PDX1.1 pyridoxine biosynthesis 1.1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PDX1.1
Official Full Name: pyridoxine biosynthesis 1.1
Primary source: TAIR:AT2G38230
Locus tag: AT2G38230
See related: Araport:AT2G38230
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA PYRIDOXINE BIOSYNTHESIS 1.1; ATPDX1.1; F16M14.16; F16M14_16; pyridoxine biosynthesis 1.1
Summary: Encodes a protein predicted to function in tandem with PDX2 to form glutamine amidotransferase complex with involved in vitamin B6 biosynthesis.
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Genomic context

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See PDX1.1 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 1

Sequence:: Chromosome: 2; NC_003071.7 (16011233..16012515)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PDX proteins from Arabidopsis thaliana as novel substrates of cathepsin B: implications for vitamin B6 biosynthesis regulation.
Title: PDX proteins from Arabidopsis thaliana as novel substrates of cathepsin B: implications for vitamin B(6) biosynthesis regulation.
UVR8-dependent UV-B acclimation during the early stages of plant development may enhance normal growth under long-term exposure to solar UV.
Title: Multiple roles for UV RESISTANCE LOCUS8 in regulating gene expression and metabolite accumulation in Arabidopsis under solar ultraviolet radiation.
This study shows that the spatial and temporal expression patterns of PDX1.1 and PDX1.3, investigated at the transcript and protein level, largely overlap, but PDX1.3 is more abundant than PDX1.1. [PDX1.1]
Title: PDX1 is essential for vitamin B6 biosynthesis, development and stress tolerance in Arabidopsis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_129380.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in pyridoxal phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vitamin B6 biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	HDA more info	PubMed

General protein information

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Preferred Names: pyridoxine biosynthesis 1.1

NP_181358.1

pyridoxine biosynthesis 1.1 (PDX1.1); FUNCTIONS IN: protein heterodimerization activity; INVOLVED IN: vitamin B6 biosynthetic process, response to absence of light; LOCATED IN: cytosol, chloroplast; EXPRESSED IN: 14 plant structures; CONTAINS InterPro DOMAIN/s: Vitamin B6 biosynthesis protein (InterPro:IPR001852), Ribulose-phosphate binding barrel (InterPro:IPR011060); BEST Arabidopsis thaliana protein match is: Aldolase-type TIM barrel family protein (TAIR:AT5G01410.1); Has 4179 Blast hits to 4172 proteins in 1294 species: Archae - 234; Bacteria - 2657; Metazoa - 13; Fungi - 160; Plants - 179; Viruses - 0; Other Eukaryotes - 936 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

16011233..16012515

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_129380.3 → NP_181358.1 pyridoxine biosynthesis 1.1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_181358.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O80448

UniProtKB/TrEMBL

A0A178VZ00, A0A5S9X526, A0A7G2EII3

Conserved Domains (1) summary

PRK04180
Location:26 → 307

PRK04180; pyridoxal 5'-phosphate synthase lyase subunit PdxS