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    ACT12 actin-12 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 823805, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ACT12
    Official Full Name
    actin-12
    Primary source
    TAIR:AT3G46520
    Locus tag
    AT3G46520
    See related
    Araport:AT3G46520
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ACTIN; actin-12
    Summary
    Member of actin subclass composed of ACT12 and ACT4. RNA is expressed at very low levels in vegetative organs, low levels in flowers and very high levels in pollen. Expression of an ACT12/GUS fusion was found in vascular tissues, tapetum, developing and mature pollen, the root cap and in a ring of pericycle tissues during lateral root initiation and early development.
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    Genomic context

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    See ACT12 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    6
    Sequence:
    Chromosome: 3; NC_003074.8 (17128211..17131466)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein Neighboring gene plant U-box 13 Neighboring gene NB-ARC domain-containing disease resistance protein Neighboring gene ENTH/VHS family protein Neighboring gene ncRNA Neighboring gene Fasciclin-like arabinogalactan family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An actin remodeling role for Arabidopsis processing bodies revealed by their proximity interactome. Liu C, et al. EMBO J, 2023 May 2. PMID 36741000, Free PMC Article
    2. The formin homology 1 domain modulates the actin nucleation and bundling activity of Arabidopsis FORMIN1. Michelot A, et al. Plant Cell, 2005 Aug. PMID 15994911, Free PMC Article
    3. Cloning and functional characterization of a formin-like protein (AtFH8) from Arabidopsis. Yi K, et al. Plant Physiol, 2005 Jun. PMID 15923338, Free PMC Article
    4. KATAMARI1/MURUS3 Is a novel golgi membrane protein that is required for endomembrane organization in Arabidopsis. Tamura K, et al. Plant Cell, 2005 Jun. PMID 15863516, Free PMC Article
    5. Plant formin AtFH5 is an evolutionarily conserved actin nucleator involved in cytokinesis. Ingouff M, et al. Nat Cell Biol, 2005 Apr. PMID 15765105

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An actin remodeling role for Arabidopsis processing bodies revealed by their proximity interactome.
      Title: An actin remodeling role for Arabidopsis processing bodies revealed by their proximity interactome.
    2. Data indicate that the construction of actin collars was affected in vln2 vln5 double mutantpollen tubes.
      Title: Arabidopsis villins promote actin turnover at pollen tube tips and facilitate the construction of actin collars.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_114519.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables structural constituent of cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within cytoskeleton organization TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoskeleton TAS
    Traceable Author Statement
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    actin-12
    NP_190236.1
    • actin-12 (ACT12); FUNCTIONS IN: structural constituent of cytoskeleton; INVOLVED IN: cytoskeleton organization; LOCATED IN: mitochondrion, cytoskeleton; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, 4 anthesis, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Actin, conserved site (InterPro:IPR004001), Actin/actin-like (InterPro:IPR004000), Actin/actin-like conserved site (InterPro:IPR020902); BEST Arabidopsis thaliana protein match is: actin 4 (TAIR:AT5G59370.2); Has 15176 Blast hits to 14784 proteins in 3040 species: Archae - 8; Bacteria - 8; Metazoa - 5711; Fungi - 5220; Plants - 1602; Viruses - 2; Other Eukaryotes - 2625 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      17128211..17131466
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001339262.1 → NP_001327017.1  actin-12 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P53497
      UniProtKB/TrEMBL
      A0A178VHX9, A0A654FI89, Q84W24
      Conserved Domains (1) summary
      cl17037
      Location:5 → 377
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    2. NM_114519.3 → NP_190236.1  actin-12 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190236.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P53497
      UniProtKB/TrEMBL
      A0A178VHX9, A0A654FI89, Q84W24
      Conserved Domains (1) summary
      cl17037
      Location:5 → 377
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53497.1

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