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    CLE19 CLAVATA3/ESR-RELATED 19 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 822009, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CLE19
    Official Full Name
    CLAVATA3/ESR-RELATED 19
    Primary source
    TAIR:AT3G24225
    Locus tag
    AT3G24225
    See related
    Araport:AT3G24225
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCLE19; CLAVATA3/ESR-RELATED 19; EMBRYO SURROUNDING REGION 19; ESR19
    Summary
    Member of a large family of putative ligands homologous to the Clavata3 gene. Consists of a single exon. Can partially replace CLV3 function in vivo. Regulates root meristem size in a SCR and SHR-independent pathway.
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    Genomic context

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    See CLE19 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    1
    Sequence:
    Chromosome: 3; NC_003074.8 (8768846..8769695)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Ankyrin repeat family protein Neighboring gene nine-cis-epoxycarotenoid dioxygenase 6 Neighboring gene ncRNA Neighboring gene Pectate lyase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cytological and Transcriptomic Analyses Reveal Important Roles of CLE19 in Pollen Exine Formation. Wang S, et al. Plant Physiol, 2017 Nov. PMID 28916592, Free PMC Article
    2. CLE19 expressed in the embryo regulates both cotyledon establishment and endosperm development in Arabidopsis. Xu TT, et al. J Exp Bot, 2015 Aug. PMID 26071532, Free PMC Article
    3. SUPPRESSOR OF LLP1 1-mediated C-terminal processing is critical for CLE19 peptide activity. Tamaki T, et al. Plant J, 2013 Dec. PMID 24118638
    4. Root-specific CLE19 overexpression and the sol1/2 suppressors implicate a CLV-like pathway in the control of Arabidopsis root meristem maintenance. Casamitjana-Martínez E, et al. Curr Biol, 2003 Aug 19. PMID 12932329
    5. The 14-amino acid CLV3, CLE19, and CLE40 peptides trigger consumption of the root meristem in Arabidopsis through a CLAVATA2-dependent pathway. Fiers M, et al. Plant Cell, 2005 Sep. PMID 16055633, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the proper amount of CLE19 signal is essential for the normal expression of AMS and its downstream gene networks in the regulation of anther development and pollen exine formation.
      Title: Cytological and Transcriptomic Analyses Reveal Important Roles of CLE19 in Pollen Exine Formation.
    2. CLE19 is expressed in the epidermal layers of the cotyledon primordia, hypocotyl, and root cap in the embryo. CLE19 may act as a mobile peptide co-ordinating embryo and endosperm development.
      Title: CLE19 expressed in the embryo regulates both cotyledon establishment and endosperm development in Arabidopsis.
    3. SOL1 possesses enzymatic activity to remove the C-terminal arginine residue of CLE19 proprotein in vitro, and SOL1-dependent cleavage of the C-terminal arginine residue is necessary for CLE19 activity in vivo.
      Title: SUPPRESSOR OF LLP1 1-mediated C-terminal processing is critical for CLE19 peptide activity.
    4. Data suggest that CLV3, CLE19 and CLE40 peptides represent the major active domain of the CLE proteins, which interact with an unknown cell identity-maintaining CLAVATA2 receptor complex in roots, leading to consumption of the root meristem.
      Title: The 14-amino acid CLV3, CLE19, and CLE40 peptides trigger consumption of the root meristem in Arabidopsis through a CLAVATA2-dependent pathway.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_148747.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables receptor serine/threonine kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell-cell signaling involved in cell fate commitment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of root meristem growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apoplast ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    CLAVATA3/ESR-RELATED 19
    NP_683589.1
    • CLAVATA3/ESR-RELATED 19 (CLE19); Has 6 Blast hits to 6 proteins in 3 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 6; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      8768846..8769695
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_148747.3 → NP_683589.1  CLAVATA3/ESR-RELATED 19 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_683589.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8W261
      UniProtKB/TrEMBL
      A0A178VF65, A0A5S9XF60
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8W261.1

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