-3-O-sulfotransferase 4 Neighboring gene si:dkey-3k24.8 Neighboring gene transmembrane 4 L six family member 21b Neighboring gene metallo-beta-lactamase domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Deltex1 is inhibited by the Notch-Hairy/E(Spl) signaling pathway and induces neuronal and glial differentiation. Cheng YC, et al. Neural Dev, 2015 Dec 30. PMID 26714454, Free PMC Article
    2. Proteasome subunit PSMC3 variants cause neurosensory syndrome combining deafness and cataract due to proteotoxic stress. Kröll-Hermi A, et al. EMBO Mol Med, 2020 Jul 7. PMID 32500975, Free PMC Article
    3. Akt1 mediates neuronal differentiation in zebrafish via a reciprocal interaction with notch signaling. Cheng YC, et al. PLoS One, 2013. PMID 23342113, Free PMC Article
    4. Comparative analysis of somitogenesis related genes of the hairy/Enhancer of split class in Fugu and zebrafish. Gajewski M, et al. BMC Genomics, 2002 Aug 5. PMID 12160468, Free PMC Article
    5. Transcriptomic characterization of cold acclimation in larval zebrafish. Long Y, et al. BMC Genomics, 2013 Sep 11. PMID 24024969, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that Her8a is a negative regulator of neurogenesis and plays an essential role in generating progenitor pools within rhombomeres 2 and 4--a role resembling that of Her3.
      Title: The Enhancer of split transcription factor Her8a is a novel dimerisation partner for Her3 that controls anterior hindbrain neurogenesis in zebrafish.
    2. her8a is positively regulated by Su(H)-dependent Notch signaling as revealed by a Notch-defective mutant and injection of variants of the Notch intracellular regulator, Su(H).
      Title: Zebrafish Her8a is activated by Su(H)-dependent Notch signaling and is essential for the inhibition of neurogenesis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterior/posterior pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within gliogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    hairy-related 8a
    Names
    hairy-related 8b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199624.3 → NP_955918.3  hairy-related 8a

      Status: VALIDATED

      Source sequence(s)
      CR848737, EH587922
      UniProtKB/TrEMBL
      A0A8M1PE83, F1QI81, F1R6H0
      Related
      ENSDARP00000111735.3, ENSDART00000123395.4
      Conserved Domains (2) summary
      cd00083
      Location:17 → 75
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam07527
      Location:95 → 133
      Hairy_orange; Hairy Orange

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      26429941..26436482 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005172256.5 → XP_005172313.1  hairy-related 8a isoform X1

      UniProtKB/TrEMBL
      A0A8M2BJI1
      Conserved Domains (2) summary
      cd00083
      Location:17 → 75
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam07527
      Location:91 → 129
      Hairy_orange; Hairy Orange

    RNA

    1. XR_011016139.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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