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    LINC01018 long intergenic non-protein coding RNA 1018 [ Homo sapiens (human) ]

    Gene ID: 255167, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LINC01018provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 1018provided by HGNC
    Primary source
    HGNC:HGNC:27394
    See related
    Ensembl:ENSG00000250056 MIM:616385; AllianceGenome:HGNC:27394
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SRHC
    Expression
    Biased expression in liver (RPKM 18.7), ovary (RPKM 7.1) and 2 other tissues See more
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    Genomic context

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    See LINC01018 in Genome Data Viewer
    Location:
    5p15.31
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (6582136..6588500)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (6512544..6518915)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (6582249..6588613)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:6408294-6409493 Neighboring gene uncharacterized LOC124900933 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15896 Neighboring gene uncharacterized LOC105374639 Neighboring gene ubiquitin conjugating enzyme E2 QL1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22331 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22333 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22334 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15898 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:6583428-6583589 Neighboring gene NOP2/Sun RNA methyltransferase 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:6633253-6633764 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:6633765-6634276 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:6648951-6649644 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:6649645-6650336 Neighboring gene steroid 5 alpha-reductase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22335

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Long non-coding RNA LINC01018 inhibits human glioma cell proliferation and metastasis by directly targeting miRNA-182-5p. Su H, et al. J Neurooncol, 2022 Oct. PMID 36094613
    2. In vivo functional analysis of non-conserved human lncRNAs associated with cardiometabolic traits. Ruan X, et al. Nat Commun, 2020 Jan 2. PMID 31896749, Free PMC Article
    3. Epigenetically silenced long noncoding-SRHC promotes proliferation of hepatocellular carcinoma. Zheng H, et al. J Cancer Res Clin Oncol, 2015 Jul. PMID 25512078
    4. LINC01018 and SMIM25 sponged miR-182-5p in endometriosis revealed by the ceRNA network construction. Jiang L, et al. Int J Immunopathol Pharmacol, 2020 Jan-Dec. PMID 33237828, Free PMC Article
    5. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long non-coding RNA LINC01018 inhibits human glioma cell proliferation and metastasis by directly targeting miRNA-182-5p.
      Title: Long non-coding RNA LINC01018 inhibits human glioma cell proliferation and metastasis by directly targeting miRNA-182-5p.
    2. LINC01018 and SMIM25 sponged miR-182-5p in endometriosis revealed by the ceRNA network construction.
      Title: LINC01018 and SMIM25 sponged miR-182-5p in endometriosis revealed by the ceRNA network construction.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • CTD-2195M18.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_024423.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains alternate 5' exons, compared to variant 1.
      Source sequence(s)
      AK125283, BC043253, DA240476, DB572334
      Related
      ENST00000505626.7

    2. NR_024424.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AK125283, BC043253, BC106918, BI602592, DB572334
      Related
      ENST00000664093.3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      6582136..6588500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      6512544..6518915
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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