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    LpxA bacterial transferase hexapeptide repeat-containing protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829075, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LpxA
    Official Full Name
    bacterial transferase hexapeptide repeat-containing protein
    Primary source
    TAIR:AT4G29540
    Locus tag
    AT4G29540
    See related
    Araport:AT4G29540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtLpxA; T16L4.50; T16L4_50
    Summary
    Encodes a UDP-N-acetylglucosamine acyltransferase.
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    Genomic context

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    See LpxA in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    9
    Sequence:
    Chromosome: 4; NC_003075.7 (14497560..14500504)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene arginine methyltransferase 11 Neighboring gene nucleophosmin Neighboring gene Pyridoxal phosphate phosphatase-related protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene hypothetical protein (DUF626)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Activity and crystal structure of Arabidopsis thaliana UDP-N-acetylglucosamine acyltransferase. Joo SH, et al. Biochemistry, 2012 May 29. PMID 22545860, Free PMC Article
    2. Pathway for lipid A biosynthesis in Arabidopsis thaliana resembling that of Escherichia coli. Li C, et al. Proc Natl Acad Sci U S A, 2011 Jul 12. PMID 21709257, Free PMC Article
    3. In-depth temporal transcriptome profiling reveals a crucial developmental switch with roles for RNA processing and organelle metabolism that are essential for germination in Arabidopsis. Narsai R, et al. Plant Physiol, 2011 Nov. PMID 21908688, Free PMC Article
    4. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article
    5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001036672.2
    NM_119099.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid X metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bacterial transferase hexapeptide repeat-containing protein
    NP_001031749.1
    • bacterial transferase hexapeptide repeat-containing protein; FUNCTIONS IN: acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity, transferase activity; INVOLVED IN: lipid biosynthetic process; EXPRESSED IN: 7 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Trimeric LpxA-like (InterPro:IPR011004), Bacterial transferase hexapeptide repeat (InterPro:IPR001451), Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (InterPro:IPR010137); BEST Arabidopsis thaliana protein match is: Trimeric LpxA-like enzymes superfamily protein (TAIR:AT4G05210.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_194683.2
    • bacterial transferase hexapeptide repeat-containing protein; FUNCTIONS IN: acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity, transferase activity; INVOLVED IN: lipid biosynthetic process; EXPRESSED IN: 7 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Trimeric LpxA-like (InterPro:IPR011004), Bacterial transferase hexapeptide repeat (InterPro:IPR001451), Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (InterPro:IPR010137); BEST Arabidopsis thaliana protein match is: Trimeric LpxA-like enzymes superfamily protein (TAIR:AT4G05210.1); Has 13439 Blast hits to 13165 proteins in 2031 species: Archae - 84; Bacteria - 8805; Metazoa - 8; Fungi - 21; Plants - 66; Viruses - 3; Other Eukaryotes - 4452 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      14497560..14500504
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001341970.1 → NP_001329097.1  bacterial transferase hexapeptide repeat-containing protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B6N8
      Conserved Domains (1) summary
      cl00160
      Location:12 → 230
      LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...

    2. NM_001341971.1 → NP_001329098.1  bacterial transferase hexapeptide repeat-containing protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B6P1
      Conserved Domains (1) summary
      cl00160
      Location:41 → 203
      LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...

    3. NM_001036672.2 → NP_001031749.1  bacterial transferase hexapeptide repeat-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031749.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8H1Q9, Q9SU91
      UniProtKB/TrEMBL
      A0A178V128, A0A5S9XX16, A0A654FUF5
      Conserved Domains (1) summary
      cd03351
      Location:41 → 325
      LbH_UDP-GlcNAc_AT; UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic ...

    4. NM_119099.3 → NP_194683.2  bacterial transferase hexapeptide repeat-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194683.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FUF5
      Conserved Domains (2) summary
      cd03351
      Location:41 → 323
      LbH_UDP-GlcNAc_AT; UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic ...
      PRK05289
      Location:37 → 327
      PRK05289; UDP-N-acetylglucosamine acyltransferase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SU91.1

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