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    AAE15 acyl-activating enzyme 15 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827043, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AAE15
    Official Full Name
    acyl-activating enzyme 15
    Primary source
    TAIR:AT4G14070
    Locus tag
    AT4G14070
    See related
    Araport:AT4G14070
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    acyl-activating enzyme 15; DL3075C; FCAALL.81
    Summary
    Plastidic acyl activating enzyme involved in the elongation of exogenous medium-chain fatty acids to 16- and 18-carbon fatty acids.
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    Genomic context

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    See AAE15 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    18
    Sequence:
    Chromosome: 4; NC_003075.7 (8111944..8118188, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Polyketide cyclase/dehydrase and lipid transport superfamily protein Neighboring gene ncRNA Neighboring gene O-Glycosyl hydrolases family 17 protein Neighboring gene transferases, transferring glycosyl groups Neighboring gene UDP-Glycosyltransferase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a plastid acyl-acyl carrier protein synthetase in Arabidopsis and its role in the activation and elongation of exogenous fatty acids. Koo AJ, et al. Plant J, 2005 Nov. PMID 16262711
    2. Disruption of plastid acyl:acyl carrier protein synthetases increases medium chain fatty acid accumulation in seeds of transgenic Arabidopsis. Tjellström H, et al. FEBS Lett, 2013 Apr 2. PMID 23454211
    3. Proteomics of the chloroplast envelope membranes from Arabidopsis thaliana. Ferro M, et al. Mol Cell Proteomics, 2003 May. PMID 12766230
    4. Proteomic study of the Arabidopsis thaliana chloroplastic envelope membrane utilizing alternatives to traditional two-dimensional electrophoresis. Froehlich JE, et al. J Proteome Res, 2003 Jul-Aug. PMID 12938931
    5. AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins. Ferro M, et al. Mol Cell Proteomics, 2010 Jun. PMID 20061580, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results indicate AAE15 (AT4G14070)/ AAE16 (At3g23790) are involved in activation of plastid synthesized medium-chain fatty acids (MCFA) as well as those supplied exogenously to plant tissues.
      Title: Disruption of plastid acyl:acyl carrier protein synthetases increases medium chain fatty acid accumulation in seeds of transgenic Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    NM_117482.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables long-chain fatty acid [acyl-carrier-protein] ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fatty acid elongation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in plastid HDA PubMed 
    located_in plastid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    acyl-activating enzyme 15
    NP_193143.2
    • acyl-activating enzyme 15 (AAE15); FUNCTIONS IN: long-chain fatty acid [acyl-carrier-protein] ligase activity; INVOLVED IN: fatty acid elongation; LOCATED IN: chloroplast, plastid, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: AMP-dependent synthetase and ligase family protein (TAIR:AT3G23790.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      8111944..8118188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_117482.4 → NP_193143.2  acyl-activating enzyme 15 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193143.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23268, Q56X36, Q8LRT2, Q8W471
      UniProtKB/TrEMBL
      A0A178V0U4
      Conserved Domains (2) summary
      cd05907
      Location:126 → 714
      VL_LC_FACS_like; Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases
      COG1022
      Location:98 → 727
      FAA1; Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8W471.1

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