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    CUL1 cullin 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825648, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CUL1
    Official Full Name
    cullin 1
    Primary source
    TAIR:AT4G02570
    Locus tag
    AT4G02570
    See related
    Araport:AT4G02570
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCUL1; AUXIN RESISTANT 6; AXR6; cullin 1; T10P11.26; T10P11_26
    Summary
    Encodes a cullin that is a component of SCF ubiquitin ligase complexes involved in mediating responses to auxin and jasmonic acid. Homozygous auxin-resistant mutants arrest growth soon after germination, lacking a root and hypocotyl. Heterozygotes display a variety of phenotypes consistent with impaired auxin response.
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    Genomic context

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    See CUL1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    20
    Sequence:
    Chromosome: 4; NC_003075.7 (1128515..1133774)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Homeodomain-like superfamily protein Neighboring gene NADH-ubiquinone oxidoreductase 24 kDa subunit Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of cul1-7, a recessive allele of CULLIN1 that disrupts SCF function at the C terminus of CUL1 in Arabidopsis thaliana. Gilkerson J, et al. Genetics, 2009 Mar. PMID 19114460, Free PMC Article
    2. incurvata13, a novel allele of AUXIN RESISTANT6, reveals a specific role for auxin and the SCF complex in Arabidopsis embryogenesis, vascular specification, and leaf flatness. Esteve-Bruna D, et al. Plant Physiol, 2013 Mar. PMID 23319550, Free PMC Article
    3. The axr6 mutants of Arabidopsis thaliana define a gene involved in auxin response and early development. Hobbie L, et al. Development, 2000 Jan. PMID 10654597
    4. A novel viable allele of Arabidopsis CULLIN1 identified in a screen for superroot2 suppressors by next generation sequencing-assisted mapping. Pacurar DI, et al. PLoS One, 2014. PMID 24955772, Free PMC Article
    5. Null mutation of AtCUL1 causes arrest in early embryogenesis in Arabidopsis. Shen WH, et al. Mol Biol Cell, 2002 Jun. PMID 12058059, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. downregulation of CSN4 in Arabidopsis and in tobacco cells leads to delayed G1/S transition comparable to that observed when TCTP is downregulated. Loss-of-function of AtTCTP leads to increased fraction of deneddylated CUL1, suggesting that AtTCTP interferes negatively with COP9 function. Similar defects in cell proliferation and CUL1 neddylation status were observed in Drosophila knockdown for dCSN4 or dTCTP
      Title: TCTP and CSN4 control cell cycle progression and development by regulating CULLIN1 neddylation in plants and animals.
    2. ALF4 binds to RBX1 and inhibits the activity of SCF(TIR)(1), an E3 ligase responsible for degradation of the Aux/IAA transcriptional repressors. In vivo, the alf4 mutation destabilizes the CUL1 subunit of the SCF
      Title: The Arabidopsis ALF4 protein is a regulator of SCF E3 ligases.
    3. The axr6-101 phenotype is caused by the E716K substitution of the CUL1 protein, which is likely to affect its ability to bind to the C-terminal RING domain of RING-box 1 (RBX1).
      Title: A new temperature-insensitive allele of the Arabidopsis AXR6/CUL1 locus derived from a missense mutation in the C-terminal RBX1 binding region.
    4. a new viable recessive allele of the Arabidopsis CULLIN1 gene in the non-reference Wassilewskija (Ws-4) accession, was identified.
      Title: A novel viable allele of Arabidopsis CULLIN1 identified in a screen for superroot2 suppressors by next generation sequencing-assisted mapping.
    5. icu13 is a novel recessive allele of AUXIN RESISTANT6 (AXR6), which encodes CULLIN1, an invariable component of the SCF complex.[ICU13] [ncurvata13]
      Title: incurvata13, a novel allele of AUXIN RESISTANT6, reveals a specific role for auxin and the SCF complex in Arabidopsis embryogenesis, vascular specification, and leaf flatness.
    6. CUL1-based SCF E3 ligase activity is required for Della protein degradation.
      Title: Biochemical insights on degradation of Arabidopsis DELLA proteins gained from a cell-free assay system.
    7. the first reported allele of CUL1 to directly affect subunit interactions at the CUL1 C terminus
      Title: Isolation and characterization of cul1-7, a recessive allele of CULLIN1 that disrupts SCF function at the C terminus of CUL1 in Arabidopsis thaliana.
    8. CUL1 is required for TOC1 degradation and suggests that this protein is the functional cullin circadian clock.
      Title: CUL1 regulates TOC1 protein stability in the Arabidopsis circadian clock.
    9. The disruption of the CAND1-CUL1 interaction results in an increased abundance of assembled SCF(TIR1) complex; stabilization of the CAND1-CUL1 interaction diminishes SCF(TIR1) complex abundance.
      Title: Genetic analysis of CAND1-CUL1 interactions in Arabidopsis supports a role for CAND1-mediated cycling of the SCFTIR1 complex.
    10. Genetic and physiological data to directly demonstrate that AtCUL1 is necessary for normal JA responses are presented.
      Title: Point mutations in Arabidopsis Cullin1 reveal its essential role in jasmonate response.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001036498.3
    NM_001036499.1
    NM_001203732.1
    NM_116491.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within SCF complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within jasmonic acid mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phloem or xylem histogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to auxin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to jasmonic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in phragmoplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cullin 1
    NP_001031575.1
    • cullin 1 (CUL1); CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Cullin protein, neddylation domain (InterPro:IPR019559), Cullin homology (InterPro:IPR016158), Cullin, N-terminal (InterPro:IPR001373), Cullin, conserved site (InterPro:IPR016157), Cullin repeat-like-containing domain (InterPro:IPR016159); BEST Arabidopsis thaliana protein match is: cullin 2 (TAIR:AT1G02980.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_001031576.1
    • cullin 1 (CUL1); CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Cullin protein, neddylation domain (InterPro:IPR019559), Cullin homology (InterPro:IPR016158), Cullin, N-terminal (InterPro:IPR001373), Cullin, conserved site (InterPro:IPR016157), Cullin repeat-like-containing domain (InterPro:IPR016159); BEST Arabidopsis thaliana protein match is: cullin 2 (TAIR:AT1G02980.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_001190661.1
    • cullin 1 (CUL1); CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Cullin homology (InterPro:IPR016158), Cullin protein, neddylation domain (InterPro:IPR019559), Cullin, conserved site (InterPro:IPR016157), Cullin, N-terminal (InterPro:IPR001373), Cullin repeat-like-containing domain (InterPro:IPR016159); BEST Arabidopsis thaliana protein match is: cullin 2 (TAIR:AT1G02980.1).
    NP_567243.1
    • cullin 1 (CUL1); CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Cullin protein, neddylation domain (InterPro:IPR019559), Cullin homology (InterPro:IPR016158), Cullin, N-terminal (InterPro:IPR001373), Cullin, conserved site (InterPro:IPR016157), Cullin repeat-like-containing domain (InterPro:IPR016159); BEST Arabidopsis thaliana protein match is: cullin 2 (TAIR:AT1G02980.1); Has 2243 Blast hits to 2199 proteins in 231 species: Archae - 0; Bacteria - 0; Metazoa - 958; Fungi - 500; Plants - 373; Viruses - 0; Other Eukaryotes - 412 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      1128515..1133774
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001203732.1 → NP_001190661.1  cullin 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190661.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22770, Q56W31, Q94AH6
      UniProtKB/TrEMBL
      A0A178V3S3, A0A654FLK1, B9DGE3
      Conserved Domains (2) summary
      pfam00888
      Location:12 → 641
      Cullin; Cullin family
      pfam10557
      Location:668 → 729
      Cullin_Nedd8; Cullin protein neddylation domain

