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    MED6 RNA polymerase transcriptional regulation mediator-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821689, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MED6
    Official Full Name
    RNA polymerase transcriptional regulation mediator-like protein
    Primary source
    TAIR:AT3G21350
    Locus tag
    AT3G21350
    See related
    Araport:AT3G21350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
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    Genomic context

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    See MED6 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    6
    Sequence:
    Chromosome: 3; NC_003074.8 (7517070..7518777)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene Leucine-rich repeat protein kinase family protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A downy mildew effector attenuates salicylic acid-triggered immunity in Arabidopsis by interacting with the host mediator complex. Caillaud MC, et al. PLoS Biol, 2013 Dec. PMID 24339748, Free PMC Article
    2. Interaction map of Arabidopsis Mediator complex expounding its topology. Maji S, et al. Nucleic Acids Res, 2019 May 7. PMID 30793213, Free PMC Article
    3. Purification of a plant mediator from Arabidopsis thaliana identifies PFT1 as the Med25 subunit. Bäckström S, et al. Mol Cell, 2007 Jun 8. PMID 17560376
    4. CrY2H-seq: a massively multiplexed assay for deep-coverage interactome mapping. Wanamaker SA, et al. Nat Methods, 2017 Aug. PMID 28650476, Free PMC Article
    5. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001161161.1
    NM_113030.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    RNA polymerase transcriptional regulation mediator-like protein
    NP_001154633.1
    • MED6; FUNCTIONS IN: RNA polymerase II transcription mediator activity; INVOLVED IN: regulation of transcription from RNA polymerase II promoter; LOCATED IN: mediator complex; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Mediator complex, subunit Med6 (InterPro:IPR007018), Mediator complex, subunit Med6, metazoa/plant (InterPro:IPR016820); Has 341 Blast hits to 341 proteins in 163 species: Archae - 0; Bacteria - 0; Metazoa - 148; Fungi - 132; Plants - 38; Viruses - 0; Other Eukaryotes - 23 (source: NCBI BLink).
    NP_188772.2
    • MED6; FUNCTIONS IN: RNA polymerase II transcription mediator activity; INVOLVED IN: regulation of transcription from RNA polymerase II promoter; LOCATED IN: mediator complex; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Mediator complex, subunit Med6, metazoa/plant (InterPro:IPR016820), Mediator complex, subunit Med6 (InterPro:IPR007018); Has 344 Blast hits to 344 proteins in 167 species: Archae - 0; Bacteria - 0; Metazoa - 146; Fungi - 139; Plants - 37; Viruses - 0; Other Eukaryotes - 22 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      7517070..7518777
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113030.5 → NP_188772.2  RNA polymerase transcriptional regulation mediator-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188772.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VM21, A0A5S9XE82
      Conserved Domains (1) summary
      pfam04934
      Location:36 → 161
      Med6; MED6 mediator sub complex component

    2. NM_001161161.1 → NP_001154633.1  RNA polymerase transcriptional regulation mediator-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154633.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4IXJ7, Q9LIG1
      UniProtKB/TrEMBL
      A0A178VM21, A0A5S9XE82
      Conserved Domains (1) summary
      pfam04934
      Location:36 → 161
      Med6; MED6 mediator sub complex component
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4IXJ7.1

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