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    EX1 UvrB/UvrC domain protein (DUF3506) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829504, updated on 18-Sep-2024

    Summary

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    Official Symbol
    EX1
    Official Full Name
    UvrB/UvrC domain protein (DUF3506)
    Primary source
    TAIR:AT4G33630
    Locus tag
    AT4G33630
    See related
    Araport:AT4G33630
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    EXECUTER1; T16L1.120; T16L1_120
    Summary
    Encodes one of the two plastid proteins EXECUTER (EX1, AT4G33630) and EX2 (AT1G27510). Mediates singlet oxygen induced programmed cell death.
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    Genomic context

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    See EX1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    12
    Sequence:
    Chromosome: 4; NC_003075.7 (16155292..16159578)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene glycine-rich protein Neighboring gene Cysteine proteinases superfamily protein Neighboring gene vacuole protein Neighboring gene ncRNA Neighboring gene costars family protein Neighboring gene ncRNA Neighboring gene dynamin-related protein 3A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Oxidative post-translational modification of EXECUTER1 is required for singlet oxygen sensing in plastids. Dogra V, et al. Nat Commun, 2019 Jun 27. PMID 31249292, Free PMC Article
    2. The genetic basis of singlet oxygen-induced stress responses of Arabidopsis thaliana. Wagner D, et al. Science, 2004 Nov 12. PMID 15539603
    3. The chloroplast singlet oxygen-triggered biosynthesis of salicylic acid and jasmonic acid is mediated by EX1 and GUN1 in Arabidopsis. Geng R, et al. Plant Cell Environ, 2024 Aug. PMID 38600785
    4. 1O2-mediated and EXECUTER-dependent retrograde plastid-to-nucleus signaling in norflurazon-treated seedlings of Arabidopsis thaliana. Kim C, et al. Mol Plant, 2013 Sep. PMID 23376773, Free PMC Article
    5. Chloroplasts of Arabidopsis are the source and a primary target of a plant-specific programmed cell death signaling pathway. Kim C, et al. Plant Cell, 2012 Jul. PMID 22797473, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The chloroplast singlet oxygen-triggered biosynthesis of salicylic acid and jasmonic acid is mediated by EX1 and GUN1 in Arabidopsis.
      Title: The chloroplast singlet oxygen-triggered biosynthesis of salicylic acid and jasmonic acid is mediated by EX1 and GUN1 in Arabidopsis.
    2. Both the substitution of Trp643 with (1)O2-insensitive amino acids and the deletion of the DUF3506 domain abolish the EX1-mediated (1)O2 signaling.
      Title: Oxidative post-translational modification of EXECUTER1 is required for singlet oxygen sensing in plastids.
    3. The initiation of (1)O2 signaling in grana margins depends on EX1 and the ATP-dependent zinc metalloprotease FtsH. As FtsH cleaves also the D1 protein during the disassembly of damaged PSII, EX1- and (1)O2-mediated signaling seems to be not only spatially but also functionally associated with the repair of PSII
      Title: Singlet oxygen- and EXECUTER1-mediated signaling is initiated in grana margins and depends on the protease FtsH2.
    4. Singlet oxygen-mediated and EXECUTER-dependent retrograde signaling was induced, , in seedlings first exposed to norflurazon after light-dependent chloroplast formation had been completed.
      Title: 1O2-mediated and EXECUTER-dependent retrograde plastid-to-nucleus signaling in norflurazon-treated seedlings of Arabidopsis thaliana.
    5. Singlet oxygen-mediated cell death originates within chloroplasts and is initiated by the activation of an EX1/EX2-dependent signaling pathway.
      Title: Chloroplasts of Arabidopsis are the source and a primary target of a plant-specific programmed cell death signaling pathway.
    6. The impact of the EXECUTER1 utation and the prevalence of enzymatic or non-enzymatic lipid peroxidation on the modes of singlet oxygen activity in flu mutant A. thaliana is reported.
      Title: Enzymatic, but not non-enzymatic, 1O2-mediated peroxidation of polyunsaturated fatty acids forms part of the EXECUTER1-dependent stress response program in the flu mutant of Arabidopsis thaliana.
    7. inactivation of a single gene, EXECUTER1, is sufficient to abrogate stress responses of Arabidopsis thaliana caused by the release of singlet oxygen. [EXECUTER1]
      Title: The genetic basis of singlet oxygen-induced stress responses of Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001342225.1
    NM_119519.4
    NM_179157.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to singlet oxygen IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within singlet oxygen-mediated programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in thylakoid IDA
    Inferred from Direct Assay
    more info
    		  
    located_in thylakoid membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UvrB/UvrC domain protein (DUF3506)
    NP_567929.1
    • EXECUTER1 (EX1); FUNCTIONS IN: DNA binding, nuclease activity; INVOLVED IN: response to singlet oxygen; LOCATED IN: thylakoid membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF3506 (InterPro:IPR021894), UvrB/UvrC protein (InterPro:IPR001943); BEST Arabidopsis thaliana protein match is: Protein of unknown function (DUF3506) (TAIR:AT1G27510.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_849488.1
    • EXECUTER1 (EX1); FUNCTIONS IN: DNA binding, nuclease activity; INVOLVED IN: response to singlet oxygen; LOCATED IN: thylakoid membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF3506 (InterPro:IPR021894), UvrB/UvrC protein (InterPro:IPR001943); BEST Arabidopsis thaliana protein match is: Protein of unknown function (DUF3506) (TAIR:AT1G27510.1); Has 324 Blast hits to 312 proteins in 85 species: Archae - 0; Bacteria - 8; Metazoa - 98; Fungi - 41; Plants - 94; Viruses - 5; Other Eukaryotes - 78 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      16155292..16159578
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119519.4 → NP_567929.1  UvrB/UvrC domain protein (DUF3506) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567929.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81880, Q93YW0
      UniProtKB/TrEMBL
      A0A178V4X2, A0A5S9XYD0, A0A7G2F7T0
      Conserved Domains (2) summary
      pfam02151
      Location:127 → 153
      UVR; UvrB/uvrC motif
      pfam12014
      Location:521 → 652
      DUF3506; Domain of unknown function (DUF3506)

    2. NM_179157.3 → NP_849488.1  UvrB/UvrC domain protein (DUF3506) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849488.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81880, Q93YW0
      UniProtKB/TrEMBL
      A0A178V4X2, A0A5S9XYD0, A0A7G2F7T0
      Conserved Domains (2) summary
      pfam02151
      Location:127 → 153
      UVR; UvrB/uvrC motif
      pfam12014
      Location:521 → 652
      DUF3506; Domain of unknown function (DUF3506)

    3. NM_001342225.1 → NP_001328575.1  UvrB/UvrC domain protein (DUF3506) [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81880, Q93YW0
      UniProtKB/TrEMBL
      A0A178V4X2, A0A5S9XYD0, A0A7G2F7T0
      Conserved Domains (2) summary
      pfam02151
      Location:127 → 153
      UVR; UvrB/uvrC motif
      pfam12014
      Location:521 → 652
      DUF3506; Domain of unknown function (DUF3506)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93YW0.1

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