    2. NM_116491.3 → NP_567243.1  cullin 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567243.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22770, Q56W31, Q94AH6
      UniProtKB/TrEMBL
      A0A178V3S3, A0A654FLK1, B9DGE3
      Conserved Domains (2) summary
      pfam00888
      Location:12 → 641
      Cullin; Cullin family
      pfam10557
      Location:668 → 729
      Cullin_Nedd8; Cullin protein neddylation domain

    3. NM_001036498.3 → NP_001031575.1  cullin 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031575.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22770, Q56W31, Q94AH6
      UniProtKB/TrEMBL
      A0A178V3S3, A0A654FLK1, B9DGE3
      Conserved Domains (2) summary
      pfam00888
      Location:12 → 641
      Cullin; Cullin family
      pfam10557
      Location:668 → 729
      Cullin_Nedd8; Cullin protein neddylation domain

    4. NM_001036499.1 → NP_001031576.1  cullin 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031576.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22770, Q56W31, Q94AH6
      UniProtKB/TrEMBL
      A0A178V3S3, A0A654FLK1, B9DGE3
      Conserved Domains (2) summary
      pfam00888
      Location:12 → 641
      Cullin; Cullin family
      pfam10557
      Location:668 → 729
      Cullin_Nedd8; Cullin protein neddylation domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94AH6.1

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