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    CDC25 Rhodanese/Cell cycle control phosphatase superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831832, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CDC25
    Official Full Name
    Rhodanese/Cell cycle control phosphatase superfamily protein
    Primary source
    TAIR:AT5G03455
    Locus tag
    AT5G03455
    See related
    Araport:AT5G03455
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ACR2; ARATH;CDC25; ARSENATE REDUCTASE; ARSENATE REDUCTASE 2; AtACR2
    Summary
    Encodes a homolog of yeast cell cycle regulator CDC25. It has a sole catalytic domain and devoid of the N-terminal regulatory region found in the human CDC25 and is capable of reducing the mitotic cell length of transformed fission yeast. Non-plant CDC25 proteins have been shown to do this. However, the gene is more or less constant, regardless of whether the tissue examined contained proliferative cells. Also described as having arsenate reductase activity involved in arsenate resistance.
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    Genomic context

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    See CDC25 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    3
    Sequence:
    Chromosome: 5; NC_003076.8 (862556..864176)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene tRNA-Phe Neighboring gene uncharacterized protein Neighboring gene Protein phosphatase 2A regulatory B subunit family protein Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phytoremediation of arsenic from the contaminated soil using transgenic tobacco plants expressing ACR2 gene of Arabidopsis thaliana. Nahar N, et al. J Plant Physiol, 2017 Nov. PMID 28818758
    2. In silico and in vivo studies of an Arabidopsis thaliana gene, ACR2, putatively involved in arsenic accumulation in plants. Nahar N, et al. J Mol Model, 2012 Sep. PMID 22562211
    3. Arabidopsis T-DNA insertional lines for CDC25 are hypersensitive to hydroxyurea but not to zeocin or salt stress. Spadafora ND, et al. Ann Bot, 2011 May. PMID 20647223, Free PMC Article
    4. Hyperaccumulation of arsenic in the shoots of Arabidopsis silenced for arsenate reductase (ACR2). Dhankher OP, et al. Proc Natl Acad Sci U S A, 2006 Apr 4. PMID 16567632, Free PMC Article
    5. The Arabidopsis CDC25 induces a short cell length when overexpressed in fission yeast: evidence for cell cycle function. Sorrell DA, et al. New Phytol, 2005 Feb. PMID 15720653

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis thaliana AtACR2 gene is a potential candidate for genetic engineering of plants to develop new crop cultivars that can be grown on arsenic contaminated fields to reduce arsenic content of the soil and can become a source of food containing no arsenic or exhibiting substantially reduced amount of this metalloid.
      Title: Phytoremediation of arsenic from the contaminated soil using transgenic tobacco plants expressing ACR2 gene of Arabidopsis thaliana.
    2. ACR2 protein is involved in the conversion of arsenate to arsenite in plant cells.
      Title: In silico and in vivo studies of an Arabidopsis thaliana gene, ACR2, putatively involved in arsenic accumulation in plants.
    3. The effect of AtACR2 knockout or overexpression on arsenic (As) speciation, arsenite efflux from roots and As accumulation in shoots.
      Title: Knocking out ACR2 does not affect arsenic redox status in Arabidopsis thaliana: implications for as detoxification and accumulation in plants.
    4. Arath;CDC25 plays a role in overcoming stress imposed by hydroxyurea, an agent know to induce the DNA replication checkpoint in arabidopsis.
      Title: Arabidopsis T-DNA insertional lines for CDC25 are hypersensitive to hydroxyurea but not to zeocin or salt stress.
    5. Arath;CDC25 can function as a mitotic accelerator, however, expression of Arath;CDC25 was not enhanced in rapidly dividing compared with non-proliferative Arabidopsis tissues. [CDC25]
      Title: The Arabidopsis CDC25 induces a short cell length when overexpressed in fission yeast: evidence for cell cycle function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_120425.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables arsenate reductase (glutaredoxin) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arsenate reductase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in response to arsenic-containing substance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to arsenic-containing substance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Rhodanese/Cell cycle control phosphatase superfamily protein
    NP_568119.1
    • CDC25; FUNCTIONS IN: protein tyrosine phosphatase activity, arsenate reductase activity; INVOLVED IN: protein amino acid phosphorylation, response to arsenic; LOCATED IN: chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Rhodanese-like (InterPro:IPR001763); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      862556..864176
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001342706.1 → NP_001331919.1  Rhodanese/Cell cycle control phosphatase superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BFF8

    2. NM_120425.3 → NP_568119.1  Rhodanese/Cell cycle control phosphatase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568119.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GY31, Q8LC90, Q9LZE1
      UniProtKB/TrEMBL
      A0A178UK97
      Conserved Domains (1) summary
      cd01531
      Location:21 → 130
      Acr2p; Eukaryotic arsenate resistance proteins are members of the Rhodanese Homology Domain superfamily. Included in this CD is the Saccharomyces cerevisiae arsenate reductase protein, Acr2p, and other yeast and plant homologs.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GY31.1

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