HSP70 heat shock protein 70 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: HSP70
Official Full Name: heat shock protein 70
Primary source: TAIR:AT3G12580
Locus tag: AT3G12580
See related: Araport:AT3G12580
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS HEAT SHOCK PROTEIN 70; ATHSP70; heat shock protein 70
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Genomic context

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See HSP70 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 2

Sequence:: Chromosome: 3; NC_003074.8 (3991117..3993886, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HSP70-4 and farnesylated AtJ3 constitute a specific HSP70/HSP40-based chaperone machinery essential for prolonged heat stress tolerance in Arabidopsis.
Title: HSP70-4 and farnesylated AtJ3 constitute a specific HSP70/HSP40-based chaperone machinery essential for prolonged heat stress tolerance in Arabidopsis.
Expansion of the evolutionarily conserved network of J-domain proteins in the Arabidopsis mitochondrial import complex.
Title: Expansion of the evolutionarily conserved network of J-domain proteins in the Arabidopsis mitochondrial import complex.
Selenium may suppress peripheral blood mononuclear cell apoptosis by modulating HSP70 and regulate levels of SIRT1 through reproductive hormone secretion and oxidant stress in women suffering fluorosis.
Title: Selenium may suppress peripheral blood mononuclear cell apoptosis by modulating HSP70 and regulate levels of SIRT1 through reproductive hormone secretion and oxidant stress in women suffering fluorosis.
ability of multiple unrelated Hsp70-binding elements to support protein import verified that the majority of TPs utilize an N-terminal Hsp70-binding domain during translocation and expand the mechanistic view of the import process
Title: Non-native, N-terminal Hsp70 molecular motor recognition elements in transit peptides support plastid protein translocation.
temperature regulated expression of AtHSP70-4 may be mediated by cell cycle transcription factors and participate in plant acclimations to non-stress temperature changes
Title: Cell cycle transcription factor E2F2 mediates non-stress temperature response of AtHSP70-4 in Arabidopsis.
This work describes a detailed quantitative interaction study between the novel plastidial chaperone receptor OEP61 and isoforms of the chaperone types Hsp70 and Hsp90 using the optical method of total internal reflection ellipsometry.
Title: Study of receptor-chaperone interactions using the optical technique of spectroscopic ellipsometry.
Chloroplasts have two chaperone systems facilitating protein translocation into the stroma: the cpHsc70 system and the Hsp93/Tic40 system.
Title: Stromal Hsp70 is important for protein translocation into pea and Arabidopsis chloroplasts.
A working hypothesis is that Hsp70 has a defense-promoting activity(s) that HopI1 or high temperature can subvert.
Title: Pseudomonas syringae hijacks plant stress chaperone machinery for virulence.
Hsc70-4 and CHIP were highly induced in ppi2 mutant plants, where they mediated the degradation of chloroplast-targeted precursors through the ubiquitin-26S proteasome system.
Title: Heat shock protein cognate 70-4 and an E3 ubiquitin ligase, CHIP, mediate plastid-destined precursor degradation through the ubiquitin-26S proteasome system in Arabidopsis.
The MAPK-EGR-1-HSP70 pathway regulates the cigarette smoke-induced inflammatory process.
Title: MAPK pathway mediates EGR-1-HSP70-dependent cigarette smoke-induced chemokine production.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_112093.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP binding	HDA more info	PubMed
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein folding	TAS Traceable Author Statement more info	PubMed
involved_in protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to heat	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to heat	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to temperature stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to virus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in cytoplasmic stress granule	IPI Inferred from Physical Interaction more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in plant-type cell wall	HDA more info	PubMed
located_in plant-type vacuole	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed

General protein information

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Preferred Names: heat shock protein 70

NP_187864.1

heat shock protein 70 (HSP70); FUNCTIONS IN: ATP binding; INVOLVED IN: in 9 processes; LOCATED IN: cytosol, mitochondrion, cell wall, plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Heat shock protein 70, conserved site (InterPro:IPR018181), Heat shock protein Hsp70 (InterPro:IPR001023), Heat shock protein 70 (InterPro:IPR013126); BEST Arabidopsis thaliana protein match is: heat shock cognate protein 70-1 (TAIR:AT5G02500.1); Has 34126 Blast hits to 33731 proteins in 4830 species: Archae - 159; Bacteria - 16481; Metazoa - 3906; Fungi - 1752; Plants - 1258; Viruses - 310; Other Eukaryotes - 10260 (source: NCBI BLink).