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    GRF2 growth-regulating factor 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829930, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GRF2
    Official Full Name
    growth-regulating factor 2
    Primary source
    TAIR:AT4G37740
    Locus tag
    AT4G37740
    See related
    Araport:AT4G37740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtGRF2; growth-regulating factor 2; T28I19.20; T28I19_20
    Summary
    Growth regulating factor encoding transcription activator. One of the nine members of a GRF gene family, containing nuclear targeting domain. Mutants result in smaller leaves indicating the role of the gene in leaf development. Expressed in root, shoot and flower
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    Genomic context

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    See GRF2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    4
    Sequence:
    Chromosome: 4; NC_003075.7 (17725337..17727909, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene basic leucine-zipper 7 Neighboring gene ncRNA Neighboring gene Integrase-type DNA-binding superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional specialization of the plant miR396 regulatory network through distinct microRNA-target interactions. Debernardi JM, et al. PLoS Genet, 2012 Jan. PMID 22242012, Free PMC Article
    2. MicroRNA miR396 Regulates the Switch between Stem Cells and Transit-Amplifying Cells in Arabidopsis Roots. Rodriguez RE, et al. Plant Cell, 2015 Dec. PMID 26645252, Free PMC Article
    3. Control of cell proliferation in Arabidopsis thaliana by microRNA miR396. Rodriguez RE, et al. Development, 2010 Jan. PMID 20023165, Free PMC Article
    4. A transcriptional coactivator, AtGIF1, is involved in regulating leaf growth and morphology in Arabidopsis. Kim JH, et al. Proc Natl Acad Sci U S A, 2004 Sep 7. PMID 15326298, Free PMC Article
    5. The AtGRF family of putative transcription factors is involved in leaf and cotyledon growth in Arabidopsis. Kim JH, et al. Plant J, 2003 Oct. PMID 12974814

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_119936.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within leaf development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    growth-regulating factor 2
    NP_195488.2
    • growth-regulating factor 2 (GRF2); CONTAINS InterPro DOMAIN/s: Glutamine-Leucine-Glutamine, QLQ (InterPro:IPR014978), WRC (InterPro:IPR014977); BEST Arabidopsis thaliana protein match is: growth-regulating factor 1 (TAIR:AT2G22840.1); Has 745 Blast hits to 714 proteins in 55 species: Archae - 0; Bacteria - 0; Metazoa - 33; Fungi - 24; Plants - 532; Viruses - 0; Other Eukaryotes - 156 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      17725337..17727909 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119936.5 → NP_195488.2  growth-regulating factor 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195488.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8L8A8, Q9T063
      UniProtKB/TrEMBL
      A0A178UXW8, A0A5S9Y0F1
      Conserved Domains (2) summary
      pfam08879
      Location:228 → 269
      WRC
      pfam08880
      Location:164 → 198
      QLQ
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8L8A8.1

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