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    CEP2 Cysteine proteinases superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 823992, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CEP2
    Official Full Name
    Cysteine proteinases superfamily protein
    Primary source
    TAIR:AT3G48340
    Locus tag
    AT3G48340
    See related
    Araport:AT3G48340
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    cysteine endopeptidase 2
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    Genomic context

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    See CEP2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    3
    Sequence:
    Chromosome: 3; NC_003074.8 (17897506..17899351)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 71, subfamily A, polypeptide 21 Neighboring gene protein-l-isoaspartate methyltransferase 1 Neighboring gene tRNA-Thr Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ex vivo processing for maturation of Arabidopsis KDEL-tailed cysteine endopeptidase 2 (AtCEP2) pro-enzyme and its storage in endoplasmic reticulum derived organelles. Hierl G, et al. Plant Mol Biol, 2014 Apr. PMID 24287716, Free PMC Article
    2. The role of KDEL-tailed cysteine endopeptidases of Arabidopsis (AtCEP2 and AtCEP1) in root development. Höwing T, et al. PLoS One, 2018. PMID 30576358, Free PMC Article
    3. Proteomic profiling of tandem affinity purified 14-3-3 protein complexes in Arabidopsis thaliana. Chang IF, et al. Proteomics, 2009 Jun. PMID 19452453, Free PMC Article
    4. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of AtCEP2, but not AtCEP1 resulted in shorter primary roots due to a decrease in cell length in the lateral root (LR) cap and impairs extension of primary root epidermis. AtCEP1 and AtCEP2 are expressed in root epidermis cells that are separated for LR emergence. Loss of AtCEP1 or AtCEP2 caused delayed emergence of LR primordia.
      Title: The role of KDEL-tailed cysteine endopeptidases of Arabidopsis (AtCEP2 and AtCEP1) in root development.
    2. The purified AtCEP2 was activated in a pH-dependent manner. Protease activity was pH-independent after activation. Analysis of substrate specificity showed that AtCEP2 accepts proline near the cleavage site.
      Title: Ex vivo processing for maturation of Arabidopsis KDEL-tailed cysteine endopeptidase 2 (AtCEP2) pro-enzyme and its storage in endoplasmic reticulum derived organelles.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_148860.5

    Gene Ontology Provided by TAIR

    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Cysteine proteinases superfamily protein
    NP_680113.3
    • Cysteine proteinases superfamily protein; FUNCTIONS IN: cysteine-type peptidase activity, protein binding; INVOLVED IN: proteolysis; LOCATED IN: endomembrane system; CONTAINS InterPro DOMAIN/s: Peptidase C1A, papain (InterPro:IPR013128), Proteinase inhibitor I29, cathepsin propeptide (InterPro:IPR013201), Peptidase C1A, papain C-terminal (InterPro:IPR000668), Peptidase, cysteine peptidase active site (InterPro:IPR000169); BEST Arabidopsis thaliana protein match is: Cysteine proteinases superfamily protein (TAIR:AT3G48350.1); Has 8084 Blast hits to 8002 proteins in 732 species: Archae - 65; Bacteria - 255; Metazoa - 3301; Fungi - 6; Plants - 1876; Viruses - 137; Other Eukaryotes - 2444 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      17897506..17899351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_148860.5 → NP_680113.3  Cysteine proteinases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_680113.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9STL4
      UniProtKB/TrEMBL
      A0A178VA93, A0A5S9XIW6, A0A7G2EUX0
      Conserved Domains (2) summary
      pfam00112
      Location:128 → 343
      Peptidase_C1; Papain family cysteine protease
      pfam08246
      Location:38 → 93
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9STL4.1

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