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    RUG3 Regulator of chromosome condensation (RCC1) family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836208, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RUG3
    Official Full Name
    Regulator of chromosome condensation (RCC1) family protein
    Primary source
    TAIR:AT5G60870
    Locus tag
    AT5G60870
    See related
    Araport:AT5G60870
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MAE1.11; MAE1_11; RCC1/UVR8/GEF-like 3
    Summary
    Encodes a mitochondrial protein RUG3 that is required for accumulation of mitochondrial respiratory chain complex I. RUG3 is related to human REGULATOR OF CHROMOSOME CONDENSATION 1 (RCC1) and Arabidopsis UV-B RESISTANCE 8 (UVR8).
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    Genomic context

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    See RUG3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (24485655..24487906, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RAB GTPase homolog A1F Neighboring gene breaking of asymmetry in the stomatal lineage Neighboring gene myb domain protein 34

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RUG3 is a negative regulator of plant responses to ABA in Arabidopsis thaliana. Su C, et al. Plant Signal Behav, 2017 Jun 3. PMID 28613105, Free PMC Article
    2. The RCC1 family protein RUG3 is required for splicing of nad2 and complex I biogenesis in mitochondria of Arabidopsis thaliana. Kühn K, et al. Plant J, 2011 Sep. PMID 21623974
    3. RUG3 and ATM synergistically regulate the alternative splicing of mitochondrial nad2 and the DNA damage response in Arabidopsis thaliana. Su C, et al. Sci Rep, 2017 Mar 6. PMID 28262819, Free PMC Article
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data outline a protective mechanism for DNA damage repair and the restoration of mitochondrial function that involves RUG3-mediated mitochondrial retrograde signaling and the activation of an ATM-mediated DNA damage response pathway via modulating the alternative splicing of nad2.
      Title: RUG3 and ATM synergistically regulate the alternative splicing of mitochondrial nad2 and the DNA damage response in Arabidopsis thaliana.
    2. These findings identify RUG3 as a novel regulator of abscissic acid signaling pathway in Arabidopsis thaliana.
      Title: RUG3 is a negative regulator of plant responses to ABA in Arabidopsis thaliana.
    3. RUG3 is required for efficient splicing of the nad2 transcript, and consequently for complex I accumulation in mitochondria. [RUG3]
      Title: The RCC1 family protein RUG3 is required for splicing of nad2 and complex I biogenesis in mitochondria of Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_001085306.1
    NM_001345433.1
    NM_125480.4
    NM_203242.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mitochondrial respiratory chain complex I assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to methyl methanesulfonate IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in vegetative to reproductive phase transition of meristem IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Regulator of chromosome condensation (RCC1) family protein
    NP_001078775.1
    • Regulator of chromosome condensation (RCC1) family protein; FUNCTIONS IN: Ran GTPase binding; INVOLVED IN: biological_process unknown; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: Regulator of chromosome condensation/beta-lactamase-inhibitor protein II (InterPro:IPR009091), Regulator of chromosome condensation, RCC1 (InterPro:IPR000408); BEST Arabidopsis thaliana protein match is: Regulator of chromosome condensation (RCC1) family protein (TAIR:AT3G02510.1); Has 20536 Blast hits to 6008 proteins in 433 species: Archae - 106; Bacteria - 2600; Metazoa - 7212; Fungi - 1292; Plants - 3327; Viruses - 0; Other Eukaryotes - 5999 (source: NCBI BLink).
    NP_200895.2
    • Regulator of chromosome condensation (RCC1) family protein; FUNCTIONS IN: Ran GTPase binding; INVOLVED IN: biological_process unknown; LOCATED IN: mitochondrion; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: Regulator of chromosome condensation/beta-lactamase-inhibitor protein II (InterPro:IPR009091), Regulator of chromosome condensation, RCC1 (InterPro:IPR000408); BEST Arabidopsis thaliana protein match is: Regulator of chromosome condensation (RCC1) family protein (TAIR:AT5G63860.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_974971.2
    • Regulator of chromosome condensation (RCC1) family protein; CONTAINS InterPro DOMAIN/s: Regulator of chromosome condensation/beta-lactamase-inhibitor protein II (InterPro:IPR009091), Regulator of chromosome condensation, RCC1 (InterPro:IPR000408); BEST Arabidopsis thaliana protein match is: Regulator of chromosome condensation (RCC1) family with FYVE zinc finger domain (TAIR:AT5G12350.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      24485655..24487906 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001085306.1 → NP_001078775.1  Regulator of chromosome condensation (RCC1) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078775.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q56Y67
      Conserved Domains (2) summary
      pfam00415
      Location:111 → 160
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam13540
      Location:95 → 122
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat

    2. NM_125480.4 → NP_200895.2  Regulator of chromosome condensation (RCC1) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200895.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3LF49, F4K0I4, Q56Y67, Q9FJG9
      UniProtKB/TrEMBL
      A0A178UK31, A0A5S9YFY2
      Conserved Domains (2) summary
      COG5184
      Location:48 → 411
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00415
      Location:385 → 440
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    3. NM_203242.2 → NP_974971.2  Regulator of chromosome condensation (RCC1) family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4K0I4

    4. NM_001345433.1 → NP_001330471.1  Regulator of chromosome condensation (RCC1) family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BAY4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FJG9.1

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