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    HISN5B HISTIDINE BIOSYNTHESIS 5B [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827149, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HISN5B
    Official Full Name
    HISTIDINE BIOSYNTHESIS 5B
    Primary source
    TAIR:AT4G14910
    Locus tag
    AT4G14910
    See related
    Araport:AT4G14910
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    DL3495C; FCAALL.36; HISTIDINE BIOSYNTHESIS 5B
    Summary
    Encodes a protein that is predicted to act as a imidazoleglycerol-phosphate dehydratase involved in histidine biosynthesis
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    Genomic context

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    See HISN5B in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    8
    Sequence:
    Chromosome: 4; NC_003075.7 (8528033..8530437, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene FRIGIDA-like protein Neighboring gene 2Fe-2S ferredoxin-like superfamily protein Neighboring gene Galactose oxidase/kelch repeat superfamily protein Neighboring gene Acyl-CoA N-acyltransferase with RING/FYVE/PHD-type zinc finger protein Neighboring gene ncRNA Neighboring gene Survival protein SurE-like phosphatase/nucleotidase Neighboring gene amine oxidase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal Structures Reveal that the Reaction Mechanism of Imidazoleglycerol-Phosphate Dehydratase Is Controlled by Switching Mn(II) Coordination. Bisson C, et al. Structure, 2015 Jul 7. PMID 26095028, Free PMC Article
    2. Purification, crystallization and preliminary crystallographic analysis of Arabidopsis thaliana imidazoleglycerol-phosphate dehydratase. Glynn SE, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2005 Aug 1. PMID 16511155, Free PMC Article
    3. Genetic dissection of histidine biosynthesis in Arabidopsis. Muralla R, et al. Plant Physiol, 2007 Jun. PMID 17434988, Free PMC Article
    4. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article
    5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crustal structure of A. thaliana IGPD isoform 2 (IGPD2) in complex with inorganic phosphate.
      Title: Crystal Structures Reveal that the Reaction Mechanism of Imidazoleglycerol-Phosphate Dehydratase Is Controlled by Switching Mn(II) Coordination.
    2. preliminary X ray structure
      Title: Purification, crystallization and preliminary crystallographic analysis of Arabidopsis thaliana imidazoleglycerol-phosphate dehydratase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001084922.2
    NM_001203805.2
    NM_117577.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables imidazoleglycerol-phosphate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables imidazoleglycerol-phosphate dehydratase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables imidazoleglycerol-phosphate dehydratase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-histidine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within L-histidine biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    HISTIDINE BIOSYNTHESIS 5B
    NP_001078391.1
    • HISTIDINE BIOSYNTHESIS 5B (HISN5B); FUNCTIONS IN: imidazoleglycerol-phosphate dehydratase activity; INVOLVED IN: histidine biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Imidazoleglycerol-phosphate dehydratase, conserved site (InterPro:IPR020565), Ribosomal protein S5 domain 2-type fold (InterPro:IPR020568), Imidazoleglycerol-phosphate dehydratase (InterPro:IPR000807); BEST Arabidopsis thaliana protein match is: imidazoleglycerol-phosphate dehydratase (TAIR:AT3G22425.2); Has 6849 Blast hits to 6847 proteins in 2200 species: Archae - 198; Bacteria - 4094; Metazoa - 4; Fungi - 191; Plants - 87; Viruses - 0; Other Eukaryotes - 2275 (source: NCBI BLink).
    NP_001190734.1
    • HISTIDINE BIOSYNTHESIS 5B (HISN5B); FUNCTIONS IN: imidazoleglycerol-phosphate dehydratase activity; INVOLVED IN: histidine biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Imidazoleglycerol-phosphate dehydratase, conserved site (InterPro:IPR020565), Ribosomal protein S5 domain 2-type fold (InterPro:IPR020568), Imidazoleglycerol-phosphate dehydratase (InterPro:IPR000807); BEST Arabidopsis thaliana protein match is: imidazoleglycerol-phosphate dehydratase (TAIR:AT3G22425.2).
    NP_567448.1
    • HISTIDINE BIOSYNTHESIS 5B (HISN5B); FUNCTIONS IN: imidazoleglycerol-phosphate dehydratase activity; INVOLVED IN: histidine biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Imidazoleglycerol-phosphate dehydratase, conserved site (InterPro:IPR020565), Ribosomal protein S5 domain 2-type fold (InterPro:IPR020568), Imidazoleglycerol-phosphate dehydratase (InterPro:IPR000807); BEST Arabidopsis thaliana protein match is: imidazoleglycerol-phosphate dehydratase (TAIR:AT3G22425.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      8528033..8530437 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_117577.4 → NP_567448.1  HISTIDINE BIOSYNTHESIS 5B [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567448.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23346, Q94AE6
      UniProtKB/TrEMBL
      A0A178V571, A0A5S9XSG5, A0A654FPS2
      Conserved Domains (1) summary
      PLN02800
      Location:1 → 271
      PLN02800; imidazoleglycerol-phosphate dehydratase

    2. NM_001084922.2 → NP_001078391.1  HISTIDINE BIOSYNTHESIS 5B [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078391.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V3L2, A0A654FPS2, A8MQQ8
      Conserved Domains (2) summary
      PLN02800
      Location:1 → 263
      PLN02800; imidazoleglycerol-phosphate dehydratase
      PRK00951
      Location:74 → 261
      hisB; imidazoleglycerol-phosphate dehydratase; Validated

    3. NM_001203805.2 → NP_001190734.1  HISTIDINE BIOSYNTHESIS 5B [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190734.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FPS2, F4JIH9
      Conserved Domains (2) summary
      PLN02800
      Location:1 → 263
      PLN02800; imidazoleglycerol-phosphate dehydratase
      PRK00951
      Location:74 → 261
      hisB; imidazoleglycerol-phosphate dehydratase; Validated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O23346.2

    Gene LinkOut

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