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    GrxC5 Glutaredoxin family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828994, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GrxC5
    Official Full Name
    Glutaredoxin family protein
    Primary source
    TAIR:AT4G28730
    Locus tag
    AT4G28730
    See related
    Araport:AT4G28730
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F16A16.160; F16A16_160; glutaredoxin C5
    Summary
    Encodes a glutaredoxin GrxC5. GrxC5 exists as two forms when expressed in Escherichia coli. The monomeric apoprotein possesses deglutathionylation activity mediating the recycling of plastidial methionine sulfoxide reductase B1 and peroxiredoxin IIE, whereas the dimeric holoprotein incorporates a [2Fe-2S] cluster.
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    Genomic context

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    See GrxC5 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    4
    Sequence:
    Chromosome: 4; NC_003075.7 (14199043..14200903)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene pfkB-like carbohydrate kinase family protein Neighboring gene Myosin family protein with Dil domain-containing protein Neighboring gene Flavin-binding monooxygenase family protein Neighboring gene LOW PSII ACCUMULATION-like protein Neighboring gene uncharacterized protein Neighboring gene Photosystem I reaction centre subunit IV / PsaE protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis chloroplastic glutaredoxin C5 as a model to explore molecular determinants for iron-sulfur cluster binding into glutaredoxins. Couturier J, et al. J Biol Chem, 2011 Aug 5. PMID 21632542, Free PMC Article
    2. Monothiol glutaredoxin-BolA interactions: redox control of Arabidopsis thaliana BolA2 and SufE1. Couturier J, et al. Mol Plant, 2014 Jan. PMID 24203231
    3. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
    4. Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. Zybailov B, et al. PLoS One, 2008 Apr 23. PMID 18431481, Free PMC Article
    5. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001341931.1
    NM_119017.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables glutathione-disulfide reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within iron-sulfur cluster assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Glutaredoxin family protein
    NP_194602.2
    • Glutaredoxin family protein; FUNCTIONS IN: electron carrier activity, protein disulfide oxidoreductase activity; INVOLVED IN: cell redox homeostasis; LOCATED IN: chloroplast; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Glutaredoxin (InterPro:IPR002109), Glutaredoxin subgroup (InterPro:IPR014025), Glutaredoxin, eukaryotic/virial (InterPro:IPR011899), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: Thioredoxin superfamily protein (TAIR:AT2G20270.1); Has 4412 Blast hits to 4405 proteins in 1169 species: Archae - 6; Bacteria - 1982; Metazoa - 422; Fungi - 333; Plants - 692; Viruses - 111; Other Eukaryotes - 866 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      14199043..14200903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119017.5 → NP_194602.2  Glutaredoxin family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194602.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GWS0, Q9SVU1
      UniProtKB/TrEMBL
      A0A178UXL4, A0A5S9XYX7
      Conserved Domains (1) summary
      cd03419
      Location:82 → 161
      GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...

    2. NM_001341931.1 → NP_001328515.1  Glutaredoxin family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B4W9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GWS0.1

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